Contributions
Abstract: EP1547
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 21 Imaging
OBJETIVE: To describe the radiological characteristics of the NMO and to evaluate differences between the AQP4 positive and negative groups.
Methods: Patients with NMO (2006) followed between 1999 and 2015 at Hospital da Lagoa (RJ) who dosed anti-AQP4 by IFF and / or cellular methods, with at least two available skull and spinal MRI scans were selected for this study . The NMO complex syndromes (NMO-CS) criteria of 2015 were applied to these patients. The MRI analysis was performed by two specialists who investigated the typical radiological signs for NMO-CS. The frequency and characteristic of the lesions were compared in the serum positive and negative AQP4 groups.
Results: The 38 patients with NMO included in the study fulfilled the diagnostic criteria of NMO-CS (2015). The radiological criterion was filled with the initial MRI in 60% of the cases considering specific supratentorial, infratentorial lesions, in the optic nerve and medulla lesions. The most frequent lesions in the AQP4 positive patients in the order of frequency were: 1st - Cervical myelitis, 2nd - Bilateral or unilateral optic neuritis and 3rd - Brainstem lesions. In the negative AQP4 the order was: 1st - Dorsal myelitis, 2nd - Unilateral optic neuritis and 3rd - Brainstem lesions.
Conclusion: (1) The features found in the NMO were: extensive lesion of the optic nerve until the chiasm, Peri-chiasmatic regions and extensive atrophy of the optic nerve; Extensive longitudinal uni or bilateral lesion of the spinal cortical tract from the origin to the brainstem; Cervical myelitis with extension to the bulb and extensive atrophy of the spinal cord; Large coalescing lesions on the trunk and brainstem with ependymal lesions; Extensive lesions in the cerebral hemispheres in continuity with supratentorial ependymal lesions. (2) There was no significant difference in the brain lesions according to AQP4 status.
Key words: Optic neuromyelitis, Multiple sclerosis. Magnetic Resonance Imaging
Disclosure: There is no conflict of interest.
Abstract: EP1547
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 21 Imaging
OBJETIVE: To describe the radiological characteristics of the NMO and to evaluate differences between the AQP4 positive and negative groups.
Methods: Patients with NMO (2006) followed between 1999 and 2015 at Hospital da Lagoa (RJ) who dosed anti-AQP4 by IFF and / or cellular methods, with at least two available skull and spinal MRI scans were selected for this study . The NMO complex syndromes (NMO-CS) criteria of 2015 were applied to these patients. The MRI analysis was performed by two specialists who investigated the typical radiological signs for NMO-CS. The frequency and characteristic of the lesions were compared in the serum positive and negative AQP4 groups.
Results: The 38 patients with NMO included in the study fulfilled the diagnostic criteria of NMO-CS (2015). The radiological criterion was filled with the initial MRI in 60% of the cases considering specific supratentorial, infratentorial lesions, in the optic nerve and medulla lesions. The most frequent lesions in the AQP4 positive patients in the order of frequency were: 1st - Cervical myelitis, 2nd - Bilateral or unilateral optic neuritis and 3rd - Brainstem lesions. In the negative AQP4 the order was: 1st - Dorsal myelitis, 2nd - Unilateral optic neuritis and 3rd - Brainstem lesions.
Conclusion: (1) The features found in the NMO were: extensive lesion of the optic nerve until the chiasm, Peri-chiasmatic regions and extensive atrophy of the optic nerve; Extensive longitudinal uni or bilateral lesion of the spinal cortical tract from the origin to the brainstem; Cervical myelitis with extension to the bulb and extensive atrophy of the spinal cord; Large coalescing lesions on the trunk and brainstem with ependymal lesions; Extensive lesions in the cerebral hemispheres in continuity with supratentorial ependymal lesions. (2) There was no significant difference in the brain lesions according to AQP4 status.
Key words: Optic neuromyelitis, Multiple sclerosis. Magnetic Resonance Imaging
Disclosure: There is no conflict of interest.