Contributions
Abstract: EP1510
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 19 Neurodegeneration
There are few studies regarding brain volume loss in Neuromyelitis optica spectrum disorder (NMOSD) with contradictory results. Our aim was to describe longitudinaly brain volume in a cohort of NMOSD patients compared to multiple sclerosis (MS) patients
Methods: Patients with diagnosis of NMOSD who had at least two MRI with a two year interval were included. MS patients matched by age and sex were included. SIENA and SIENAXr were used to measure brain volume.
Results: 20 NMOSD patients were included, 15 women (75%). Median age 39±12. The first symptom was longitudinally extensive transverse myelitis (LETM) in 9 (45%), optic neuritis (ON) in 7 (35%), LETM plus ON in 1, brainstem in 1, cerebral in 1, brainstem plus LETM in 1. 9 patients (45%) were AQP4 positive. 43 matched MS patients were included. In the baseline analysis grey matter volume was significantly lower in the MS group 0.55±0.1 (x106 mm3) compared to the NMO group 0.66±0.08 (p< 0.01). Whole brain volume (WBV), whole white matter volume (WWMV), left thalamic volume (LTV), right thalamic volume (RTV) and brainstem volume (BV) was similar in both. In the two year follow-up percent brain volume change (PBVC) was significantly higher in the MS group -0.88±0.2 (%) vs the NMO group -0.55±0.12 (p< 0.01). WBV was lower in the MS group 1.5±0.1 (x106 mm3) vs 1.6±0.13 (p< 0.01), GMV was also lower in the MS group 0.51±0.11 vs 0.65±0.09 (p< 0.01) as LTV 7±0.11 vs 7.5±0.4 (p< 0.01). There was no difference between BV or WVMV between groups. In the two year follow-up of the NMO patients there was a significant reduction in the BV 19.1±1.2 (cm3) in baseline vs 17.2±0.1 in follow-up (p< 0.01). There was no difference in the other variables.
Conclusion: MS patients showed significantly higher brain atrophy in baseline and follow-up. In NMOSD patients there was a significant reduction of brainstem volume in follow-up. These differences between groups may reflect different physiopathological mechanisms.
Disclosure: nothing to disclosure
Abstract: EP1510
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 19 Neurodegeneration
There are few studies regarding brain volume loss in Neuromyelitis optica spectrum disorder (NMOSD) with contradictory results. Our aim was to describe longitudinaly brain volume in a cohort of NMOSD patients compared to multiple sclerosis (MS) patients
Methods: Patients with diagnosis of NMOSD who had at least two MRI with a two year interval were included. MS patients matched by age and sex were included. SIENA and SIENAXr were used to measure brain volume.
Results: 20 NMOSD patients were included, 15 women (75%). Median age 39±12. The first symptom was longitudinally extensive transverse myelitis (LETM) in 9 (45%), optic neuritis (ON) in 7 (35%), LETM plus ON in 1, brainstem in 1, cerebral in 1, brainstem plus LETM in 1. 9 patients (45%) were AQP4 positive. 43 matched MS patients were included. In the baseline analysis grey matter volume was significantly lower in the MS group 0.55±0.1 (x106 mm3) compared to the NMO group 0.66±0.08 (p< 0.01). Whole brain volume (WBV), whole white matter volume (WWMV), left thalamic volume (LTV), right thalamic volume (RTV) and brainstem volume (BV) was similar in both. In the two year follow-up percent brain volume change (PBVC) was significantly higher in the MS group -0.88±0.2 (%) vs the NMO group -0.55±0.12 (p< 0.01). WBV was lower in the MS group 1.5±0.1 (x106 mm3) vs 1.6±0.13 (p< 0.01), GMV was also lower in the MS group 0.51±0.11 vs 0.65±0.09 (p< 0.01) as LTV 7±0.11 vs 7.5±0.4 (p< 0.01). There was no difference between BV or WVMV between groups. In the two year follow-up of the NMO patients there was a significant reduction in the BV 19.1±1.2 (cm3) in baseline vs 17.2±0.1 in follow-up (p< 0.01). There was no difference in the other variables.
Conclusion: MS patients showed significantly higher brain atrophy in baseline and follow-up. In NMOSD patients there was a significant reduction of brainstem volume in follow-up. These differences between groups may reflect different physiopathological mechanisms.
Disclosure: nothing to disclosure