Contributions
Abstract: EP1427
Type: ePoster
Abstract Category: Clinical aspects of MS - 9 Economic burden
Background: Primary progressive multiple sclerosis (PPMS) is characterized by steadily increasing neurologic disability from disease onset, with or without temporary plateaus in disease progression. PPMS is a chronic disease that primarily affects patients of working age; however, there is a lack of data on the impact PPMS has on patients' work productivity and ability to live independently.
Goals: To compare the ability to perform daily self-care activities, work productivity, and reliance on caregiver between patients who have PPMS and patients who have relapsing remitting MS (RRMS).
Methods: This study used data from the patient record form (PRF) of the Adelphi Multiple Sclerosis Disease Specific Programme, a cross-sectional study collecting data from 487 neurologists and 5402 patients in the France, Germany, Italy, Spain, United Kingdom, and United States between November 2015 and March 2016. A total of 916 PPMS and 3,472 RRMS patients were included. Self-care activities were assessed by activities of daily living (ADL) and instrumental activities of daily living (IADL). Productivity and independency were examined by whether a patient was able to work full time and whether he/she had a caregiver, respectively. Adjusted analyses were performed to control for potential confounders.
Results: PPMS patients were older (51.2 vs. 38.1, p< 0.001), more likely to be males (54.8% vs. 31.8%, p< 0.001), had a longer disease duration (7.0 vs. 4.6 years, p< 0.001), had a higher Expanded Disability Status Scale (EDSS) score (4.9 vs. 2.1, p< 0.001), and were less likely to be on a current treatment with a DMT (36.7% vs. 83.4%, p< 0.001) than RRMS patients. Compared to RRMS, a higher proportion of PPMS patients needed assist on at least one ADL (45.0% vs. 6.4%, p< 0.001) and IADL (62.2% vs. 15.2%, p< 0.001). In addition, PPMS patients were less likely to work full time than RRMS patients (18.8% vs. 52.3%, p< 0.001). Finally, a higher reliance on professional caregiver (18.2% vs. 1.4%,
p< 0.001) and family caregiver (53.7% vs. 16.7%, p< 0.001) was observed in PPMS than in RRMS.
In adjusted analyses, all of the above findings were consistent after controlling for confounders.
Conclusions: Compared with RRMS patients, PPMS patients had a significantly higher burden on their ability to perform self-care activities, work full time, and live independently. These findings highlight the high unmet need in PPMS for an effective DMT.
Disclosure: Funded by Genentech, Inc.
N. Wu is an employee of Genentech, Inc.
N. Thomas is an employee and shareholder of Genentech, Inc.
E. Ma is an employee and shareholder of Genentech, Inc.
W-S Yeh is an employee and shareholder of Genentech, Inc.
E. Jones has no conflict of interest and is a paid employee of Adelphi Real World
Abstract: EP1427
Type: ePoster
Abstract Category: Clinical aspects of MS - 9 Economic burden
Background: Primary progressive multiple sclerosis (PPMS) is characterized by steadily increasing neurologic disability from disease onset, with or without temporary plateaus in disease progression. PPMS is a chronic disease that primarily affects patients of working age; however, there is a lack of data on the impact PPMS has on patients' work productivity and ability to live independently.
Goals: To compare the ability to perform daily self-care activities, work productivity, and reliance on caregiver between patients who have PPMS and patients who have relapsing remitting MS (RRMS).
Methods: This study used data from the patient record form (PRF) of the Adelphi Multiple Sclerosis Disease Specific Programme, a cross-sectional study collecting data from 487 neurologists and 5402 patients in the France, Germany, Italy, Spain, United Kingdom, and United States between November 2015 and March 2016. A total of 916 PPMS and 3,472 RRMS patients were included. Self-care activities were assessed by activities of daily living (ADL) and instrumental activities of daily living (IADL). Productivity and independency were examined by whether a patient was able to work full time and whether he/she had a caregiver, respectively. Adjusted analyses were performed to control for potential confounders.
Results: PPMS patients were older (51.2 vs. 38.1, p< 0.001), more likely to be males (54.8% vs. 31.8%, p< 0.001), had a longer disease duration (7.0 vs. 4.6 years, p< 0.001), had a higher Expanded Disability Status Scale (EDSS) score (4.9 vs. 2.1, p< 0.001), and were less likely to be on a current treatment with a DMT (36.7% vs. 83.4%, p< 0.001) than RRMS patients. Compared to RRMS, a higher proportion of PPMS patients needed assist on at least one ADL (45.0% vs. 6.4%, p< 0.001) and IADL (62.2% vs. 15.2%, p< 0.001). In addition, PPMS patients were less likely to work full time than RRMS patients (18.8% vs. 52.3%, p< 0.001). Finally, a higher reliance on professional caregiver (18.2% vs. 1.4%,
p< 0.001) and family caregiver (53.7% vs. 16.7%, p< 0.001) was observed in PPMS than in RRMS.
In adjusted analyses, all of the above findings were consistent after controlling for confounders.
Conclusions: Compared with RRMS patients, PPMS patients had a significantly higher burden on their ability to perform self-care activities, work full time, and live independently. These findings highlight the high unmet need in PPMS for an effective DMT.
Disclosure: Funded by Genentech, Inc.
N. Wu is an employee of Genentech, Inc.
N. Thomas is an employee and shareholder of Genentech, Inc.
E. Ma is an employee and shareholder of Genentech, Inc.
W-S Yeh is an employee and shareholder of Genentech, Inc.
E. Jones has no conflict of interest and is a paid employee of Adelphi Real World