Contributions
Abstract: EP1527
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 21 Imaging
Background: Arterial and secondary neck vessel system characteristics of multiple sclerosis (MS) patients were not previously investigated.
Objectives: To examine the frequency of neck vessels and their cross-sectional areas (CSA, in mm2) between MS patients and healthy controls (HCs).
Methods and materials: In this study, 193 MS patients and 193 age- and sex-matched HCs underwent two-dimensional (2D) time-of-flight (TOF) angiography at 3T. The main arterial (carotid and vertebral), venous (internal jugular), and secondary neck vessels were examined at 4 separate cervical levels (C2/3, C4, C5/6 and C7/T1). The analysis of covariance (ANCOVA) adjusted for age, body-mass-index, smoking status, hypertension, and heart disease was used to compare the differences between MS patients and HCs.
Results: After controlling for all confounding factors, MS patients had significantly lower CSA of the carotid arteries at C2/3 (p=0.03), C5/6 (p=0.026) and C7/T1 (p=0.005) levels, as well as of vertebral arteries at C2/3 (p=0.02), C4 (p=0.012) and C7/T1 (p=0.006) levels, compared to HCs. Higher frequency of secondary neck vessels was found at all 4 levels in MS patients: C2/3 (12.9 vs. 10, p< 0.001), C4 (9.1 vs. 7.5, p< 0.001), C5/6 (7.8 vs. 6.8, p=0.012) and C7/T1 (8.8 vs. 6, p< 0.001). The total CSA of secondary neck vessels was also significantly lower at all 4 levels (p< 0.03). In a subgroup of subjects without cardiovascular risk factors (>70% of the study sample), similar differences were found for arterial and secondary neck vessels between MS patients and HCs. No significant differences in the CSA of jugular veins was found between MS and HCs.
Conclusion: MS patients showed lower CSA of carotid and vertebral arteries and higher frequency of secondary neck vessels and their CSAs compared to HCs, independently of the presence of cardiovascular risk factors.
Disclosure:
Disclosures of conflict of interest: None.
Author disclosures:
Pavel Belov, Dejan Jakimovski, Jacqueline Krawiecki, Jesper Hagemeierm and Christopher Magnano have nothing to disclose.
Bianca Weinstock-Guttman received honoraria as a speaker and as a consultant for Biogen Idec, Teva Pharmaceuticals, EMD Serono, Genzyme&Sanofi, Novartis and Acorda. Dr Weinstock-Guttman received research funds from Biogen Idec, Teva Pharmaceuticals, EMD Serono, Genzyme&Sanofi, Novartis, Acorda.
Robert Zivadinov received personal compensation from Teva Pharmaceuticals, Biogen Idec, EMD Serono, Genzyme-Sanofi, Claret Medical, IMS Health and Novartis for speaking and consultant fees. He received financial support for research activities from Teva Pharmaceuticals, Genzyme-Sanofi, Novartis, Claret Medical, Intekrin-Coherus and IMS Health.
Abstract: EP1527
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 21 Imaging
Background: Arterial and secondary neck vessel system characteristics of multiple sclerosis (MS) patients were not previously investigated.
Objectives: To examine the frequency of neck vessels and their cross-sectional areas (CSA, in mm2) between MS patients and healthy controls (HCs).
Methods and materials: In this study, 193 MS patients and 193 age- and sex-matched HCs underwent two-dimensional (2D) time-of-flight (TOF) angiography at 3T. The main arterial (carotid and vertebral), venous (internal jugular), and secondary neck vessels were examined at 4 separate cervical levels (C2/3, C4, C5/6 and C7/T1). The analysis of covariance (ANCOVA) adjusted for age, body-mass-index, smoking status, hypertension, and heart disease was used to compare the differences between MS patients and HCs.
Results: After controlling for all confounding factors, MS patients had significantly lower CSA of the carotid arteries at C2/3 (p=0.03), C5/6 (p=0.026) and C7/T1 (p=0.005) levels, as well as of vertebral arteries at C2/3 (p=0.02), C4 (p=0.012) and C7/T1 (p=0.006) levels, compared to HCs. Higher frequency of secondary neck vessels was found at all 4 levels in MS patients: C2/3 (12.9 vs. 10, p< 0.001), C4 (9.1 vs. 7.5, p< 0.001), C5/6 (7.8 vs. 6.8, p=0.012) and C7/T1 (8.8 vs. 6, p< 0.001). The total CSA of secondary neck vessels was also significantly lower at all 4 levels (p< 0.03). In a subgroup of subjects without cardiovascular risk factors (>70% of the study sample), similar differences were found for arterial and secondary neck vessels between MS patients and HCs. No significant differences in the CSA of jugular veins was found between MS and HCs.
Conclusion: MS patients showed lower CSA of carotid and vertebral arteries and higher frequency of secondary neck vessels and their CSAs compared to HCs, independently of the presence of cardiovascular risk factors.
Disclosure:
Disclosures of conflict of interest: None.
Author disclosures:
Pavel Belov, Dejan Jakimovski, Jacqueline Krawiecki, Jesper Hagemeierm and Christopher Magnano have nothing to disclose.
Bianca Weinstock-Guttman received honoraria as a speaker and as a consultant for Biogen Idec, Teva Pharmaceuticals, EMD Serono, Genzyme&Sanofi, Novartis and Acorda. Dr Weinstock-Guttman received research funds from Biogen Idec, Teva Pharmaceuticals, EMD Serono, Genzyme&Sanofi, Novartis, Acorda.
Robert Zivadinov received personal compensation from Teva Pharmaceuticals, Biogen Idec, EMD Serono, Genzyme-Sanofi, Claret Medical, IMS Health and Novartis for speaking and consultant fees. He received financial support for research activities from Teva Pharmaceuticals, Genzyme-Sanofi, Novartis, Claret Medical, Intekrin-Coherus and IMS Health.