Contributions
Abstract: EP1564
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 22 OCT
Objective: To assess the distinctive features of retinal structure in chronic relapsing inflammatory optic neuropathy (CRION) as compared to other optic neuropathies in neuromyelitis optica (NMO) and relapsing remitting multiple sclerosis (RRMS).
Background: CRION is a recurrent, steroid responsive optic neuritis without any additional neurological deficits. Diagnosis is made clinically, after recurrent attacks and exclusion of other demyelinating pathology. We used optical coherence tomography (OCT) to assess potential retinal features that may distinguish CRION from NMO and RRMS.
Design/methods: Spectral domain OCT was used to evaluate and compare the retinal layers of 35 eyes with optic neuritis in patients with CRION (8 eyes), NMO (13 eyes), RRMS (14 eyes) and 10 eyes of healthy controls (HC). The subjects were adjusted for age, disease duration and number of relapses. Peripapillary retinal nerve fiber layer (p RNFL) within superior, inferior, temporal, nasal and total macular volume (TMV) and papillomacular bundle (PMB) were measured and intra-retinal segmentation was performed to obtain retinal nerve fiber (RNFL), ganglion cell (GCL), inner plexiform (IPL), inner nuclear (INL), outer plexiform (OPL) and outer nuclear (ONL) layer thickness.
Results: pRNFL thinning was demonstrated in patients with CRION (52.46±8.3µm) as compared to HC (86.8±7.6µm, P-value=0.021) and RRMS (75.2±4.5µm, P-value=0.009) but not NMO patients (69.15±5.03µm, P-value=0.13). Within quadrants analysis, inferior quadrant was statistically thinner in CRION (69.31±11.3µm) when compared to RRMS patients (101.8±4.8, P-value=0.007). GCL thickness in macula was significantly thinner in CRION patients (0.69±0.07µm) when compared to HC (0.86±0.07µm, P-value=0.043).
Conclusion: pRNFL thickness globally and within inferior quadrant may be used as surrogates to distinguish CRION from other optic neuropathies in particular RRMS. Further longitudinal studies are warranted to confirm these findings.
Disclosure:
Maziar Eslami Farsani: Nothing to discloseSara Razmjou: Nothing to disclose
Samuel Lichtman-Mikol: Nothing to disclose
Sheridan Reed: Nothing to disclose.
Melody Gilroy: Nothing to disclose.
Carla Santiago Martinez : Nothing to disclose.
Alexandros Tselis: Nothing to disclose.
Navid Seraji-Bozorgzad: Nothing to disclose.
Evanthia Bernitsas: Research support from Novartis, Roche/Genetech, Chugai, Medimmune. Consulting fee from TEVA, Biogen, EMD Serono.
Abstract: EP1564
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 22 OCT
Objective: To assess the distinctive features of retinal structure in chronic relapsing inflammatory optic neuropathy (CRION) as compared to other optic neuropathies in neuromyelitis optica (NMO) and relapsing remitting multiple sclerosis (RRMS).
Background: CRION is a recurrent, steroid responsive optic neuritis without any additional neurological deficits. Diagnosis is made clinically, after recurrent attacks and exclusion of other demyelinating pathology. We used optical coherence tomography (OCT) to assess potential retinal features that may distinguish CRION from NMO and RRMS.
Design/methods: Spectral domain OCT was used to evaluate and compare the retinal layers of 35 eyes with optic neuritis in patients with CRION (8 eyes), NMO (13 eyes), RRMS (14 eyes) and 10 eyes of healthy controls (HC). The subjects were adjusted for age, disease duration and number of relapses. Peripapillary retinal nerve fiber layer (p RNFL) within superior, inferior, temporal, nasal and total macular volume (TMV) and papillomacular bundle (PMB) were measured and intra-retinal segmentation was performed to obtain retinal nerve fiber (RNFL), ganglion cell (GCL), inner plexiform (IPL), inner nuclear (INL), outer plexiform (OPL) and outer nuclear (ONL) layer thickness.
Results: pRNFL thinning was demonstrated in patients with CRION (52.46±8.3µm) as compared to HC (86.8±7.6µm, P-value=0.021) and RRMS (75.2±4.5µm, P-value=0.009) but not NMO patients (69.15±5.03µm, P-value=0.13). Within quadrants analysis, inferior quadrant was statistically thinner in CRION (69.31±11.3µm) when compared to RRMS patients (101.8±4.8, P-value=0.007). GCL thickness in macula was significantly thinner in CRION patients (0.69±0.07µm) when compared to HC (0.86±0.07µm, P-value=0.043).
Conclusion: pRNFL thickness globally and within inferior quadrant may be used as surrogates to distinguish CRION from other optic neuropathies in particular RRMS. Further longitudinal studies are warranted to confirm these findings.
Disclosure:
Maziar Eslami Farsani: Nothing to discloseSara Razmjou: Nothing to disclose
Samuel Lichtman-Mikol: Nothing to disclose
Sheridan Reed: Nothing to disclose.
Melody Gilroy: Nothing to disclose.
Carla Santiago Martinez : Nothing to disclose.
Alexandros Tselis: Nothing to disclose.
Navid Seraji-Bozorgzad: Nothing to disclose.
Evanthia Bernitsas: Research support from Novartis, Roche/Genetech, Chugai, Medimmune. Consulting fee from TEVA, Biogen, EMD Serono.