Contributions
Abstract: EP1563
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 22 OCT
The retina is a unique part of the CNS that contains glia and axons devoid of myelin in the retinal nerve fiber layer (RNFL), which makes them ideal for evaluation of neurodegeneration and neuroprotection.
The aim: to study the possibilities of the optical coherent tomography (OCT) method in the neurodegeneration processes monitoring in patients with MS.
Material and methods: 145 patients (285 eyes) were examined. OCT was carried out with the Cirrus 500 HD. The main group consisted of 114 patients (223 eyes) with MS according to McDonald criteria (2005, 2010). Most of the patients included in the study had relapsing-remitting course, 10.5% - secondary-progressive. For 46 patients (40% of the total), at least 2 OCT studies were obtained at an interval of about 12 months (352±152 days). Exclusion criteria: high degree of myopia, glaucoma, diabetes mellitus, other CNS diseases. The control group is 31 healthy volunteers (62 eyes).
Results: The mean macular volume in MS patients (9.8 ± 0.5 mm3), the average thickness of the macula (248 ± 26 µm) were significantly lower in comparison with the control. The average thickness of the RNFL in the main group was 85.6 ± 11 µm (in the control group - 96±8 µm), and RNFL was minimal in the temporal sector (56±12 µm). The highly sensitive and specific marker of neurodegenerative changes in the retina in MS are the temporal segments of RNFL (T, TI, TS). The thickness of the ganglion cells layer (GCL) of the retina was significantly lower in MS (72±9 µm versus 83 ± 5 µm, p< 0.05). Significant negative correlations between the dynamics of thinning of the GCL and an increase in the EDSS during the observation period were observed. The most significant correlations were revealed in the temporal and upper sectors of GCL (r = -0.44...r = -0,58, p< 0.05). These sectors can be considered promising markers of MS progression. The change in the GCL in dynamics was in the temporal segments mostly: the average thickness decreased by 0.35 µm during observation, and the thickness of the temporal and upper sectors decreased on average by 0.74 µm and 0.37 µm, respectively.
Conclusions: The dynamics of thinning of the GCL and RNFL in patients with MS correlates with an increase in neurological deficit and disease progression. Evaluation of OCT in dynamics every 12 months allows to objectify and monitor the neurodegenerative process in MS, which is necessary for predicting the course and selection of adequate therapy.
Disclosure: All authors: nothing to disclose.
Abstract: EP1563
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 22 OCT
The retina is a unique part of the CNS that contains glia and axons devoid of myelin in the retinal nerve fiber layer (RNFL), which makes them ideal for evaluation of neurodegeneration and neuroprotection.
The aim: to study the possibilities of the optical coherent tomography (OCT) method in the neurodegeneration processes monitoring in patients with MS.
Material and methods: 145 patients (285 eyes) were examined. OCT was carried out with the Cirrus 500 HD. The main group consisted of 114 patients (223 eyes) with MS according to McDonald criteria (2005, 2010). Most of the patients included in the study had relapsing-remitting course, 10.5% - secondary-progressive. For 46 patients (40% of the total), at least 2 OCT studies were obtained at an interval of about 12 months (352±152 days). Exclusion criteria: high degree of myopia, glaucoma, diabetes mellitus, other CNS diseases. The control group is 31 healthy volunteers (62 eyes).
Results: The mean macular volume in MS patients (9.8 ± 0.5 mm3), the average thickness of the macula (248 ± 26 µm) were significantly lower in comparison with the control. The average thickness of the RNFL in the main group was 85.6 ± 11 µm (in the control group - 96±8 µm), and RNFL was minimal in the temporal sector (56±12 µm). The highly sensitive and specific marker of neurodegenerative changes in the retina in MS are the temporal segments of RNFL (T, TI, TS). The thickness of the ganglion cells layer (GCL) of the retina was significantly lower in MS (72±9 µm versus 83 ± 5 µm, p< 0.05). Significant negative correlations between the dynamics of thinning of the GCL and an increase in the EDSS during the observation period were observed. The most significant correlations were revealed in the temporal and upper sectors of GCL (r = -0.44...r = -0,58, p< 0.05). These sectors can be considered promising markers of MS progression. The change in the GCL in dynamics was in the temporal segments mostly: the average thickness decreased by 0.35 µm during observation, and the thickness of the temporal and upper sectors decreased on average by 0.74 µm and 0.37 µm, respectively.
Conclusions: The dynamics of thinning of the GCL and RNFL in patients with MS correlates with an increase in neurological deficit and disease progression. Evaluation of OCT in dynamics every 12 months allows to objectify and monitor the neurodegenerative process in MS, which is necessary for predicting the course and selection of adequate therapy.
Disclosure: All authors: nothing to disclose.