Contributions
Abstract: EP1558
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 21 Imaging
Multiple sclerosis (MS) shows variable disease characteristics at different ethnicities and geographical regions. Magnetic resonance imaging (MRI) features of MS are not adequately described in African Mediterranean region. We aimed to describe main clinical and MRI features of MS in Egyptian patients.
Relapsing onset MS patients (n=47) and a group of age and sex matched healthy controls (n=20) were recruited. All subjects had a standardized clinical evaluation, and an MRI examination (1.5 Tesla scanner, FLAIR and T2 for lesion load (LL) estimation and a sagittal 3D-T1 for volumetric assessment). Analysis included LL estimation (MIPAV software), whole brain atrophy (SIENAX method), subcortical segmentation (FIRST part of FSL software) and mean upper cord cross-sectional area CSA. Correlation between clinical and MRI parameters were done using partial correlation.
Mean disease duration was 5.8 (4.96) years (SD), only 10 patients were under any of the disease modifying treatments. Normalized Whole brain volume (NWBV) was significantly lower in MS group compared to controls (p=0.008), and the thalamic fraction (volume of both thalami divided by total intracranial volume) (p=0.001), right and left hippocampi (P=0.006 and 0.06 respectively), but not with the normalized grey matter volume or the cord cross-sectional area (CSA).
EDSS correlated well with lesion load (p=0.005, r=0.44), NWBV (p=0.01, r=0.48), normalized cortical volume (p=0.001, r=0.58), thalamic fraction (p=0.03, r=0.36), caudate fraction (p=0.001, r=0.43) and cord CSA (p=0.03, r=0.43).
MRI features of MS in North African population appear to be replicating what has been known from other MS studies elsewhere. However smaller intracranial volume and cord CSA even in healthy controls compared to available data from western and European countries. We postulate that these smaller values represent a smaller tissue reserve that might interpret the relatively better correlation between lesion load and clinically disability compared to other studies, and might also explain the relatively more aggressive nature of the disease in Africa.
Disclosure:
Dr Mohammad Hamed has Nothing to disclose
prof. Mohammad AlBahay has nothing to disclose
Prof. Hussien Mohammad has nothing to disclose
Dr Abdalla Metwally has nothing to disclose
Dr Mohammad Aboulwafa has nothing to disclose
Dr Mohammad Atallah has nothing to disclose
Abstract: EP1558
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 21 Imaging
Multiple sclerosis (MS) shows variable disease characteristics at different ethnicities and geographical regions. Magnetic resonance imaging (MRI) features of MS are not adequately described in African Mediterranean region. We aimed to describe main clinical and MRI features of MS in Egyptian patients.
Relapsing onset MS patients (n=47) and a group of age and sex matched healthy controls (n=20) were recruited. All subjects had a standardized clinical evaluation, and an MRI examination (1.5 Tesla scanner, FLAIR and T2 for lesion load (LL) estimation and a sagittal 3D-T1 for volumetric assessment). Analysis included LL estimation (MIPAV software), whole brain atrophy (SIENAX method), subcortical segmentation (FIRST part of FSL software) and mean upper cord cross-sectional area CSA. Correlation between clinical and MRI parameters were done using partial correlation.
Mean disease duration was 5.8 (4.96) years (SD), only 10 patients were under any of the disease modifying treatments. Normalized Whole brain volume (NWBV) was significantly lower in MS group compared to controls (p=0.008), and the thalamic fraction (volume of both thalami divided by total intracranial volume) (p=0.001), right and left hippocampi (P=0.006 and 0.06 respectively), but not with the normalized grey matter volume or the cord cross-sectional area (CSA).
EDSS correlated well with lesion load (p=0.005, r=0.44), NWBV (p=0.01, r=0.48), normalized cortical volume (p=0.001, r=0.58), thalamic fraction (p=0.03, r=0.36), caudate fraction (p=0.001, r=0.43) and cord CSA (p=0.03, r=0.43).
MRI features of MS in North African population appear to be replicating what has been known from other MS studies elsewhere. However smaller intracranial volume and cord CSA even in healthy controls compared to available data from western and European countries. We postulate that these smaller values represent a smaller tissue reserve that might interpret the relatively better correlation between lesion load and clinically disability compared to other studies, and might also explain the relatively more aggressive nature of the disease in Africa.
Disclosure:
Dr Mohammad Hamed has Nothing to disclose
prof. Mohammad AlBahay has nothing to disclose
Prof. Hussien Mohammad has nothing to disclose
Dr Abdalla Metwally has nothing to disclose
Dr Mohammad Aboulwafa has nothing to disclose
Dr Mohammad Atallah has nothing to disclose