Contributions
Abstract: EP1565
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 23 Neurophysiology
Objectives: Anxiety and depressive complaints are frequently encountered in patients with multiple sclerosis (MS). Despite their prevalence, no single neurophysiological study has addressed this issue. The main purpose of this work was to assess the relationship between anxiety and depressive symptoms on one side, and cortical excitability measures on the other side.
Methods: 50 consecutive MS patients were included in the study. Anxiety and depressive symptoms were scored by the means of Hospital Anxiety and Depression Score. Cortical excitability measures consisted of the following: resting motor threshold, motor evoked potentials amplitudes and latencies, contralateral silent period, short-interval intracortical inhibition, intracortical facilitation and interhemispheric inhibition as previously described [1]. Clinical and socio-demographic data were collected. Correlation analysis was performed to assess the relationship between anxiety or depression and each of the cortical excitability measures.
Results: The cohort consisted of 26 men and 24 women. Their mean age was 51.82 ± 12.72 years. Their mean physical disability score was 5.52 ± 1.64; their mean disease duration was 11.88 ± 6.03 years. Their mean anxiety score was 5.82 ± 3.42 (range: 1-15); their mean depression score was 6.08 ± 3.66 (range: 0-14). Regarding anxiety scores, they were directly correlated with the mean (r=0.43, p=0.003) and the maximal values (r=0.35, 0.017) of interhemispheric inhibition. As for depression scores, no correlation was found with any of the neurophysiological measures. No other significant correlations were observed.
Conclusion: These results are in line with previous studies done in other populations and highlight the relationship between anxiety and callosal transfer [2]. In other words, it seems that MS patients with relatively more efficient callosal transfer tend to have higher stress level and thus higher anxiety scores than those with less efficient callosal function.
Keywords: transcranial magnetic stimulation; anxiety; depression; interhemispheric inhibition; hospital anxiety and depression scale.
References:
[1] Ayache SS, Créange A, Farhat WH, Zouari HG, Mylius V, Ahdab R, et al. Relapses in multiple sclerosis: effects of high-dose steroids on cortical excitability. Eur J Neurol. 2014; 21:630-6.
[2] Leavengood A, Weekes NY. The association between stress, hemispheric specialization, and callosal interactions. Brain Cogn. 2000; 43:306-10.
Disclosure: This research did not receive any funds. SSA declares having received travel grants or compensation from Genzyme, Biogen, Novartis and Roche. AC gave expert testimony for CSL Behring, Novartis, received grants from Biogen, Novartis, CSL Behring, GE Neuro, Octapharma, and gave lectures for Genzyme. PK, JPL, and MAC: Nothing to disclose.
Abstract: EP1565
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 23 Neurophysiology
Objectives: Anxiety and depressive complaints are frequently encountered in patients with multiple sclerosis (MS). Despite their prevalence, no single neurophysiological study has addressed this issue. The main purpose of this work was to assess the relationship between anxiety and depressive symptoms on one side, and cortical excitability measures on the other side.
Methods: 50 consecutive MS patients were included in the study. Anxiety and depressive symptoms were scored by the means of Hospital Anxiety and Depression Score. Cortical excitability measures consisted of the following: resting motor threshold, motor evoked potentials amplitudes and latencies, contralateral silent period, short-interval intracortical inhibition, intracortical facilitation and interhemispheric inhibition as previously described [1]. Clinical and socio-demographic data were collected. Correlation analysis was performed to assess the relationship between anxiety or depression and each of the cortical excitability measures.
Results: The cohort consisted of 26 men and 24 women. Their mean age was 51.82 ± 12.72 years. Their mean physical disability score was 5.52 ± 1.64; their mean disease duration was 11.88 ± 6.03 years. Their mean anxiety score was 5.82 ± 3.42 (range: 1-15); their mean depression score was 6.08 ± 3.66 (range: 0-14). Regarding anxiety scores, they were directly correlated with the mean (r=0.43, p=0.003) and the maximal values (r=0.35, 0.017) of interhemispheric inhibition. As for depression scores, no correlation was found with any of the neurophysiological measures. No other significant correlations were observed.
Conclusion: These results are in line with previous studies done in other populations and highlight the relationship between anxiety and callosal transfer [2]. In other words, it seems that MS patients with relatively more efficient callosal transfer tend to have higher stress level and thus higher anxiety scores than those with less efficient callosal function.
Keywords: transcranial magnetic stimulation; anxiety; depression; interhemispheric inhibition; hospital anxiety and depression scale.
References:
[1] Ayache SS, Créange A, Farhat WH, Zouari HG, Mylius V, Ahdab R, et al. Relapses in multiple sclerosis: effects of high-dose steroids on cortical excitability. Eur J Neurol. 2014; 21:630-6.
[2] Leavengood A, Weekes NY. The association between stress, hemispheric specialization, and callosal interactions. Brain Cogn. 2000; 43:306-10.
Disclosure: This research did not receive any funds. SSA declares having received travel grants or compensation from Genzyme, Biogen, Novartis and Roche. AC gave expert testimony for CSL Behring, Novartis, received grants from Biogen, Novartis, CSL Behring, GE Neuro, Octapharma, and gave lectures for Genzyme. PK, JPL, and MAC: Nothing to disclose.