Contributions
Abstract: EP1435
Type: ePoster
Abstract Category: Clinical aspects of MS - 11 Comorbidity
Background: Among patients with neuromyelitis optica spectrum disorder (NMOSD), sleep abnormalities, fatigue and mood disorders are common comorbidities that can impair quality of life if they are not correctly identified.
Goals: To evaluate the frequency of sleep disorders, fatigue and depression in a Brazilian cohort of patients with NMOSD.
Methods: Between September 2014 and December 2016, 66 patients with NMOSD were interviewed, in a cross-sectional study. Sleep disorders, fatigue and depression were evaluated through specific questionnaires: Pittsburgh index for sleep quality, restless legs syndrome severity scale, fatigue severity scale, Beck's depression inventory, Epworth scale, and Berlin questionnaire. Unpaired t test or Mann-Whitney test were used for comparing NMOIgG positive and negative patients. A logistic regression model was built to investigate factors associated to the quality of sleep.
Results: Mean age of disease onset was 33,85 (±13,5), with median disease duration of 9,03 (±5,5) years; 50% were Afro-descendants with a 4:1 female:male rate. A complete NMO syndrome (with 2 of the core symptoms: optic neuritis, longitudinal extensive transverse myelitis and/or area postrema syndrome) were observed in 77% of the patients. Only 18 (27%) patients presented a good sleep quality; 35% had excessive daytime sleepiness; 30% were at high risk for presenting obstructive sleep apnea syndrome; 15% had moderate to severe restless legs syndrome; 62% had depression, and 33% had moderate to severe fatigue. When NMOIgG positive patients (n= 32) and negative (n = 30) were compared, no difference was observed between the two groups. The regression model showed only age was significantly associated with poor quality of sleep (coef 0.84, p=0.03).
Conclusion: Sleep disorders and depression are frequent among patients with NMOSD, regardless their NMOIgG status. Older patients seem to have a poor quality of sleep.
Disclosure:
Perin MMM has been awarded an educational grant by Bayer Health Care to study for an online Masters in Neuorimmunologiy at Universitat Autònoma de Barcelona (UAB), has received speaking honoraria from Novartis and financial assistance to attend neurology congress paid by Bayer Health Care, Merck Serono and TEVA.
Bichuetti DB has received speaking/consulting honoraria from Bayer Health Care, Biogen Idec, Merck Serono, Genzyme-Sanofi and TEVA and had travel expenses to scientific meetings sponsored by Bayer Health Care, Merck Serono, TEVA and Roche.
Souza NA had travel expenses to scientific meetings paid by Bayer Health Care, Merck Serono and TEVA.
Oliveira EML has received speaking/consulting honoraria from Novartis, Biogen Idec, Merck Serono, Genzyme Sanofi and TEVA and had travel expenses to scientific meetings sponsored by Novartis, Genzyme Sanofi, Merck Serono and TEVA.
Abstract: EP1435
Type: ePoster
Abstract Category: Clinical aspects of MS - 11 Comorbidity
Background: Among patients with neuromyelitis optica spectrum disorder (NMOSD), sleep abnormalities, fatigue and mood disorders are common comorbidities that can impair quality of life if they are not correctly identified.
Goals: To evaluate the frequency of sleep disorders, fatigue and depression in a Brazilian cohort of patients with NMOSD.
Methods: Between September 2014 and December 2016, 66 patients with NMOSD were interviewed, in a cross-sectional study. Sleep disorders, fatigue and depression were evaluated through specific questionnaires: Pittsburgh index for sleep quality, restless legs syndrome severity scale, fatigue severity scale, Beck's depression inventory, Epworth scale, and Berlin questionnaire. Unpaired t test or Mann-Whitney test were used for comparing NMOIgG positive and negative patients. A logistic regression model was built to investigate factors associated to the quality of sleep.
Results: Mean age of disease onset was 33,85 (±13,5), with median disease duration of 9,03 (±5,5) years; 50% were Afro-descendants with a 4:1 female:male rate. A complete NMO syndrome (with 2 of the core symptoms: optic neuritis, longitudinal extensive transverse myelitis and/or area postrema syndrome) were observed in 77% of the patients. Only 18 (27%) patients presented a good sleep quality; 35% had excessive daytime sleepiness; 30% were at high risk for presenting obstructive sleep apnea syndrome; 15% had moderate to severe restless legs syndrome; 62% had depression, and 33% had moderate to severe fatigue. When NMOIgG positive patients (n= 32) and negative (n = 30) were compared, no difference was observed between the two groups. The regression model showed only age was significantly associated with poor quality of sleep (coef 0.84, p=0.03).
Conclusion: Sleep disorders and depression are frequent among patients with NMOSD, regardless their NMOIgG status. Older patients seem to have a poor quality of sleep.
Disclosure:
Perin MMM has been awarded an educational grant by Bayer Health Care to study for an online Masters in Neuorimmunologiy at Universitat Autònoma de Barcelona (UAB), has received speaking honoraria from Novartis and financial assistance to attend neurology congress paid by Bayer Health Care, Merck Serono and TEVA.
Bichuetti DB has received speaking/consulting honoraria from Bayer Health Care, Biogen Idec, Merck Serono, Genzyme-Sanofi and TEVA and had travel expenses to scientific meetings sponsored by Bayer Health Care, Merck Serono, TEVA and Roche.
Souza NA had travel expenses to scientific meetings paid by Bayer Health Care, Merck Serono and TEVA.
Oliveira EML has received speaking/consulting honoraria from Novartis, Biogen Idec, Merck Serono, Genzyme Sanofi and TEVA and had travel expenses to scientific meetings sponsored by Novartis, Genzyme Sanofi, Merck Serono and TEVA.