Contributions
Abstract: EP1398
Type: ePoster
Abstract Category: Clinical aspects of MS - 8 Clinical assessment tools
Background: Little is known regarding the applicability of smartphone technology to promote clinical care of patients with Multiple Sclerosis (PwMS).
Aim: To assess the usefulness of a smartphone-based e-diary to the estimation of adherence to disease modifying drugs (DMDs), as well as to the collection of patient-reported outcomes (PROs).
Methods: Patients downloaded a MS tailored e-diary into their personal smartphones. The application prompted patients to take their DMDs and recorded their adherence. Report of PROs was conveyed once monthly through the application, using previously validated tools (Multiple Sclerosis Quality of Life inventory, Neuro-QoL short forms and CNS lability scale). Adherence data from the e-diary was compared to medication pack collection. PROs gathered by the e-diary were compared to corresponding functional system scores, determined by neurologic examination, as well as to patients´ subjective reports during routine follow up visits, as documented in their electronic medical record (EMR).
Results: Data from 83 PwMS was used in this analysis [Female: 54 (65%), EDSS 3.4±2.1]. Patients were using the e-diary for a median duration of 17 weeks [range:4-29 weeks]. Only 7 patients (8%) dropped out and another 3 (3%) did not agree to participate in PRO survey but continued to report their medication intake. Adherence to DMDs as reported in the e-diary was 87.1±17.8% compared to 84 ±19.2% according to pack collection. E-diary derived PROs were significantly correlated with the corresponding functional system scores (0.46< r < 0.8, P< 0.0001). The E-diary captured more MS related symptoms than documented in the EMR (e-diary compared to EMR: poor sleep 49% vs. 5%, pseudobulbar affect 17% vs 3%, upper limb dysfunction 10% vs 3% of participants). In patients with a relapse we noted increased PRO scores, which decreased following remission.
Conclusion: Smartphone-based e-diary seems suitable for PwMS and can provide useful information regarding PROs and adherence to DMDs.
Disclosure: Funding for this research was provided by Teva Pharmaceutical Industries Ltd as part of the Israeli National Network of Excellence in Neuroscience (NNE)
All authors have nothing to disclose.
Abstract: EP1398
Type: ePoster
Abstract Category: Clinical aspects of MS - 8 Clinical assessment tools
Background: Little is known regarding the applicability of smartphone technology to promote clinical care of patients with Multiple Sclerosis (PwMS).
Aim: To assess the usefulness of a smartphone-based e-diary to the estimation of adherence to disease modifying drugs (DMDs), as well as to the collection of patient-reported outcomes (PROs).
Methods: Patients downloaded a MS tailored e-diary into their personal smartphones. The application prompted patients to take their DMDs and recorded their adherence. Report of PROs was conveyed once monthly through the application, using previously validated tools (Multiple Sclerosis Quality of Life inventory, Neuro-QoL short forms and CNS lability scale). Adherence data from the e-diary was compared to medication pack collection. PROs gathered by the e-diary were compared to corresponding functional system scores, determined by neurologic examination, as well as to patients´ subjective reports during routine follow up visits, as documented in their electronic medical record (EMR).
Results: Data from 83 PwMS was used in this analysis [Female: 54 (65%), EDSS 3.4±2.1]. Patients were using the e-diary for a median duration of 17 weeks [range:4-29 weeks]. Only 7 patients (8%) dropped out and another 3 (3%) did not agree to participate in PRO survey but continued to report their medication intake. Adherence to DMDs as reported in the e-diary was 87.1±17.8% compared to 84 ±19.2% according to pack collection. E-diary derived PROs were significantly correlated with the corresponding functional system scores (0.46< r < 0.8, P< 0.0001). The E-diary captured more MS related symptoms than documented in the EMR (e-diary compared to EMR: poor sleep 49% vs. 5%, pseudobulbar affect 17% vs 3%, upper limb dysfunction 10% vs 3% of participants). In patients with a relapse we noted increased PRO scores, which decreased following remission.
Conclusion: Smartphone-based e-diary seems suitable for PwMS and can provide useful information regarding PROs and adherence to DMDs.
Disclosure: Funding for this research was provided by Teva Pharmaceutical Industries Ltd as part of the Israeli National Network of Excellence in Neuroscience (NNE)
All authors have nothing to disclose.