Contributions
Abstract: EP1408
Type: ePoster
Abstract Category: Clinical aspects of MS - 8 Clinical assessment tools
Background: Measuring whole brain atrophy has become a topic of interest in the clinical assessment of multiple sclerosis (MS). Conventional magnetic resonance imaging (MRI) in the real clinical setting may suggest the degree of cross-sectional whole brain atrophy. The generalized Pasquier scale (four-step) is simple, and is one of the main visual brain atrophy scales used for neurorradiologists in order to give a semi-quantitative insight on the axonal degeneration in MS patients.
Goal: In this study we aim to assess the correlations between the generalized Pasquier scale and quantitative automated MRI volumetric measures.
Method: Thirty-seven patients with MS were recruited from the MS Clinic at the Hospital Clínico de la Universidad de Chie (recurring-remitting MS 78%, clinically isolated syndrome 22%). They were assessed by conventional MRI imaging; semi-quantitative whole brain atrophy assessment was performed by two neurorradiologists using the generalized Pasquier scale. Cross-sectional Structural Imaging Evaluation with Normalization of Atrophy (SIENAX) analysis was performed in order to assess the global brain volume, and its partitions of grey matter - matter, peripheral gray mater and ventricular volume.
Results: The mean age was 32.4 years (range 18-52), 70% female, disease duration 1.7 years (0.7 -7), baseline Kurtzke EDSS 1.4 (0-4). There was 10.8% of patients without cortical atrophy according to generalized Pasquier scale, mild atrophy 51.4%, moderate 35.1% and severe 2.7%. These categories correlated positively well with the ventricular volume (r: 0.74; p< 0.001), and negatively well with the whole brain volume (r: -0.51, p=0.001), peripheral grey matter volume
(r: -0.45, p=0.005), white matter volume (r: -0.47, p=0.003), and the total grey matter volume (r: -0.42, p=0.009).
Conclusion: These results suggest that a semi-quantitative assesment using a visual rating of brain atrophy scale correlates well with the automated volumes that SIENAX provides. This may be useful when assesing the baseline profiles in MS patients in the real clinical practice in order to select the first disease-modifying agent.
Disclosure: nothing to disclose
Abstract: EP1408
Type: ePoster
Abstract Category: Clinical aspects of MS - 8 Clinical assessment tools
Background: Measuring whole brain atrophy has become a topic of interest in the clinical assessment of multiple sclerosis (MS). Conventional magnetic resonance imaging (MRI) in the real clinical setting may suggest the degree of cross-sectional whole brain atrophy. The generalized Pasquier scale (four-step) is simple, and is one of the main visual brain atrophy scales used for neurorradiologists in order to give a semi-quantitative insight on the axonal degeneration in MS patients.
Goal: In this study we aim to assess the correlations between the generalized Pasquier scale and quantitative automated MRI volumetric measures.
Method: Thirty-seven patients with MS were recruited from the MS Clinic at the Hospital Clínico de la Universidad de Chie (recurring-remitting MS 78%, clinically isolated syndrome 22%). They were assessed by conventional MRI imaging; semi-quantitative whole brain atrophy assessment was performed by two neurorradiologists using the generalized Pasquier scale. Cross-sectional Structural Imaging Evaluation with Normalization of Atrophy (SIENAX) analysis was performed in order to assess the global brain volume, and its partitions of grey matter - matter, peripheral gray mater and ventricular volume.
Results: The mean age was 32.4 years (range 18-52), 70% female, disease duration 1.7 years (0.7 -7), baseline Kurtzke EDSS 1.4 (0-4). There was 10.8% of patients without cortical atrophy according to generalized Pasquier scale, mild atrophy 51.4%, moderate 35.1% and severe 2.7%. These categories correlated positively well with the ventricular volume (r: 0.74; p< 0.001), and negatively well with the whole brain volume (r: -0.51, p=0.001), peripheral grey matter volume
(r: -0.45, p=0.005), white matter volume (r: -0.47, p=0.003), and the total grey matter volume (r: -0.42, p=0.009).
Conclusion: These results suggest that a semi-quantitative assesment using a visual rating of brain atrophy scale correlates well with the automated volumes that SIENAX provides. This may be useful when assesing the baseline profiles in MS patients in the real clinical practice in order to select the first disease-modifying agent.
Disclosure: nothing to disclose