Contributions
Abstract: EP1567
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 23 Neurophysiology
Background: Some studies have suggested that impaired vascular endothelial cell activation might be an early event in multiple sclerosis (MS). Hypercapnia caused by breath holding (BH) results in autoregulatory vasodilatation and an increase in CBF to the cortex. The changes of the CBF can be indirectly assessed by transcranial Doppler (TCD). In this study, we aimed to test the cerebral vascular reactivity of MS patients in response to BH using TCD.
Methods: We studied 30 patients with clinically diagnosed relapsing-remitting (RR) MS. The first TCD examination was performed in the relapse (acute exacerbation) phase of the disease and the second test was carried out at least one month later when the patient was in the remission phase. Blood flow velocities were recorded during 30 seconds of normal breathing and subsequently 15 seconds BH. Vascular reactivity was calculated as a ratio of the difference of cerebral flow velocities during BH. Normalisation of the blood flow velocities (decrease to the basal levels after breath holding) and blood flow velocity changes per second were also calculated. Since there was no significant difference between blood velocity parameters recorded on the left and right-hand side, the data were pooled. Thus, 30 patients with 60 vessels were analysed.
Results: There were non-significant values between vascular reactivity during relapse (40.5% vs. 36.9%, p=0.3) and remission periods. The time to peak velocity (12.5 sec vs. 13.4 sec, p=0.3) and the normalisation time (13.8 sec vs. 12.4 sec, p=0.15) was quite similar. Also, velocity changes per second were not different between relapse and remission periods (3.4 cm/s vs. 3.0 cm/s, p= 0.15) for the velocity rise and (5.0 cm/s vs. 4.9 cm/s, p= 0.8) for velocity decline.
Conclusion: This observation suggests that cerebrovascular reactivity is normal in patients with MS during relapse or remission period.
Disclosure:
Gulnur Tekgol Uzuner: nothing to disclose
Nevzat Uzuner: nothing to disclose
Abstract: EP1567
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 23 Neurophysiology
Background: Some studies have suggested that impaired vascular endothelial cell activation might be an early event in multiple sclerosis (MS). Hypercapnia caused by breath holding (BH) results in autoregulatory vasodilatation and an increase in CBF to the cortex. The changes of the CBF can be indirectly assessed by transcranial Doppler (TCD). In this study, we aimed to test the cerebral vascular reactivity of MS patients in response to BH using TCD.
Methods: We studied 30 patients with clinically diagnosed relapsing-remitting (RR) MS. The first TCD examination was performed in the relapse (acute exacerbation) phase of the disease and the second test was carried out at least one month later when the patient was in the remission phase. Blood flow velocities were recorded during 30 seconds of normal breathing and subsequently 15 seconds BH. Vascular reactivity was calculated as a ratio of the difference of cerebral flow velocities during BH. Normalisation of the blood flow velocities (decrease to the basal levels after breath holding) and blood flow velocity changes per second were also calculated. Since there was no significant difference between blood velocity parameters recorded on the left and right-hand side, the data were pooled. Thus, 30 patients with 60 vessels were analysed.
Results: There were non-significant values between vascular reactivity during relapse (40.5% vs. 36.9%, p=0.3) and remission periods. The time to peak velocity (12.5 sec vs. 13.4 sec, p=0.3) and the normalisation time (13.8 sec vs. 12.4 sec, p=0.15) was quite similar. Also, velocity changes per second were not different between relapse and remission periods (3.4 cm/s vs. 3.0 cm/s, p= 0.15) for the velocity rise and (5.0 cm/s vs. 4.9 cm/s, p= 0.8) for velocity decline.
Conclusion: This observation suggests that cerebrovascular reactivity is normal in patients with MS during relapse or remission period.
Disclosure:
Gulnur Tekgol Uzuner: nothing to disclose
Nevzat Uzuner: nothing to disclose