Contributions
Abstract: EP1433
Type: ePoster
Abstract Category: Clinical aspects of MS - 10 Neuro-ophthalmology
Introduction: Visual evoked potentials (VEPs) have long been used to investigate patients with optic neuropathies. They complement the structural information given by magnetic resonance imaging and clinical assessment of visual acuity by detecting functional loss in the visual pathway. The analysis of VEPs amplitudes and latencies may aid in the differential diagnosis.
Methods: 115 patients admitted in our hospital with suspected optic neuropathy were selected. According to current diagnosis criteria, 4 etiological groups were defined: Multiple sclerosis (MS) (N=36), Neuromyelitis optica (NMO) (N=8), Idiopathic (N= 57), Ischemic (N=9). We analysed VEPs performed in the acute phase and compared these results according to the final diagnosis.
Results: 110 patients and 220 eyes were selected. Fourteen patients had bilateral symptoms (N=2 MS, N=9 Idiopathic, N=3 NMO). The VEP analysis showed visual pathway abnormalities in sixty-nine eyes, and none of these were asymptomatic. Mean P100 latency differed among groups (p=0,0023), with those diagnosed with MS and NMO showing prolonged latencies, respectively 139 (IQR=30,5) and 126. Analysis of P100 amplitudes did not show significant differences (p=0.0852). NMO and ischemic optic neuropathies were associated with a greater proportion of absence visual evoked responses: 50% and 37.5%, respectively, compared with 16.0% in MS (p=0.013).
Conclusion: Recently a new role for VEPs in MS has been suggested. They are advocated as possible diagnosis and prognostic biomarkers. Nevertheless, their value extends beyond MS and they may help differentiating this entity and NMO or ischemic neuropathies. Our study further confirms previous reports of utility of PEVs in differentiating the etiology of optic neuropathies with different profiles.
Disclosure:
Mafalda Seabra: nothing to disclose
Luis Braz: nothing to disclose
Joana Guimarães: nothing to disclose
Abstract: EP1433
Type: ePoster
Abstract Category: Clinical aspects of MS - 10 Neuro-ophthalmology
Introduction: Visual evoked potentials (VEPs) have long been used to investigate patients with optic neuropathies. They complement the structural information given by magnetic resonance imaging and clinical assessment of visual acuity by detecting functional loss in the visual pathway. The analysis of VEPs amplitudes and latencies may aid in the differential diagnosis.
Methods: 115 patients admitted in our hospital with suspected optic neuropathy were selected. According to current diagnosis criteria, 4 etiological groups were defined: Multiple sclerosis (MS) (N=36), Neuromyelitis optica (NMO) (N=8), Idiopathic (N= 57), Ischemic (N=9). We analysed VEPs performed in the acute phase and compared these results according to the final diagnosis.
Results: 110 patients and 220 eyes were selected. Fourteen patients had bilateral symptoms (N=2 MS, N=9 Idiopathic, N=3 NMO). The VEP analysis showed visual pathway abnormalities in sixty-nine eyes, and none of these were asymptomatic. Mean P100 latency differed among groups (p=0,0023), with those diagnosed with MS and NMO showing prolonged latencies, respectively 139 (IQR=30,5) and 126. Analysis of P100 amplitudes did not show significant differences (p=0.0852). NMO and ischemic optic neuropathies were associated with a greater proportion of absence visual evoked responses: 50% and 37.5%, respectively, compared with 16.0% in MS (p=0.013).
Conclusion: Recently a new role for VEPs in MS has been suggested. They are advocated as possible diagnosis and prognostic biomarkers. Nevertheless, their value extends beyond MS and they may help differentiating this entity and NMO or ischemic neuropathies. Our study further confirms previous reports of utility of PEVs in differentiating the etiology of optic neuropathies with different profiles.
Disclosure:
Mafalda Seabra: nothing to disclose
Luis Braz: nothing to disclose
Joana Guimarães: nothing to disclose