Contributions
Abstract: EP1418
Type: ePoster
Abstract Category: Clinical aspects of MS - 8 Clinical assessment tools
Introduction: Multiple sclerosis (MS) is an inflammatory demyelinating disease of central nervous system (CNS). Acute idiopathic demyelinating optic neuritis is frequently the initial manifestation. In this study, we aimed to discuss the value of color vision testing to detect possible optic nerve involvement in patients with MS who had no history of optic neuritis.
Methods: 28 RRMS patients with 56 eyes and age-sex matched 25 healthy controls with 50 eyes were included to this study. We evaluated color vision with Farnsworth-Munsell 100 hue test and retinal nerve fiber layer thickness (RNFL) was determined by optical coherence tomography (OCT). Pattern visual evoked potentials (PVEP) were also performed. EDSS scores, duration of disease, history of treatment were all recorded.
Results: 28 RRMS patients (mean age 39,68±9,68) and 25 healthy controls (mean age 38±5,94) were included. In patient group, 20 were female (71,4%), 8 were male (28,6%). Control group contained 17 female (68%), 8 male (32%). P100 latencies were significantly delayed in patient group than controls. (p=< 0.05). In patient group mean RNFL thickness was 85.79±13.8µm while the thickness of RNFL was 89.24±8.55 µm in controls. Mean temporal RNFL thickness was 57.64±14.13 µm in patients and 67.64±11.68 µm in controls. Statistically significant thinning was found in temporal quadrant in patient groups than controls (p=0.002). There was a negative correlation between the total error scores and RNFL thickness in patient group (p=0,016; r:-0,320). There were also negative correlations between the red green-blue yellow scores and temporal quadrant thickness in patient group, respectively (p=0,006;r:-363,p=0,004; r: -0,383).
Conclusion: This ongoing study showed that PVEP, OCT parameters, Farnsworth-Munsell 100 hue test were all correlated to detect subclinical optic pathway involvement in multiple sclerosis patients.
Disclosure: None of the authors identify a conflict of interest. This research did not receive any grant from funding agencies.
Abstract: EP1418
Type: ePoster
Abstract Category: Clinical aspects of MS - 8 Clinical assessment tools
Introduction: Multiple sclerosis (MS) is an inflammatory demyelinating disease of central nervous system (CNS). Acute idiopathic demyelinating optic neuritis is frequently the initial manifestation. In this study, we aimed to discuss the value of color vision testing to detect possible optic nerve involvement in patients with MS who had no history of optic neuritis.
Methods: 28 RRMS patients with 56 eyes and age-sex matched 25 healthy controls with 50 eyes were included to this study. We evaluated color vision with Farnsworth-Munsell 100 hue test and retinal nerve fiber layer thickness (RNFL) was determined by optical coherence tomography (OCT). Pattern visual evoked potentials (PVEP) were also performed. EDSS scores, duration of disease, history of treatment were all recorded.
Results: 28 RRMS patients (mean age 39,68±9,68) and 25 healthy controls (mean age 38±5,94) were included. In patient group, 20 were female (71,4%), 8 were male (28,6%). Control group contained 17 female (68%), 8 male (32%). P100 latencies were significantly delayed in patient group than controls. (p=< 0.05). In patient group mean RNFL thickness was 85.79±13.8µm while the thickness of RNFL was 89.24±8.55 µm in controls. Mean temporal RNFL thickness was 57.64±14.13 µm in patients and 67.64±11.68 µm in controls. Statistically significant thinning was found in temporal quadrant in patient groups than controls (p=0.002). There was a negative correlation between the total error scores and RNFL thickness in patient group (p=0,016; r:-0,320). There were also negative correlations between the red green-blue yellow scores and temporal quadrant thickness in patient group, respectively (p=0,006;r:-363,p=0,004; r: -0,383).
Conclusion: This ongoing study showed that PVEP, OCT parameters, Farnsworth-Munsell 100 hue test were all correlated to detect subclinical optic pathway involvement in multiple sclerosis patients.
Disclosure: None of the authors identify a conflict of interest. This research did not receive any grant from funding agencies.