Contributions
Abstract: EP1476
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 14 Genetics/Epigenetics
Introduction: Multiple sclerosis (MS) is defined as a chronic, inflammatory, and demyelinating disease of the central nervous system. MS is more frequently diagnosed in women and in individuals aged between 20 and 40 years. MS is an autoimmune disease caused by genetic and environmental factors that may be accompanied by other autoimmune diseases. Among our patients, 177 (11.2%) had a history of MS in other members of the family. The incidence of MS in the families of MS patients is 5%-26%.
Results and conclusion: Based on the data obtained from hospitals, 1,787 patients were determined to be living in the Middle Black Sea Region and were diagnosed with MS. The clinical and radiological diagnoses of MS of 1,584 patients were confirmed, whereas the diagnoses of MS in 203 were withdrawn. The prevalence of MS in Samsun province was 46.5/100,000. It was 43.2/100,000 in the Middle Black Sea Region, which was calculated based on the total population and total number of patients in the provinces and districts (Table 1).
The mean ± standard deviation age of the patients was 38.2±10.9 years; 1,121 (70.8%) patients were females, while 463 (29.2%) were males. The mean age at disease onset was 29.3±7.6 years, with a mean age at disease onset of 29.33±7.5 years in females and 29.53±7.9 years in males.
A history of MS in other family members of patients was present in 177 (11.2%) patients. MS occurred in the sisters of 25 (14.1%) patients, mothers of 22 (12.4%) patients, brothers of 19 (10.7%) patients, daughters of 10 (5.7%) patients, fathers of 8 (4.5%) patients, and other relatives of 93 (52.5%) patients.
In the present study, familial MS was observed most often in second- and third-degree relatives. Among first-degree relatives, the frequency of familial MS was the highest in sisters, followed by mothers, brothers, daughters, and fathers. Although a higher frequency of familial MS in sisters and mothers is explained by the higher frequency of MS in women, some studies have reported a high rate of maternal inheritance of MS. A higher inheritance rate of familial MS in sisters than in mothers might be related to environmental factors. This can be explained by the fact that sisters and brothers are exposed to the same environmental factors during their childhood. The high frequency of familial MS in brothers in the present study might also support this opinion
Disclosure: nothing to disclose
Abstract: EP1476
Type: ePoster
Abstract Category: Pathology and pathogenesis of MS - 14 Genetics/Epigenetics
Introduction: Multiple sclerosis (MS) is defined as a chronic, inflammatory, and demyelinating disease of the central nervous system. MS is more frequently diagnosed in women and in individuals aged between 20 and 40 years. MS is an autoimmune disease caused by genetic and environmental factors that may be accompanied by other autoimmune diseases. Among our patients, 177 (11.2%) had a history of MS in other members of the family. The incidence of MS in the families of MS patients is 5%-26%.
Results and conclusion: Based on the data obtained from hospitals, 1,787 patients were determined to be living in the Middle Black Sea Region and were diagnosed with MS. The clinical and radiological diagnoses of MS of 1,584 patients were confirmed, whereas the diagnoses of MS in 203 were withdrawn. The prevalence of MS in Samsun province was 46.5/100,000. It was 43.2/100,000 in the Middle Black Sea Region, which was calculated based on the total population and total number of patients in the provinces and districts (Table 1).
The mean ± standard deviation age of the patients was 38.2±10.9 years; 1,121 (70.8%) patients were females, while 463 (29.2%) were males. The mean age at disease onset was 29.3±7.6 years, with a mean age at disease onset of 29.33±7.5 years in females and 29.53±7.9 years in males.
A history of MS in other family members of patients was present in 177 (11.2%) patients. MS occurred in the sisters of 25 (14.1%) patients, mothers of 22 (12.4%) patients, brothers of 19 (10.7%) patients, daughters of 10 (5.7%) patients, fathers of 8 (4.5%) patients, and other relatives of 93 (52.5%) patients.
In the present study, familial MS was observed most often in second- and third-degree relatives. Among first-degree relatives, the frequency of familial MS was the highest in sisters, followed by mothers, brothers, daughters, and fathers. Although a higher frequency of familial MS in sisters and mothers is explained by the higher frequency of MS in women, some studies have reported a high rate of maternal inheritance of MS. A higher inheritance rate of familial MS in sisters than in mothers might be related to environmental factors. This can be explained by the fact that sisters and brothers are exposed to the same environmental factors during their childhood. The high frequency of familial MS in brothers in the present study might also support this opinion
Disclosure: nothing to disclose