Contributions
Abstract: EP1534
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 21 Imaging
Introduction: Optical coherence tomography studies have previously demonstrated structural retinal changes in patients with Multiple Sclerosis (MS). Retinal oximetry is a non-invasive measurement of retinal metabolism and studies have shown changes in retinal oxygen saturation in another central nervous system disease.
Objective: To compare oxygen saturation in retinal blood vessels in MS patients with or without optic neuritis (ON) and healthy controls.
Method: Oxygen saturation of hemoglobin was measured in retinal blood vessels, with spectrophotometric noninvasive retinal oximeter. 29 MS patients, 12 with and 17 without history of ON were compared to 24 healthy individuals in a case-control study.
Results: Retinal arteriolar oxygen saturation was significantly higher in MS patients compared to healthy controls (96.6 ± 3.2% vs. 94.1 ± 4.0%; p=0.02, mean±SD). There was an increased retinal arteriolar oxygen saturation in MS patients without ON compared to healthy controls (96.6 ± 2.7% vs. 94.1 ± 4.0%; p=0.03 mean±SD) and a trend towards an increase in MS patients with ON compared to healthy controls (p=0.08). Retinal oxygen saturation in retinal venules was not significantly increased in MS patients compared to healthy controls (60.2 ± 5.4% vs. 57.9 ± 5.8; p=0.15, mean±SD). There were no significant changes in retinal venule saturation between MS patients with ON (p=0.12) or MS patients without ON (p=0.37) compared to healthy controls. Retinal arteriovenous difference was not significantly changed in MS patients compared to healthy controls (36.4 ± 5.5% vs. 36.2 ± 4.4%; p=0.87). There was no significant difference measured in retinal vessel saturation when MS patients with ON and without ON were compared.
Conclusion: These results show metabolic changes in MS patients compared to healthy cohort. If confirmed in prospective studies, non-invasive retinal oxygen imaging may be a promising biomarker for MS.
Disclosure:
Helle Hvilsted Nielsen: Helle H Nielsen has served on scientific advisory boards, received support for congress participation, received speaker honoraria, and received research support from Biogen, Merck-Serono, UCB Nordic, Lundbeck, and Novartis.
Anna Einarsdottir: nothing to disclose
Jakob Grauslund: nothing to disclose
Thomas Lee Torp: nothing to disclose
Abstract: EP1534
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 21 Imaging
Introduction: Optical coherence tomography studies have previously demonstrated structural retinal changes in patients with Multiple Sclerosis (MS). Retinal oximetry is a non-invasive measurement of retinal metabolism and studies have shown changes in retinal oxygen saturation in another central nervous system disease.
Objective: To compare oxygen saturation in retinal blood vessels in MS patients with or without optic neuritis (ON) and healthy controls.
Method: Oxygen saturation of hemoglobin was measured in retinal blood vessels, with spectrophotometric noninvasive retinal oximeter. 29 MS patients, 12 with and 17 without history of ON were compared to 24 healthy individuals in a case-control study.
Results: Retinal arteriolar oxygen saturation was significantly higher in MS patients compared to healthy controls (96.6 ± 3.2% vs. 94.1 ± 4.0%; p=0.02, mean±SD). There was an increased retinal arteriolar oxygen saturation in MS patients without ON compared to healthy controls (96.6 ± 2.7% vs. 94.1 ± 4.0%; p=0.03 mean±SD) and a trend towards an increase in MS patients with ON compared to healthy controls (p=0.08). Retinal oxygen saturation in retinal venules was not significantly increased in MS patients compared to healthy controls (60.2 ± 5.4% vs. 57.9 ± 5.8; p=0.15, mean±SD). There were no significant changes in retinal venule saturation between MS patients with ON (p=0.12) or MS patients without ON (p=0.37) compared to healthy controls. Retinal arteriovenous difference was not significantly changed in MS patients compared to healthy controls (36.4 ± 5.5% vs. 36.2 ± 4.4%; p=0.87). There was no significant difference measured in retinal vessel saturation when MS patients with ON and without ON were compared.
Conclusion: These results show metabolic changes in MS patients compared to healthy cohort. If confirmed in prospective studies, non-invasive retinal oxygen imaging may be a promising biomarker for MS.
Disclosure:
Helle Hvilsted Nielsen: Helle H Nielsen has served on scientific advisory boards, received support for congress participation, received speaker honoraria, and received research support from Biogen, Merck-Serono, UCB Nordic, Lundbeck, and Novartis.
Anna Einarsdottir: nothing to disclose
Jakob Grauslund: nothing to disclose
Thomas Lee Torp: nothing to disclose