Contributions
Abstract: EP1391
Type: ePoster
Abstract Category: Clinical aspects of MS - 7 MS symptoms
Introduction: Vitamin D deficiency is currently regarded as a potential environmental risk factor for multiple sclerosis (MS) but the clear relationship between low vitamin D levels and disease manifestations and severity is not certainly established.
Aim: We performed a cross-sectional study aimed to investigate the relationship between vitamin D status, depression and self-reported impact of disease in patients with MS.
Methods: 106 patients treated with immunomodulatory drugs in the MS center of our hospital were included. Depression was assessed with the Beck Depression Inventory for Primary Care and patient-reported impact of MS was assessed with the Multiple Sclerosis Impact Scale (MSIS-29v2). Serum 25-hydroxyvitamin D levels were measured by chemiluminescence immunoassay method and 30 nanograms/milliliter was considered the cut-off point for deficiency.
Results: Mean age of the patients was 38.7+/- 10.1 years, with a female/male ratio of 2.1/1. Median EDSS score was 2 points (25-75 IQR 1.5-2.5). Mean serum 25-hydroxyvitamin D level was 23.2 +/- 11.8 nanograms/milliliter and 86 patients (81.1%) had low vitamin D levels. Median MSIS-29v2 - PHYS scores were 21 points (25-75 IQR 20.5-27) in patients with normal vitamin D levels and 32 points (25-75 IQR 24-48) in patients with vitamin D deficiency (p=0.0002). Median MSIS-29v2 - PSYCH scores were 13.5 points (25-75 IQR 10-17.5) in patients with normal vitamin D levels and 18 points (25-75 IQR 13-24) in patients with vitamin D deficiency (p=0.009). Depression was diagnosed in 10% of the patients with normal vitamin D levels and 19.7% of the ones with vitamin D deficiency (p=0.5).
Conclusions: We found no significant association between low vitamin D levels and depression but the physical and psychological patient-based outcome measures of the impact of multiple sclerosis were significantly worse in patients with vitamin D deficiency.
Disclosure:
Cristina Tiu: Nothing to disclose
Elena Oana Terecoasă: Nothing to disclose
Vlad Eugen Tiu: Nothing to disclose
Adriana Grigore: Nothing to disclose
Carmen Găvan: Nothing to disclose
Ovidiu Alexandru Băjenaru: Nothing to disclose
The study was supported by an unrestricted grant provided by The Foundation of The Romanian Society of Neurology
Abstract: EP1391
Type: ePoster
Abstract Category: Clinical aspects of MS - 7 MS symptoms
Introduction: Vitamin D deficiency is currently regarded as a potential environmental risk factor for multiple sclerosis (MS) but the clear relationship between low vitamin D levels and disease manifestations and severity is not certainly established.
Aim: We performed a cross-sectional study aimed to investigate the relationship between vitamin D status, depression and self-reported impact of disease in patients with MS.
Methods: 106 patients treated with immunomodulatory drugs in the MS center of our hospital were included. Depression was assessed with the Beck Depression Inventory for Primary Care and patient-reported impact of MS was assessed with the Multiple Sclerosis Impact Scale (MSIS-29v2). Serum 25-hydroxyvitamin D levels were measured by chemiluminescence immunoassay method and 30 nanograms/milliliter was considered the cut-off point for deficiency.
Results: Mean age of the patients was 38.7+/- 10.1 years, with a female/male ratio of 2.1/1. Median EDSS score was 2 points (25-75 IQR 1.5-2.5). Mean serum 25-hydroxyvitamin D level was 23.2 +/- 11.8 nanograms/milliliter and 86 patients (81.1%) had low vitamin D levels. Median MSIS-29v2 - PHYS scores were 21 points (25-75 IQR 20.5-27) in patients with normal vitamin D levels and 32 points (25-75 IQR 24-48) in patients with vitamin D deficiency (p=0.0002). Median MSIS-29v2 - PSYCH scores were 13.5 points (25-75 IQR 10-17.5) in patients with normal vitamin D levels and 18 points (25-75 IQR 13-24) in patients with vitamin D deficiency (p=0.009). Depression was diagnosed in 10% of the patients with normal vitamin D levels and 19.7% of the ones with vitamin D deficiency (p=0.5).
Conclusions: We found no significant association between low vitamin D levels and depression but the physical and psychological patient-based outcome measures of the impact of multiple sclerosis were significantly worse in patients with vitamin D deficiency.
Disclosure:
Cristina Tiu: Nothing to disclose
Elena Oana Terecoasă: Nothing to disclose
Vlad Eugen Tiu: Nothing to disclose
Adriana Grigore: Nothing to disclose
Carmen Găvan: Nothing to disclose
Ovidiu Alexandru Băjenaru: Nothing to disclose
The study was supported by an unrestricted grant provided by The Foundation of The Romanian Society of Neurology