Contributions
Abstract: EP1444
Type: ePoster
Abstract Category: Clinical aspects of MS - 11 Comorbidity
Background: MS is a complex illness with the wide range of symptoms. The MS subtype can be categorized, however, individual disease characteristics are variable. Comorbidity and other individual features such as smoking, alcohol or drug use status in MS patients may contribute to the factors associated with the outcomes, disability levels and the burden of the disease.
Objectives: We evaluated the frequencies of tobacco, alcohol, drug use together with existance of other diseases than MS in our study group. Moreover, we explored the relationship between demographic and clinical MS characteristics and smoking, alcohol or drug use status, levels of fatigue, subjective quality of life (QOL) and various comorbidities.
Materials and methods: Totally, 125 patients filled in the questionnaire about tobacco, alcohol, drug use together with data about other diseases than MS and the SF-36 scale. Two measures of physical (PCS) and mental (MCS) health were calculated, and the fatigue was evaluated in the 10-point scale. Demographic and clinical data with the Expanded Disability Status Scale (EDSS) scores were collected.
Results: Women comprised 70.4% of the group, and men-29.6%. The mean of the age was 41.1±11.8 years. The mean EDSS score was 2.92±1.32. The majority of the patients had a relapsing-remitting MS (97.6%). Firstly, 20% of patients had arterial hypertension (AH), 8.8% had dyslipidemia, 1.6% had diabetes mellitus (DM), and 5.6% - pulmonary diseases. Secondly, 16% reported depression, and 12% - anxiety disorder. In total, 15% of patients were smoking, and 2.4% reported drug use. The mean alcohol use was 1.14±2.12 alcohol units per month. The mean scores of PCS were 53.06±19.83, and of MCS 53.14±18.26, accordingly. The mean score of fatigue was 6.02±2.25. There was no association between comorbidity, disease course and EDSS (p>0.05). Fatigue measures were higher in patients with AH, depression and drug use, also measures of PCS were lower in patients with depression and dyslipidemia, and the measures of MCS were lower in patients with depression and anxiety (p< 0.05). We found the higher relapses rate in patients with dyslipidemia (p=0.039). There was no association with mean alcohol consumption and clinical MS parameters, QOL and fatigue.
Conclusions: Our study showed that comorbidity in MS affects levels of fatigue and subjective QOL. We found the association with relapse rate and dyslipidemia. We plan to continue this study and expand the cohort.
Disclosure:
Egle Sukockiene: nothing to disclose
Birute Dirziuviene: nothing to disclose
Dalia Mickeviciene: nothing to disclose
Renata Balnyte: nothing to disclose
Simonas Jesmanas: nothing to disclose
Gabriele Adomaviciute: nothing to disclose
Abstract: EP1444
Type: ePoster
Abstract Category: Clinical aspects of MS - 11 Comorbidity
Background: MS is a complex illness with the wide range of symptoms. The MS subtype can be categorized, however, individual disease characteristics are variable. Comorbidity and other individual features such as smoking, alcohol or drug use status in MS patients may contribute to the factors associated with the outcomes, disability levels and the burden of the disease.
Objectives: We evaluated the frequencies of tobacco, alcohol, drug use together with existance of other diseases than MS in our study group. Moreover, we explored the relationship between demographic and clinical MS characteristics and smoking, alcohol or drug use status, levels of fatigue, subjective quality of life (QOL) and various comorbidities.
Materials and methods: Totally, 125 patients filled in the questionnaire about tobacco, alcohol, drug use together with data about other diseases than MS and the SF-36 scale. Two measures of physical (PCS) and mental (MCS) health were calculated, and the fatigue was evaluated in the 10-point scale. Demographic and clinical data with the Expanded Disability Status Scale (EDSS) scores were collected.
Results: Women comprised 70.4% of the group, and men-29.6%. The mean of the age was 41.1±11.8 years. The mean EDSS score was 2.92±1.32. The majority of the patients had a relapsing-remitting MS (97.6%). Firstly, 20% of patients had arterial hypertension (AH), 8.8% had dyslipidemia, 1.6% had diabetes mellitus (DM), and 5.6% - pulmonary diseases. Secondly, 16% reported depression, and 12% - anxiety disorder. In total, 15% of patients were smoking, and 2.4% reported drug use. The mean alcohol use was 1.14±2.12 alcohol units per month. The mean scores of PCS were 53.06±19.83, and of MCS 53.14±18.26, accordingly. The mean score of fatigue was 6.02±2.25. There was no association between comorbidity, disease course and EDSS (p>0.05). Fatigue measures were higher in patients with AH, depression and drug use, also measures of PCS were lower in patients with depression and dyslipidemia, and the measures of MCS were lower in patients with depression and anxiety (p< 0.05). We found the higher relapses rate in patients with dyslipidemia (p=0.039). There was no association with mean alcohol consumption and clinical MS parameters, QOL and fatigue.
Conclusions: Our study showed that comorbidity in MS affects levels of fatigue and subjective QOL. We found the association with relapse rate and dyslipidemia. We plan to continue this study and expand the cohort.
Disclosure:
Egle Sukockiene: nothing to disclose
Birute Dirziuviene: nothing to disclose
Dalia Mickeviciene: nothing to disclose
Renata Balnyte: nothing to disclose
Simonas Jesmanas: nothing to disclose
Gabriele Adomaviciute: nothing to disclose