Contributions
Abstract: EP1484
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 15 Immunology
Introduction: There was a sharp increase of patients with peripheral nervous system (PNS) disorders such as Guillain-Barré Syndrome (GBS) and central nervous system (CNS) disorders after the outbreak of the arbovirus infections in Brazil. However, it is unclear which patient is at an increased risk to develop neurological complications after Zika (ZIKV), Chikungunya (CHIKV), and Dengue (DENV) infections.
Objective: To evaluate the seropositivity for ZIKV, CHIKV and DENV in patients with neurological complications after arboviruses infections, and assess antibodies against aquaporin-4 (AQP4) and myelin-oligodendrocyte glycoprotein (MOG).
Methods: We evaluated 35 patients from 2 centers in the Northeast of Brazil (Fortaleza and Recife) who presented with neuroimmunological disorders after arboviruses infection. We detected serum IgM and IgG antibodies against ZIKV, CHIK, DENV using ELISA kits. Anti-AQP4 and anti-MOG were tested using the cell-based assay.
Results: Among the total of 35 patients, the majority (n=21) had PNS manifestations - nineteen (90.4%) had GBS and two patients (9.5%) developed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Thirteen of 21 (61.9%) patients were positive for two viruses - 12/13 DENV+ZIKV and 1/13 DENV+CHIKV. Two of 21 (9%) patients were positive for all three viruses DENV+CHIKV+ZIKV. Six of 21 (28.6%) patients were positive only for DENV. The remaining 14/35 (40%) patients developed CNS complications (myelitis, encephalitis and optic neuritis). Eight of 14 (57%) patients had positivity for two or three viruses - 2/14 ZIKV+DENV, 3/14 CHIKV+DENV, 3/14 DENV+CHIKV+ZIKV. The remaining six patients were positive for one virus (5/14 DENV; 1/14 CHIKV). None of the patients had AQP4 antibodies and one patient was anti-MOG IgG positive (positive for ZIKV+DENV IgG).
Conclusion: Multiple viral infections may increase the risk of development of neurological complications. The development of autoantibodies such as anti-AQP4 and anti-MOG in those patients is rare.
Disclosure:
Rachel Dias Molina: nothing to disclose.
Ricardo Zalewsky: nothing to disclose.
Aline de Moura Brasil Matos: nothing to disclose.
Fernanda Martins Maia: nothing to disclose.
Rauli Costa Pires: nothing to disclose.
Danielle Malta Lima: nothing to disclose.
Solange Dornelas Mesquita: nothing to disclose.
Flávia Falcão Albuquerque: nothing to disclose.
Maria Lúcia Brito Ferreira: nothing to disclose.
Denise Cantarelli Machado: nothing to disclose.
Douglas Kazutoshi Sato: nothing to disclose.
Abstract: EP1484
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 15 Immunology
Introduction: There was a sharp increase of patients with peripheral nervous system (PNS) disorders such as Guillain-Barré Syndrome (GBS) and central nervous system (CNS) disorders after the outbreak of the arbovirus infections in Brazil. However, it is unclear which patient is at an increased risk to develop neurological complications after Zika (ZIKV), Chikungunya (CHIKV), and Dengue (DENV) infections.
Objective: To evaluate the seropositivity for ZIKV, CHIKV and DENV in patients with neurological complications after arboviruses infections, and assess antibodies against aquaporin-4 (AQP4) and myelin-oligodendrocyte glycoprotein (MOG).
Methods: We evaluated 35 patients from 2 centers in the Northeast of Brazil (Fortaleza and Recife) who presented with neuroimmunological disorders after arboviruses infection. We detected serum IgM and IgG antibodies against ZIKV, CHIK, DENV using ELISA kits. Anti-AQP4 and anti-MOG were tested using the cell-based assay.
Results: Among the total of 35 patients, the majority (n=21) had PNS manifestations - nineteen (90.4%) had GBS and two patients (9.5%) developed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Thirteen of 21 (61.9%) patients were positive for two viruses - 12/13 DENV+ZIKV and 1/13 DENV+CHIKV. Two of 21 (9%) patients were positive for all three viruses DENV+CHIKV+ZIKV. Six of 21 (28.6%) patients were positive only for DENV. The remaining 14/35 (40%) patients developed CNS complications (myelitis, encephalitis and optic neuritis). Eight of 14 (57%) patients had positivity for two or three viruses - 2/14 ZIKV+DENV, 3/14 CHIKV+DENV, 3/14 DENV+CHIKV+ZIKV. The remaining six patients were positive for one virus (5/14 DENV; 1/14 CHIKV). None of the patients had AQP4 antibodies and one patient was anti-MOG IgG positive (positive for ZIKV+DENV IgG).
Conclusion: Multiple viral infections may increase the risk of development of neurological complications. The development of autoantibodies such as anti-AQP4 and anti-MOG in those patients is rare.
Disclosure:
Rachel Dias Molina: nothing to disclose.
Ricardo Zalewsky: nothing to disclose.
Aline de Moura Brasil Matos: nothing to disclose.
Fernanda Martins Maia: nothing to disclose.
Rauli Costa Pires: nothing to disclose.
Danielle Malta Lima: nothing to disclose.
Solange Dornelas Mesquita: nothing to disclose.
Flávia Falcão Albuquerque: nothing to disclose.
Maria Lúcia Brito Ferreira: nothing to disclose.
Denise Cantarelli Machado: nothing to disclose.
Douglas Kazutoshi Sato: nothing to disclose.