Contributions
Abstract: EP1483
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 15 Immunology
Background: Neutrophil-to-lymphocyte ratio (NLR) is usually considered as a simple and cost effective parameter to evaluate inflammatory status. Studies have shown high NLR values in cases of acute or chronic inflammation, such as acute pancreatitis, chronic tonsillitis, acute mesenteric ischaemia, coronary artery disease, heart failure, diabetes mellitus, psoriasis and other malignancies. There are very few studies examining the relationship between multiple sclerosis (MS) and NLR.
Aims: The aim of this study was to investigate NLR in patients with MS in relapse and during remission.
Methods: In this study we analyzed data of patients with a diagnosis of MS according to revised Mc Donald criteria who admitted to our hospital between September 2016 and April 2017. Patients who have infection, chronic diseases such as diabetes mellitus, hypertension, malignancy, liver disorders, kidney disorders, other autoimmune diseases and patients recieving Fingolimod, Dimethyl fumarate and Natalizumab treatment were excluded from the study. Blood samples were collected before treatment with intravenous corticosteroids in patients with relapse. Complete blood counts as well as demographic and clinical data from MS patients were evaluated.
Results: Nintynine MS patients (36 patients in relapse; 63 patients in remission) were included in the study . The neutrophil count was significantly higher in patients who were in relapse than in patients in remission (5.90±2.88 x 109/L vs. 4.24±1.54 x 109/L; p = 0.001). Altough lymphoctye count was found higher in patients during relapse than in patients in remission (2.36±1.11 x 109/L vs. 2.06±0.7 x 109/L) this difference was not statistically significant (p=0.122). NLR was significantly higher in patients with relapse than patients in remission (3.79±0.6 vs. 1.26±0.17).
Conclusions: NLR may be a simple and inexpensive laboratory method to evaluate inflammmation in MS patients but further prospective studies with the high number of patients and long follow-up time are needed.
Disclosure:
Azize Esra Gürsoy: Nothing to disclose
Zehra Cemre Renk: Nothing to disclose
Talip Asil: Nothing to disclose
Abstract: EP1483
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 15 Immunology
Background: Neutrophil-to-lymphocyte ratio (NLR) is usually considered as a simple and cost effective parameter to evaluate inflammatory status. Studies have shown high NLR values in cases of acute or chronic inflammation, such as acute pancreatitis, chronic tonsillitis, acute mesenteric ischaemia, coronary artery disease, heart failure, diabetes mellitus, psoriasis and other malignancies. There are very few studies examining the relationship between multiple sclerosis (MS) and NLR.
Aims: The aim of this study was to investigate NLR in patients with MS in relapse and during remission.
Methods: In this study we analyzed data of patients with a diagnosis of MS according to revised Mc Donald criteria who admitted to our hospital between September 2016 and April 2017. Patients who have infection, chronic diseases such as diabetes mellitus, hypertension, malignancy, liver disorders, kidney disorders, other autoimmune diseases and patients recieving Fingolimod, Dimethyl fumarate and Natalizumab treatment were excluded from the study. Blood samples were collected before treatment with intravenous corticosteroids in patients with relapse. Complete blood counts as well as demographic and clinical data from MS patients were evaluated.
Results: Nintynine MS patients (36 patients in relapse; 63 patients in remission) were included in the study . The neutrophil count was significantly higher in patients who were in relapse than in patients in remission (5.90±2.88 x 109/L vs. 4.24±1.54 x 109/L; p = 0.001). Altough lymphoctye count was found higher in patients during relapse than in patients in remission (2.36±1.11 x 109/L vs. 2.06±0.7 x 109/L) this difference was not statistically significant (p=0.122). NLR was significantly higher in patients with relapse than patients in remission (3.79±0.6 vs. 1.26±0.17).
Conclusions: NLR may be a simple and inexpensive laboratory method to evaluate inflammmation in MS patients but further prospective studies with the high number of patients and long follow-up time are needed.
Disclosure:
Azize Esra Gürsoy: Nothing to disclose
Zehra Cemre Renk: Nothing to disclose
Talip Asil: Nothing to disclose