Contributions
Abstract: EP1490
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 15 Immunology
Chemokines are inducible cytokines. Priorly they known as a chemotactic factors, but now they considered in various conditions. Fractalkine (CX3CL1) is a unique chemokine that can exist in a soluble form, as a chemotactic cytokine, or in a membrane-attached form that acts as a binding molecule. It is constituvely expressed in central nervous system (CNS).Especially on neurons, endothelial cells, microglias. Microglia are the main representatives of the immune system in the healthy brain. Inflammation and neuronal damage cause to increase levels of this chemokine. CX3CL1 can reduce neuroinflammation and has a neuroprotective role in CNS by reducing neurotoxicity and microglial activation.
The objective of this study is to analyze the link of fractalkine levels in NeuroBehcet's disease and multiple sclerosis (MS) for examine whether this chemokine has a possible diagnostic or a teuropathic target. Twenty NBD, 25 relapsing- remiting MS, 15 chronic progressive MS, 15 clinically isolated syndrome, 14 radiological isolated MS patients and 30 healthy controls have been included in this study. Serum samples has been measured using enzyme-linked immunosorbent assay (ELISA) method.
As a result, serum levels of CX3CL1 were significantly high in RRMS than other groups. Compared with healthy control groups there wasn' t any significant difference between NBD group but again in MS groups fractalkine levels were shown high levels.
These results suggest that, NBD is a nonspecific inflammatory condition compared to autoimmune mediated disorders such as MS. In literature fractalkine was studied especially in Alzheimer's disease and it was shown that CX3CL1 has various effects. It can suppres the production of nitric oxide (NO) . NO, related to the increased levels of IFN-γ and TNF-α. Also it released from hippocampal cells after excitotoxic insult has an essential role in brain protection by reducing against glutamate mediated excitotoxicity. Moreover CX3CL1/CX3CR1 regulate the activation of microglia by controlling the release of inflammatory cytokines and synaptic plasticity and cognitive functions by modulating receptors in neurons. Consequently in inflammatory conditions this chemokines has a noteworthy roles for neuroprotection and antiinflammation. We also shown that CX3CL1 has a possible target for monitoring the prognosis of MS patients and in future it will be a promissing new therapeutic target.
Disclosure: Ceyla Irkec et al.: Nothing to disclosure
Abstract: EP1490
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 15 Immunology
Chemokines are inducible cytokines. Priorly they known as a chemotactic factors, but now they considered in various conditions. Fractalkine (CX3CL1) is a unique chemokine that can exist in a soluble form, as a chemotactic cytokine, or in a membrane-attached form that acts as a binding molecule. It is constituvely expressed in central nervous system (CNS).Especially on neurons, endothelial cells, microglias. Microglia are the main representatives of the immune system in the healthy brain. Inflammation and neuronal damage cause to increase levels of this chemokine. CX3CL1 can reduce neuroinflammation and has a neuroprotective role in CNS by reducing neurotoxicity and microglial activation.
The objective of this study is to analyze the link of fractalkine levels in NeuroBehcet's disease and multiple sclerosis (MS) for examine whether this chemokine has a possible diagnostic or a teuropathic target. Twenty NBD, 25 relapsing- remiting MS, 15 chronic progressive MS, 15 clinically isolated syndrome, 14 radiological isolated MS patients and 30 healthy controls have been included in this study. Serum samples has been measured using enzyme-linked immunosorbent assay (ELISA) method.
As a result, serum levels of CX3CL1 were significantly high in RRMS than other groups. Compared with healthy control groups there wasn' t any significant difference between NBD group but again in MS groups fractalkine levels were shown high levels.
These results suggest that, NBD is a nonspecific inflammatory condition compared to autoimmune mediated disorders such as MS. In literature fractalkine was studied especially in Alzheimer's disease and it was shown that CX3CL1 has various effects. It can suppres the production of nitric oxide (NO) . NO, related to the increased levels of IFN-γ and TNF-α. Also it released from hippocampal cells after excitotoxic insult has an essential role in brain protection by reducing against glutamate mediated excitotoxicity. Moreover CX3CL1/CX3CR1 regulate the activation of microglia by controlling the release of inflammatory cytokines and synaptic plasticity and cognitive functions by modulating receptors in neurons. Consequently in inflammatory conditions this chemokines has a noteworthy roles for neuroprotection and antiinflammation. We also shown that CX3CL1 has a possible target for monitoring the prognosis of MS patients and in future it will be a promissing new therapeutic target.
Disclosure: Ceyla Irkec et al.: Nothing to disclosure