Contributions
Abstract: EP1511
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 19 Neurodegeneration
Objective: In multiple sclerosis (MS), deep grey matter (DGM) atrophy has been recognised as a crucial component of the disease, presenting early and being associated with disability. Although the precise mechanism underlying grey matter atrophy is unknown, several hypotheses have been postulated. As our previous study found that hypothalamic alterations correlate with clinical outcomes, we decided to further test the hypothesis that hypothalamic metabolism is related to DGM atrophy.
Methods: We used 1H - Magnetic Resonance spectroscopy (1HMRS) of hypothalamus via 1.5T to test its metabolites in 26 patients with RRMS and 22 healthy age-matched controls. DGM atrophy was evaluated via the third ventricular widths (3VW) in T1 weighted MRI pictures. Metabolites of N-acetyl aspartate (NAA), Choline (Cho), Glutamate and Glutamine (Glx), myo-Inositol (mIns) and Creatine (Cr) and their ratios were correlated with Multiple Sclerosis Severity Scale (MSSS) and 3VW.
Results: In linear regression, for each log unit increase in 3VW, a 0.35 increase in MSSS was identified (P = 0.0039); whereas for each log unit increase in Glx/NAA, a 0.93 increase in MSSS was identified
(P = 0.090).
Conclusions: In our study, we found that both NAA and Glx are associated with neurodegeneration of DGM, but Glx was found to be superior in determining both atrophy of DGM and disease burden.
This work is supported by Project APVV-15-0107, and VEGA 1/0287/16
Disclosure:
Ema Kantorova, Hubert Poláček, Petra Hnilicová, Eva Baranovičová, Marián Grendár, Kamil Zeleňák, Štefan Sivák, Vladimír Nosáľ, Dušan Dobrota, and Egon Kurča have nothing to dislose.
Abstract: EP1511
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 19 Neurodegeneration
Objective: In multiple sclerosis (MS), deep grey matter (DGM) atrophy has been recognised as a crucial component of the disease, presenting early and being associated with disability. Although the precise mechanism underlying grey matter atrophy is unknown, several hypotheses have been postulated. As our previous study found that hypothalamic alterations correlate with clinical outcomes, we decided to further test the hypothesis that hypothalamic metabolism is related to DGM atrophy.
Methods: We used 1H - Magnetic Resonance spectroscopy (1HMRS) of hypothalamus via 1.5T to test its metabolites in 26 patients with RRMS and 22 healthy age-matched controls. DGM atrophy was evaluated via the third ventricular widths (3VW) in T1 weighted MRI pictures. Metabolites of N-acetyl aspartate (NAA), Choline (Cho), Glutamate and Glutamine (Glx), myo-Inositol (mIns) and Creatine (Cr) and their ratios were correlated with Multiple Sclerosis Severity Scale (MSSS) and 3VW.
Results: In linear regression, for each log unit increase in 3VW, a 0.35 increase in MSSS was identified (P = 0.0039); whereas for each log unit increase in Glx/NAA, a 0.93 increase in MSSS was identified
(P = 0.090).
Conclusions: In our study, we found that both NAA and Glx are associated with neurodegeneration of DGM, but Glx was found to be superior in determining both atrophy of DGM and disease burden.
This work is supported by Project APVV-15-0107, and VEGA 1/0287/16
Disclosure:
Ema Kantorova, Hubert Poláček, Petra Hnilicová, Eva Baranovičová, Marián Grendár, Kamil Zeleňák, Štefan Sivák, Vladimír Nosáľ, Dušan Dobrota, and Egon Kurča have nothing to dislose.