Contributions
Abstract: EP1497
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 15 Immunology
Background: Multiple sclerosis (MS) is known as a neuro-inflammatory disease of the central nervous system (CNS). The neuroinflammation may induce pro-inflammatory cytokines such as the Osteopontin (OPN). OPN plays an important role in the inflammation by regulating the THelper1 and THelper17 responses. Since diagnosis of multiple sclerosis is somewhat of a challenge, a reliable diagnostic biomarker that can be easily measured would be a great diagnostic method.
Objective: In this study we compared OPN plasma levels in adult relapsing remitting multiple sclerosis (RRMS) patients.
Method: In a case-control study, plasma was collected from the relapsing-remitting multiple sclerosis patients (RRMS) (n=36) as well as 35 age matched healthy individuals and a control group. Levels of OPN were measured and compared between the two groups.
Result: Mean OPN plasma levels was markedly higher in the case group (Mean [SEM], 4240[201.5] pg/ml) compared with the control group (3419[ 264.5])( p-value=0.008).
Conclusion: Significant higher OPN plasma levels in Relapsing-remitting multiple sclerosis patients suggest that OPN can be used as a diagnostic biomarker.
Keywords: Multiple Sclerosis, Relapsing-remitting multiple sclerosis, Osteopontin, Plasma
Disclosure:
Allahdadian sepideh: nothing to disclose
Alsahebfossul fereshteh: nothing to disclose
Etemadifar masoud: nothing to disclose
Abstract: EP1497
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 15 Immunology
Background: Multiple sclerosis (MS) is known as a neuro-inflammatory disease of the central nervous system (CNS). The neuroinflammation may induce pro-inflammatory cytokines such as the Osteopontin (OPN). OPN plays an important role in the inflammation by regulating the THelper1 and THelper17 responses. Since diagnosis of multiple sclerosis is somewhat of a challenge, a reliable diagnostic biomarker that can be easily measured would be a great diagnostic method.
Objective: In this study we compared OPN plasma levels in adult relapsing remitting multiple sclerosis (RRMS) patients.
Method: In a case-control study, plasma was collected from the relapsing-remitting multiple sclerosis patients (RRMS) (n=36) as well as 35 age matched healthy individuals and a control group. Levels of OPN were measured and compared between the two groups.
Result: Mean OPN plasma levels was markedly higher in the case group (Mean [SEM], 4240[201.5] pg/ml) compared with the control group (3419[ 264.5])( p-value=0.008).
Conclusion: Significant higher OPN plasma levels in Relapsing-remitting multiple sclerosis patients suggest that OPN can be used as a diagnostic biomarker.
Keywords: Multiple Sclerosis, Relapsing-remitting multiple sclerosis, Osteopontin, Plasma
Disclosure:
Allahdadian sepideh: nothing to disclose
Alsahebfossul fereshteh: nothing to disclose
Etemadifar masoud: nothing to disclose