Contributions
Abstract: EP1504
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 17 Environmental factors
Object: Vitamin D status is associated with the incidence and prevalence of a variety of neurologic disorders, including multiple sclerosis. Several studies suggest or support that multiple sclerosis has increased prevalence in geographic areas with lower sunlight levels. We aimed to investigate the correlation between vitamin D level and quality of life in patients with multiple sclerosis who were exposed to sunny seasons within one year in western Turkey.
Method: This follow-up study included 200 MS patients with a serum baseline 25(OH)D3 level, Expanded Disability Status Scale (EDSS) and multiple sclerosis quality of life questionnaire (MSQOL-54) with a follow-up of one year. Serum 25(OH)D was classified into the following categories: less than 25, 25-50, and 50 nmol/L or greater. Patients with vitamin D levels less than or equal 30ng/ml were administered vitamin D supplementation with an average weekly dose of 50.000 IU until vitamin D levels became normal, and then maintance daily dose of 4000 IU. All patients underwent interview and MSQOL-54was evaluated at baseline, 1 month, 3 months, 6 months, and 12 months after the beginning of vitamin D administration.
Results: Of 200 multiple sclerosis patients, 185 (92.5%) had lower vitamin D level. Patients reported no side effects during the study. The increase in Vitamin D level from baseline to 12 months was significant (p < 0.0001). The improvements remained significant in all categories of MSQOL-54 after the vitamin D administration (p< 0.001). According to our results, the longer vitamin D use the higher improvement of quality of life.
Conclusion: Little is known regarding the effect of vitamin D supplementation on quality of life. Also, the evidence for a beneficial effect of long-term vitamin D supplementation on health-related quality of life is lacking. This study showed that the prevalence of vitamin D level is still low in geographic areas with higher sunlight levels, and also, when vitamin D deficiency or insufficiency was corrected, there was indeed a positive effect on quality of life of patients.
Disclosure: nothing to disclose
Abstract: EP1504
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 17 Environmental factors
Object: Vitamin D status is associated with the incidence and prevalence of a variety of neurologic disorders, including multiple sclerosis. Several studies suggest or support that multiple sclerosis has increased prevalence in geographic areas with lower sunlight levels. We aimed to investigate the correlation between vitamin D level and quality of life in patients with multiple sclerosis who were exposed to sunny seasons within one year in western Turkey.
Method: This follow-up study included 200 MS patients with a serum baseline 25(OH)D3 level, Expanded Disability Status Scale (EDSS) and multiple sclerosis quality of life questionnaire (MSQOL-54) with a follow-up of one year. Serum 25(OH)D was classified into the following categories: less than 25, 25-50, and 50 nmol/L or greater. Patients with vitamin D levels less than or equal 30ng/ml were administered vitamin D supplementation with an average weekly dose of 50.000 IU until vitamin D levels became normal, and then maintance daily dose of 4000 IU. All patients underwent interview and MSQOL-54was evaluated at baseline, 1 month, 3 months, 6 months, and 12 months after the beginning of vitamin D administration.
Results: Of 200 multiple sclerosis patients, 185 (92.5%) had lower vitamin D level. Patients reported no side effects during the study. The increase in Vitamin D level from baseline to 12 months was significant (p < 0.0001). The improvements remained significant in all categories of MSQOL-54 after the vitamin D administration (p< 0.001). According to our results, the longer vitamin D use the higher improvement of quality of life.
Conclusion: Little is known regarding the effect of vitamin D supplementation on quality of life. Also, the evidence for a beneficial effect of long-term vitamin D supplementation on health-related quality of life is lacking. This study showed that the prevalence of vitamin D level is still low in geographic areas with higher sunlight levels, and also, when vitamin D deficiency or insufficiency was corrected, there was indeed a positive effect on quality of life of patients.
Disclosure: nothing to disclose