Contributions
Abstract: EP1390
Type: ePoster
Abstract Category: Clinical aspects of MS - 7 MS symptoms
Introduction: In according to classical viewpoint epilepsy in MS is thought to be neither frequent, nor typical clinical manifestation. Precise mechanisms of epileptic seizures in MS patients and their relation to disease are still poor understood.
Aims: to investigate clinical phenotype of epileptic seizures in MS and to evaluate their relations to MS characteristics, EEG and MRI abnormalities.
Patients and methods: Among 1850 patients from local MS registry of Tatarstan Republic epileptic seizures were noted in 48. All patients with epileptic seizures besides clinical neurological evaluation undergo routine EEG (NeuroSoft) and MRI (Siemens, 3T; besides routine, double inversion recovery (DIR) sequences was performed for better cortical lesions visualization).
Main results: The prevalence of epilepsy among patients with MS in Tatarstan Republic was 2,59% (48/1850). The most frequent seizure types were partial (33%) and secondary generalized (71%). In most (90%) cases epileptic focus was clinically located in frontal or temporal lobes. Among rare variants 1 case of Kojevnikovs epilepsy, and 2 cases of epileptic cortical myoclonus were noted. In all cases epilepsy was associated with relapsing remitting (52%) or secondary progressive (48%) MS. Notably, epilepsy was also associated with more rapid MS progression: median MS severity scale (MSSS) score was 5,88 vs. 5,24 in total MS population. In 19% of cases seizures occurred before diagnosis MS, in 29% they were associated with MS relapses, in 52% such association was not observed. Regional and generalized epileptiform discharges on EEG were noted in 48 and 10% respectively. Correlation of seizure pattern, epileptiform discharges and lesions on MRI was noted in 27% cases, but with DIR sequence such correlation became higher - up to 50%. Antiepileptic therapy was completely successful in only 73% of cases.
Conclusions: Typically epilepsy in MS is presented with partial and secondary generalized seizures from frontal and temporal lobes, and associated with poor prognosis and unsatisfied treatment response.
Disclosure: Timur Khaibullin: nothing to disclosure
Farit Khabirov: nothing to disclosure
Liudmila Averianova: nothing to disclosure
Evgenii Granatov: nothing to disclosure
Natalya Babicheva: nothing to disclosure
Sofia Shakirzianova: nothing to disclosure
Abstract: EP1390
Type: ePoster
Abstract Category: Clinical aspects of MS - 7 MS symptoms
Introduction: In according to classical viewpoint epilepsy in MS is thought to be neither frequent, nor typical clinical manifestation. Precise mechanisms of epileptic seizures in MS patients and their relation to disease are still poor understood.
Aims: to investigate clinical phenotype of epileptic seizures in MS and to evaluate their relations to MS characteristics, EEG and MRI abnormalities.
Patients and methods: Among 1850 patients from local MS registry of Tatarstan Republic epileptic seizures were noted in 48. All patients with epileptic seizures besides clinical neurological evaluation undergo routine EEG (NeuroSoft) and MRI (Siemens, 3T; besides routine, double inversion recovery (DIR) sequences was performed for better cortical lesions visualization).
Main results: The prevalence of epilepsy among patients with MS in Tatarstan Republic was 2,59% (48/1850). The most frequent seizure types were partial (33%) and secondary generalized (71%). In most (90%) cases epileptic focus was clinically located in frontal or temporal lobes. Among rare variants 1 case of Kojevnikovs epilepsy, and 2 cases of epileptic cortical myoclonus were noted. In all cases epilepsy was associated with relapsing remitting (52%) or secondary progressive (48%) MS. Notably, epilepsy was also associated with more rapid MS progression: median MS severity scale (MSSS) score was 5,88 vs. 5,24 in total MS population. In 19% of cases seizures occurred before diagnosis MS, in 29% they were associated with MS relapses, in 52% such association was not observed. Regional and generalized epileptiform discharges on EEG were noted in 48 and 10% respectively. Correlation of seizure pattern, epileptiform discharges and lesions on MRI was noted in 27% cases, but with DIR sequence such correlation became higher - up to 50%. Antiepileptic therapy was completely successful in only 73% of cases.
Conclusions: Typically epilepsy in MS is presented with partial and secondary generalized seizures from frontal and temporal lobes, and associated with poor prognosis and unsatisfied treatment response.
Disclosure: Timur Khaibullin: nothing to disclosure
Farit Khabirov: nothing to disclosure
Liudmila Averianova: nothing to disclosure
Evgenii Granatov: nothing to disclosure
Natalya Babicheva: nothing to disclosure
Sofia Shakirzianova: nothing to disclosure