Contributions
Abstract: EP1562
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 22 OCT
Goal: The aim of this study was to determined correlation between retinal nerve fiber layer (RNFL) thickness and the macula volume (MV) measured by spectral- domain OCT (SD-OCT) in familial (fMS) and sporadic (sMS) multiple sclerosis patients.
Background: . There is unresolved issue whether sMS differs from familial form of disease. Optical coherence tomography (OCT) allows quantification of retinal structures, such as RNFL thickness and MV. RNFL thickness is considered as a marker of axonal loss and MV as a marker of neuronal integrity.
Patients and method: 71 RR MS patients (31 fMS, 40 sMS) age and gender matched were included in the study. Familial MS was defined based on whether or not the probant case had a first-degree relatives with MS. Both MS groups were matched according to neurological status measured by EDSS, annual relapse rate in previous 2 years and disease duration. All patients underwent SD-OCT examination (Spectralis, Heildelberg Engineering). Total RNFL thickness and MV were assessed in right and left eyes and were expressed as a mean value for each patients.
Results: RNFL thickness in fMS was lower than in sMS but this difference was not significant (94.90±10.8 vs 97.2±8.4 p=0.4). Mean MV was lower but not significantly in fMS compared to sMS (8.2±1.0 vs 8.4±0.3 p=0.08). There was a correlation between mean RNFL thickness and MV in both forms of MS (fMS r=0.4, p=0.01and sMS r=0.5, p=0.0001) however the this correlation was stronger in sMS patients.
Disclosure:
Dr. M. Siger: nothing to disclose
Dr. M Grudziecka: nothing to disclose
Prof. K Selmaj: nothing to disclose
Abstract: EP1562
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 22 OCT
Goal: The aim of this study was to determined correlation between retinal nerve fiber layer (RNFL) thickness and the macula volume (MV) measured by spectral- domain OCT (SD-OCT) in familial (fMS) and sporadic (sMS) multiple sclerosis patients.
Background: . There is unresolved issue whether sMS differs from familial form of disease. Optical coherence tomography (OCT) allows quantification of retinal structures, such as RNFL thickness and MV. RNFL thickness is considered as a marker of axonal loss and MV as a marker of neuronal integrity.
Patients and method: 71 RR MS patients (31 fMS, 40 sMS) age and gender matched were included in the study. Familial MS was defined based on whether or not the probant case had a first-degree relatives with MS. Both MS groups were matched according to neurological status measured by EDSS, annual relapse rate in previous 2 years and disease duration. All patients underwent SD-OCT examination (Spectralis, Heildelberg Engineering). Total RNFL thickness and MV were assessed in right and left eyes and were expressed as a mean value for each patients.
Results: RNFL thickness in fMS was lower than in sMS but this difference was not significant (94.90±10.8 vs 97.2±8.4 p=0.4). Mean MV was lower but not significantly in fMS compared to sMS (8.2±1.0 vs 8.4±0.3 p=0.08). There was a correlation between mean RNFL thickness and MV in both forms of MS (fMS r=0.4, p=0.01and sMS r=0.5, p=0.0001) however the this correlation was stronger in sMS patients.
Disclosure:
Dr. M. Siger: nothing to disclose
Dr. M Grudziecka: nothing to disclose
Prof. K Selmaj: nothing to disclose