Contributions
Abstract: EP1561
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 21 Imaging
Well validated methods has been used to evaluate brain atrophy in multiple sclerosis (MS) patients, however to our knowledge these methods has not been well applied to African multiple sclerosis patients which are expected to have different profile of genetic and environmental factors that influence brain volume.
We aimed to evaluate the SIENAX method application among North African patients with MS. Three groups were recruited; a group of relapsing onset Egyptian MS patients (n=47), a group of Egyptian healthy controls (n=30), and a third group of healthy controls from the publicly available OASIS MRI database (n=181) for comparing the possible influence of racial and environmental factors. The three groups were matched for both age and sex.
We used a 1.5T Philips scanner for acquisition of a 3D T1 volume of the brain, and a FLAIR sequence for lesion load. Analysis included Lesion Load (LL) estimation (MIPAV software), Normalized Brain Volume (NBV) (SIENAX method) after performing adequate lesion masking in the MS patient group, subcortical segmentation (FIRST part of FSL software).
For MS patient group mean disease duration was 5.8 (4.96) years (SD), only 10 patients were under any of the disease modifying treatments. Total intracranial volume was highly significantly lower at the Egyptian Population (1245.07 (SD 115.72)) ml (patients and controls) compared to OASIS database (1480.50 (SD 158.30)) ml (p< 0.001). Normalized brain volume was also highly significantly lower between Egyptian healthy controls (76.7% of intracranial volume SD 0.05%) and OASIS database (84.1% of intracranial volume SD 0.02%) (p< 0.00.1).
NBV was significantly lower among MS Patients 1427.35 (SD 97.45) ml compared to Egyptian healthy controls 1494.2 (SD 72.21) ml (p=0.008). Thalamic fraction was significantly lower (calculated as the volume of both thalami divided by intracranial volume) in patients compared to controls (p=0.001), hippocampi (P< 0.002 and P< 0.01 right and left), but were not different in normalized cortical volumes or cord cross-sectional area.
Racial and environmental factors appears to clearly influence brain volume in health and disease conditions. SIENAX and FIRT methods for evaluation of global as well as regional brain atrophy were able to demonstrate differences between healthy controls and north African MS patients. Careful consideration of generalizing the brain atrophy measurements across different geographical, environmental as well as racial factors.
Disclosure:
Professor Fathi Afifi has nothing to disclose
Dr Mohammad Aboulwafa has nothing to disclose
Abstract: EP1561
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 21 Imaging
Well validated methods has been used to evaluate brain atrophy in multiple sclerosis (MS) patients, however to our knowledge these methods has not been well applied to African multiple sclerosis patients which are expected to have different profile of genetic and environmental factors that influence brain volume.
We aimed to evaluate the SIENAX method application among North African patients with MS. Three groups were recruited; a group of relapsing onset Egyptian MS patients (n=47), a group of Egyptian healthy controls (n=30), and a third group of healthy controls from the publicly available OASIS MRI database (n=181) for comparing the possible influence of racial and environmental factors. The three groups were matched for both age and sex.
We used a 1.5T Philips scanner for acquisition of a 3D T1 volume of the brain, and a FLAIR sequence for lesion load. Analysis included Lesion Load (LL) estimation (MIPAV software), Normalized Brain Volume (NBV) (SIENAX method) after performing adequate lesion masking in the MS patient group, subcortical segmentation (FIRST part of FSL software).
For MS patient group mean disease duration was 5.8 (4.96) years (SD), only 10 patients were under any of the disease modifying treatments. Total intracranial volume was highly significantly lower at the Egyptian Population (1245.07 (SD 115.72)) ml (patients and controls) compared to OASIS database (1480.50 (SD 158.30)) ml (p< 0.001). Normalized brain volume was also highly significantly lower between Egyptian healthy controls (76.7% of intracranial volume SD 0.05%) and OASIS database (84.1% of intracranial volume SD 0.02%) (p< 0.00.1).
NBV was significantly lower among MS Patients 1427.35 (SD 97.45) ml compared to Egyptian healthy controls 1494.2 (SD 72.21) ml (p=0.008). Thalamic fraction was significantly lower (calculated as the volume of both thalami divided by intracranial volume) in patients compared to controls (p=0.001), hippocampi (P< 0.002 and P< 0.01 right and left), but were not different in normalized cortical volumes or cord cross-sectional area.
Racial and environmental factors appears to clearly influence brain volume in health and disease conditions. SIENAX and FIRT methods for evaluation of global as well as regional brain atrophy were able to demonstrate differences between healthy controls and north African MS patients. Careful consideration of generalizing the brain atrophy measurements across different geographical, environmental as well as racial factors.
Disclosure:
Professor Fathi Afifi has nothing to disclose
Dr Mohammad Aboulwafa has nothing to disclose