Contributions
Abstract: EP1555
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 21 Imaging
OFSEP (Observatoire Français de la Sclérose en Plaques) is a national cohort of patients with MS and related disorders, set up in 2010 from a rich historical background use of EDMUS in France. It aims at collecting standardized, high-quality, longitudinal data, including clinical, biological and imaging follow-up of patients with MS and makes it available to the research and industrial community and health authorities. In December 2016, more than 54.000 clinical files were available, progressively enriched with biological and imaging data. Over the past two decades, the clinical use of MRI in patients with MS has considerably impacted the diagnostic procedure as well as prognostic indicators, including evaluation of the treatment-response up to the concept of “No Evidence of Disease Activity”. Therefore, standardized MRI examinations only can allow a reliable comparison of successive MRIs over time that will guide therapeutic decision. The OFSEP imaging group designed a consensus standardized MRI protocol that could fulfil the needs of clinician in their decision-making process but also be available for research purpose. The group worked closely with main MRI companies to promote the MRI “OFSEP protocol” in an “exam card” available on all new system (see ofesp.org). MRI data are transferred and stored onto a centralized national facility, Shanoir, with respect to privacy protection in agreement with French national authority (CNIL). All the data are pseudonimized locally on the hospital computer priory to the transfer; this step allows inter-operability with biological and clinical databases for research. We are currently in the process of spreading the MRI protocol across French MRI centres. 18 centers started to export MRI data mainly through PACS connection to load their data retrospectively. All the data collected will be then available to the research community as well as the biological and clinical databases.
Acknowledgments: The authors would like to thank all the patients included, la fondation ARSEP, the ANR, the UCBL, the HCL and all the OFSEP's investigators.
Disclosure:
Jean-Christophe Brisset: nothing to disclose.
Vincent Dousset: nothing to disclose.
Francois Cotton : nothing to disclose.
Sandra Vukusic has received consultancy fees, speaker fees, research grants (non-personal) or honoraria from Biogen, Geneuro, Genzyme-Sanofi, Medday, Merck-Serono, Novartis, Roche and Teva
Abstract: EP1555
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 21 Imaging
OFSEP (Observatoire Français de la Sclérose en Plaques) is a national cohort of patients with MS and related disorders, set up in 2010 from a rich historical background use of EDMUS in France. It aims at collecting standardized, high-quality, longitudinal data, including clinical, biological and imaging follow-up of patients with MS and makes it available to the research and industrial community and health authorities. In December 2016, more than 54.000 clinical files were available, progressively enriched with biological and imaging data. Over the past two decades, the clinical use of MRI in patients with MS has considerably impacted the diagnostic procedure as well as prognostic indicators, including evaluation of the treatment-response up to the concept of “No Evidence of Disease Activity”. Therefore, standardized MRI examinations only can allow a reliable comparison of successive MRIs over time that will guide therapeutic decision. The OFSEP imaging group designed a consensus standardized MRI protocol that could fulfil the needs of clinician in their decision-making process but also be available for research purpose. The group worked closely with main MRI companies to promote the MRI “OFSEP protocol” in an “exam card” available on all new system (see ofesp.org). MRI data are transferred and stored onto a centralized national facility, Shanoir, with respect to privacy protection in agreement with French national authority (CNIL). All the data are pseudonimized locally on the hospital computer priory to the transfer; this step allows inter-operability with biological and clinical databases for research. We are currently in the process of spreading the MRI protocol across French MRI centres. 18 centers started to export MRI data mainly through PACS connection to load their data retrospectively. All the data collected will be then available to the research community as well as the biological and clinical databases.
Acknowledgments: The authors would like to thank all the patients included, la fondation ARSEP, the ANR, the UCBL, the HCL and all the OFSEP's investigators.
Disclosure:
Jean-Christophe Brisset: nothing to disclose.
Vincent Dousset: nothing to disclose.
Francois Cotton : nothing to disclose.
Sandra Vukusic has received consultancy fees, speaker fees, research grants (non-personal) or honoraria from Biogen, Geneuro, Genzyme-Sanofi, Medday, Merck-Serono, Novartis, Roche and Teva