Contributions
Abstract: EP1415
Type: ePoster
Abstract Category: Clinical aspects of MS - 8 Clinical assessment tools
Background and purpose: The epidemiological studies confirm an increased risk of cardiovascular disease in multiple sclerosis and epicardial adipose tissue (EAT), a type of visceral adipose tissue surrounding the heart and coronary vessels has been implicated in the development of coronary artery disease. We sought to investigate the correlation between EAT and the disease - disease severity in multiple sclerosis (MS) patients.
Methods: Twenty eight multiple sclerosis (MS) patients (MS duration 8 (4-16) years, aged 41 ± 16 years; female/male: 16/10) and 28 healthy controls both with no known cardiovascular risk factors were enrolled into the study. Disease severity was evaluated by Extended Disability Status Scale (EDSS). The EAT was measured via two-dimensional (2D) M-mode echocardiography.
Results: EFT was significantly higher in patients compared to controls (3.6 ±1.2 mm vs. 3.1 ± 0.7 mm, P < 0.05). We did not observe correlations between the EFT levels and MS duration, relapses, EDSS, optic neuritis, oligoclonal bands (p>0.05).
Conclusions: The reason for the increase in EAT in patients with MS is unknown, but it is probably multifactorial, with genetic, immune-mediated inflammatory factors having a role. Thus, along with the increased prevalence of cardiometabolic risk factors and systemic inflammation, EAT can probably be another important contributor to the higher cardiovascular risk observed in MS. These findings deserve to be studied closer in a broader spectrum of comorbidities in MS.
Disclosure: No conflict of interest
Abstract: EP1415
Type: ePoster
Abstract Category: Clinical aspects of MS - 8 Clinical assessment tools
Background and purpose: The epidemiological studies confirm an increased risk of cardiovascular disease in multiple sclerosis and epicardial adipose tissue (EAT), a type of visceral adipose tissue surrounding the heart and coronary vessels has been implicated in the development of coronary artery disease. We sought to investigate the correlation between EAT and the disease - disease severity in multiple sclerosis (MS) patients.
Methods: Twenty eight multiple sclerosis (MS) patients (MS duration 8 (4-16) years, aged 41 ± 16 years; female/male: 16/10) and 28 healthy controls both with no known cardiovascular risk factors were enrolled into the study. Disease severity was evaluated by Extended Disability Status Scale (EDSS). The EAT was measured via two-dimensional (2D) M-mode echocardiography.
Results: EFT was significantly higher in patients compared to controls (3.6 ±1.2 mm vs. 3.1 ± 0.7 mm, P < 0.05). We did not observe correlations between the EFT levels and MS duration, relapses, EDSS, optic neuritis, oligoclonal bands (p>0.05).
Conclusions: The reason for the increase in EAT in patients with MS is unknown, but it is probably multifactorial, with genetic, immune-mediated inflammatory factors having a role. Thus, along with the increased prevalence of cardiometabolic risk factors and systemic inflammation, EAT can probably be another important contributor to the higher cardiovascular risk observed in MS. These findings deserve to be studied closer in a broader spectrum of comorbidities in MS.
Disclosure: No conflict of interest