Contributions
Abstract: EP1417
Type: ePoster
Abstract Category: Clinical aspects of MS - 8 Clinical assessment tools
Objective: To investigate the reliability, validity and responsiveness to change of the Human Activity Profile (HAP), a self-report questionnaire measuring physical activity, in patients with multiple sclerosis (MS).
Methods: Group of 25 patients with MS completed the following self-report questionnaires: HAP, Modified Fatigue Impact Scale (MFIS), Multiple Sclerosis Quality of Life-54 (MSQOL54). EDSS disability level was determined and walking speed assessed by 10-Meter Walking test (10MWT).
Responses on the HAP resulted in 2 scores: maximum activity score (MAS) and adjusted activity score (AAS). These scores were statistically correlated with the other tests and examined for test-retest reliability. A subset of patients (12) participated in a 12-week supervised aerobic exercise programme, while others served as control. Same measures were repeated at end of 12 weeks.
Results: Intraclass correlation coefficient (ICC), calculated on control group, was 0,97 for both MAS and AAS. Significant correlations were found between HAP scores and subscale scores from MFIS and MSQOL54, that assess physical functioning, EDSS and 10MWT. After 12 weeks of exercise, a decrease of physical fatigue, as measured by Body subscale of MFIS (MFIS-B), was found, although not statistically significant (p=0,054). A statistically significant increase in Energy subscale of MSQOL54 (MSQOL54-E; p=0,022) was reported by control group. No significant correlation between MFIS-B and MSQOL54-E was found. In both groups, no statistically significant change was observed in HAP, EDSS and 10MWT. In response to 12 weeks of exercise, the effect sizes for MAS and AAS were 0,2 and 0,04, respectively, similar to that of the MFIS and MSQOL54.
Conclusion: The correlations between HAP and physical function subscale scores from MFIS and MSQOL54, EDSS and 10MWT demonstrate that HAP is a valid and, as demonstrated by ICCs, also a reliable measure of physical function in patients with MS. After 12 weeks of exercise, no major change in physical functioning was detected by any of the measures. HAP displays a similar sensitivity to change as the other questionnaires. Along with simplicity of use, HAP could be a valuable assessment tool for patients with MS.
Disclosure: Lina Savsek: nothing to disclose. Vojko Strojnik: nothing to disclose. Ziga Spiclin: nothing to disclose. Sasa Sega Jazbec: nothing to disclose.
Abstract: EP1417
Type: ePoster
Abstract Category: Clinical aspects of MS - 8 Clinical assessment tools
Objective: To investigate the reliability, validity and responsiveness to change of the Human Activity Profile (HAP), a self-report questionnaire measuring physical activity, in patients with multiple sclerosis (MS).
Methods: Group of 25 patients with MS completed the following self-report questionnaires: HAP, Modified Fatigue Impact Scale (MFIS), Multiple Sclerosis Quality of Life-54 (MSQOL54). EDSS disability level was determined and walking speed assessed by 10-Meter Walking test (10MWT).
Responses on the HAP resulted in 2 scores: maximum activity score (MAS) and adjusted activity score (AAS). These scores were statistically correlated with the other tests and examined for test-retest reliability. A subset of patients (12) participated in a 12-week supervised aerobic exercise programme, while others served as control. Same measures were repeated at end of 12 weeks.
Results: Intraclass correlation coefficient (ICC), calculated on control group, was 0,97 for both MAS and AAS. Significant correlations were found between HAP scores and subscale scores from MFIS and MSQOL54, that assess physical functioning, EDSS and 10MWT. After 12 weeks of exercise, a decrease of physical fatigue, as measured by Body subscale of MFIS (MFIS-B), was found, although not statistically significant (p=0,054). A statistically significant increase in Energy subscale of MSQOL54 (MSQOL54-E; p=0,022) was reported by control group. No significant correlation between MFIS-B and MSQOL54-E was found. In both groups, no statistically significant change was observed in HAP, EDSS and 10MWT. In response to 12 weeks of exercise, the effect sizes for MAS and AAS were 0,2 and 0,04, respectively, similar to that of the MFIS and MSQOL54.
Conclusion: The correlations between HAP and physical function subscale scores from MFIS and MSQOL54, EDSS and 10MWT demonstrate that HAP is a valid and, as demonstrated by ICCs, also a reliable measure of physical function in patients with MS. After 12 weeks of exercise, no major change in physical functioning was detected by any of the measures. HAP displays a similar sensitivity to change as the other questionnaires. Along with simplicity of use, HAP could be a valuable assessment tool for patients with MS.
Disclosure: Lina Savsek: nothing to disclose. Vojko Strojnik: nothing to disclose. Ziga Spiclin: nothing to disclose. Sasa Sega Jazbec: nothing to disclose.