Contributions
Abstract: EP1573
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 24 Neuropsychology
Background: Recent studies show language dysfunctions in Multiple Sclerosis (MS) at the level of the lexical access to the word in naming tasks. The presence of executive dysfunctions in MS has been demonstrated and confirmed through many studies. The link between executive component and the lexical access in naming task remains to be demonstrated.
Objective: Investigate the role of executive dysfunctions on naming abilities in MS.
Method: 105 patients ran the Boston Naming test (BNT) and the BCCog (a French short cognitive battery specific to MS). They were 2 Clinically Isolated Syndrome (CIS), 1 Radiologically Isolated Syndrome (RIS), 68 Relapsing Remitting, 28 Secondary Progressive (SP), and 6 Primary Progressive (PP) forms of MS. 68 women, 37 men, with a mean age of 46 years (ET: 13.24, 19-80), a mean study level of 12 years (ET: 3.6), and a median EDSS score of 3.5 (0-8). 48 out of these patients also ran the Trail Making Test (TMT) and the Stroop test in order to evaluate respectively mental shifting and inhibitory control (2 CIS, 37 RR, 5 SP,4 PP): 36 women, 12 men, with a mean age of 43 years (ET:14.1, 19-74), a mean study level of 11 years (ET: 1.9), and a median EDSS of 3 (0-7.5).
Results: The results from the whole cohort confirm a lexical access deficit in MS on naming task. In the line of previous research the total score at the BNT is normal (mean: 53.57, SD: 6), but the patients need high number of phonological clue (mean 6, SD: 4) in order to normalize their scores. They were no significant correlation between the BNT and the BCCog scores. The lexical access deficit was stronger in the SP than in the RR forms of MS (ANOVA: f=4.4, p < 0.5). On the smaller cohort, linear regression analysis showed a significant impact of the speed processing at the TMTA (f=5, p< 0.5), the TMTB (f=13, p< 0.001), and of the mental shifting TMTB-A (f=9, p=0.005) on the lexical access. The production of phonological and semantic paraphasias was also impacted by the mental shifting (f=6, p=0.02). No naming score were linked to the inhibitory control score.
Conclusions and perspectives: The impact of executive dysfunction in MS on naming ability is enlightened through this study specifically at the level of mental shifting. It suggests the necessity to take executive dysfunction into account in order to permit an adequate reeducation of naming abilities in MS. Further studies will investigate the naming and executive functions at earlier state of the disease.
Disclosure: Joly, Cohen & Lebrun: Nothing to disclose
Abstract: EP1573
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 24 Neuropsychology
Background: Recent studies show language dysfunctions in Multiple Sclerosis (MS) at the level of the lexical access to the word in naming tasks. The presence of executive dysfunctions in MS has been demonstrated and confirmed through many studies. The link between executive component and the lexical access in naming task remains to be demonstrated.
Objective: Investigate the role of executive dysfunctions on naming abilities in MS.
Method: 105 patients ran the Boston Naming test (BNT) and the BCCog (a French short cognitive battery specific to MS). They were 2 Clinically Isolated Syndrome (CIS), 1 Radiologically Isolated Syndrome (RIS), 68 Relapsing Remitting, 28 Secondary Progressive (SP), and 6 Primary Progressive (PP) forms of MS. 68 women, 37 men, with a mean age of 46 years (ET: 13.24, 19-80), a mean study level of 12 years (ET: 3.6), and a median EDSS score of 3.5 (0-8). 48 out of these patients also ran the Trail Making Test (TMT) and the Stroop test in order to evaluate respectively mental shifting and inhibitory control (2 CIS, 37 RR, 5 SP,4 PP): 36 women, 12 men, with a mean age of 43 years (ET:14.1, 19-74), a mean study level of 11 years (ET: 1.9), and a median EDSS of 3 (0-7.5).
Results: The results from the whole cohort confirm a lexical access deficit in MS on naming task. In the line of previous research the total score at the BNT is normal (mean: 53.57, SD: 6), but the patients need high number of phonological clue (mean 6, SD: 4) in order to normalize their scores. They were no significant correlation between the BNT and the BCCog scores. The lexical access deficit was stronger in the SP than in the RR forms of MS (ANOVA: f=4.4, p < 0.5). On the smaller cohort, linear regression analysis showed a significant impact of the speed processing at the TMTA (f=5, p< 0.5), the TMTB (f=13, p< 0.001), and of the mental shifting TMTB-A (f=9, p=0.005) on the lexical access. The production of phonological and semantic paraphasias was also impacted by the mental shifting (f=6, p=0.02). No naming score were linked to the inhibitory control score.
Conclusions and perspectives: The impact of executive dysfunction in MS on naming ability is enlightened through this study specifically at the level of mental shifting. It suggests the necessity to take executive dysfunction into account in order to permit an adequate reeducation of naming abilities in MS. Further studies will investigate the naming and executive functions at earlier state of the disease.
Disclosure: Joly, Cohen & Lebrun: Nothing to disclose