Abstract: EP1412
Type: ePoster
Abstract Category: Clinical aspects of MS - 8 Clinical assessment tools
Background: Cognitive Impairment (CI) raises concerns since earlier in the course of Multiple Sclerosis (MS) and causes great impact on patients´ quality of life. CI correlates with damage of cortical and subcortical cerebral structures. For instance, the atrophy of Corpus Callosum (CC) seems to contribute to cognitive dysfunction in MS. Generaly, both CI identification and volumetry of brain structures requires sophisticated techniques that are often inaccessible in clinical practice. The Corpus Callosum Index (CCI) has been suggested as a marker of atrophy and does not require the use of any advanced software. The BICAMS (Brief International Cognitive Assessment for Multiple Sclerosis) is a battery of Neuropsychological Tests (NTs), which includes the SDMT, CVLT-II and BVMT-R, that has been recently proposed as a quick and easy-to-use screening instrument. We have studied the association between these tools, considered ideal for daily clinical practice.
Objective: To investigate the correlation between the CC atrophy, evaluated by CCI, and the BICAMS in patients with MS.
Methods: Thirty patients with relapsing-remitting MS were included. The BICAMS was applied to these and the CCI were measured in a follow-up routine MRI. The CCI and BICAMS were also estimated in sixty healthy controls. The Correlation Coefficients (r) between NTs and CCIs, and their respective effect sizes (d), were calculated. All participants signed an Informed Consent Form.
Results: There was a significant correlation between SDMT and CCI (r = 0.41, p < 0.025, d = 0.57). BICAMS detected CI in 60% of MS patients with low CCI. When CCI shows no atrophy, 82% of patients present normal NTs.
Conclusions: The consistent association between SDMT and CCI points this index as a predictor of information processing speed impairment, oftentimes pattern of CI in MS. The cognitive dysfunctions detected by BICAMS find corresponding damage in brain structures, remarkably the CC atrophy.
Disclosure:
Marco Aurélio Gralha de Caneda: nothing to disclose
Maria Gabriela Longo: nothing to disclose
Maria Cecília Aragon de Vecino: nothing to disclose
Abstract: EP1412
Type: ePoster
Abstract Category: Clinical aspects of MS - 8 Clinical assessment tools
Background: Cognitive Impairment (CI) raises concerns since earlier in the course of Multiple Sclerosis (MS) and causes great impact on patients´ quality of life. CI correlates with damage of cortical and subcortical cerebral structures. For instance, the atrophy of Corpus Callosum (CC) seems to contribute to cognitive dysfunction in MS. Generaly, both CI identification and volumetry of brain structures requires sophisticated techniques that are often inaccessible in clinical practice. The Corpus Callosum Index (CCI) has been suggested as a marker of atrophy and does not require the use of any advanced software. The BICAMS (Brief International Cognitive Assessment for Multiple Sclerosis) is a battery of Neuropsychological Tests (NTs), which includes the SDMT, CVLT-II and BVMT-R, that has been recently proposed as a quick and easy-to-use screening instrument. We have studied the association between these tools, considered ideal for daily clinical practice.
Objective: To investigate the correlation between the CC atrophy, evaluated by CCI, and the BICAMS in patients with MS.
Methods: Thirty patients with relapsing-remitting MS were included. The BICAMS was applied to these and the CCI were measured in a follow-up routine MRI. The CCI and BICAMS were also estimated in sixty healthy controls. The Correlation Coefficients (r) between NTs and CCIs, and their respective effect sizes (d), were calculated. All participants signed an Informed Consent Form.
Results: There was a significant correlation between SDMT and CCI (r = 0.41, p < 0.025, d = 0.57). BICAMS detected CI in 60% of MS patients with low CCI. When CCI shows no atrophy, 82% of patients present normal NTs.
Conclusions: The consistent association between SDMT and CCI points this index as a predictor of information processing speed impairment, oftentimes pattern of CI in MS. The cognitive dysfunctions detected by BICAMS find corresponding damage in brain structures, remarkably the CC atrophy.
Disclosure:
Marco Aurélio Gralha de Caneda: nothing to disclose
Maria Gabriela Longo: nothing to disclose
Maria Cecília Aragon de Vecino: nothing to disclose