Contributions
Abstract: EP1523
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 21 Imaging
Background: Grey matter (GM) damage is a well-known phenomenon in the early stages of multiple sclerosis (MS), but its specific spatial distribution, clinical and cerebrospinal fluid (CSF) correlates are not well known.
Objective: To evaluate the regional distribution of cortical and subcortical GM damage in patients with clinically isolated syndromes (CIS) and to investigate whether clinical, CSF and radiological features are associated with specific damage in certain GM regions, both at baseline and during the first year of follow-up.
Materials and methods: From an ongoing longitudinal CIS cohort 121 patients with 3T magnetic resonance imaging (MRI) scans performed at baseline (3 months) and follow-up (12 months) were included. The selected cohort was classified according to their clinical, CSF and radiological correlates as follows: (1) clinical topography as optic neuritis (ON)(n=53) or OTHER (n=68); (2) presence or absence of oligoclonal bands (OCB) (n=107) as OCB+ (n=56) or OCB- (n=51); (3) number of Barkhof criteria fulfilled at baseline MRI as 3-4 criteria fulfilled, named Barkhof High (BH) (n=37) or 0-1-2 criteria fulfilled, named Barkhof Low (BL) (n=84). The scans were analyzed using the longitudinal stream included in the FreeSurfer software package. Baseline values and yearly change rates for lobar cortical thickness as well as for volumes of relevant subcortical structures were compared between subgroups adjusting for age and gender; results were corrected for multiple comparisons.
Results: At baseline significant cortical thinning was observed in patients with BH compared to BL in the parietal and occipital lobes bilaterally, in the left lateral and medial temporal lobe, and in the left cingulum, whereas no significant differences were observed between the other subgroups. At baseline, OCB+ patients showed lower volumes in bilateral thalami compared to OCB-, and BH patients showed lower volumes in the left putamen and bilaterally in thalami and brainstem compared to BL patients; no differences were observed between ON and
Conclusions: The spatial distribution of cortical and subcortical damage is influenced by the clinical, CSF and radiological characteristics of CIS patients.
Disclosure: Nothing to disclose for the present work
Abstract: EP1523
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 21 Imaging
Background: Grey matter (GM) damage is a well-known phenomenon in the early stages of multiple sclerosis (MS), but its specific spatial distribution, clinical and cerebrospinal fluid (CSF) correlates are not well known.
Objective: To evaluate the regional distribution of cortical and subcortical GM damage in patients with clinically isolated syndromes (CIS) and to investigate whether clinical, CSF and radiological features are associated with specific damage in certain GM regions, both at baseline and during the first year of follow-up.
Materials and methods: From an ongoing longitudinal CIS cohort 121 patients with 3T magnetic resonance imaging (MRI) scans performed at baseline (3 months) and follow-up (12 months) were included. The selected cohort was classified according to their clinical, CSF and radiological correlates as follows: (1) clinical topography as optic neuritis (ON)(n=53) or OTHER (n=68); (2) presence or absence of oligoclonal bands (OCB) (n=107) as OCB+ (n=56) or OCB- (n=51); (3) number of Barkhof criteria fulfilled at baseline MRI as 3-4 criteria fulfilled, named Barkhof High (BH) (n=37) or 0-1-2 criteria fulfilled, named Barkhof Low (BL) (n=84). The scans were analyzed using the longitudinal stream included in the FreeSurfer software package. Baseline values and yearly change rates for lobar cortical thickness as well as for volumes of relevant subcortical structures were compared between subgroups adjusting for age and gender; results were corrected for multiple comparisons.
Results: At baseline significant cortical thinning was observed in patients with BH compared to BL in the parietal and occipital lobes bilaterally, in the left lateral and medial temporal lobe, and in the left cingulum, whereas no significant differences were observed between the other subgroups. At baseline, OCB+ patients showed lower volumes in bilateral thalami compared to OCB-, and BH patients showed lower volumes in the left putamen and bilaterally in thalami and brainstem compared to BL patients; no differences were observed between ON and
Conclusions: The spatial distribution of cortical and subcortical damage is influenced by the clinical, CSF and radiological characteristics of CIS patients.
Disclosure: Nothing to disclose for the present work