Contributions
Abstract: EP1379
Type: ePoster
Abstract Category: Clinical aspects of MS - 7 MS symptoms
Background: There is increasing evidence that environmental factors play a role in the development and may be progression of multiple sclerosis (MS).
Objectives: To assess MS severity and progression in MS Egyptian patients who have been residing in Gulf area in their early life.
Patients and methods: The study design was retrospective case-control approved by the Review Board of Neurology Department, Cairo University. The medical records of 21 patients with relapsing remitting MS (RRMS) in a tertiary referral center in Cairo were reviewed. Those patients were residing in Gulf in their early life (15 patients were born in Gulf and stayed till adolescence and 6 started living there since their early childhood and settled for at least 10 years) (group 1). The clinical and radiological parameters of these patients were compared with age and gender matched 21 RRMS patients who lived their entire life in Egypt (group 2).
Results: There were no significant differences between the two groups regarding age of disease onset, time from onset to diagnosis, or from diagnosis to treatment. The most frequent presenting symptom was motor dysfunction in group 1 (38.09%); and optic neuritis (ON) in group 2 (33.33%). The median Expanded Disability Status Scale (EDSS) was significantly higher in group 1 than in group 2
(5 vs. 3.5; P 0.03). Median durations from disease onset to EDSS of 4 and 6 were significantly shorter in group 1 compared with group 2 (3 and 6.5 years vs. 5.5 and 8 years; P 0.02 and 0.001 respectively). Number of infra-tentorial lesions was higher in group 1 (P 0.04); otherwise no differences in the number of black holes, supratentorial lesion load or contrast enhancement on initial MRI brain between both groups.
Conclusions: More rapid progression of MS course is observed among Egyptian RRMS patients who had their early life in Gulf, which points to a possible role of environmental factors characteristic of Gulf region in disease severity and progression.
Disclosure:
Sherif Hamdy. Nothing to disclose
Maged Abdel-Naseer. Nothing to disclose
Hatem Shehata. Nothing to disclose
Alaa Elmazny. Nothing to disclose
Amr Hassan. Nothing to disclose
Nevin Shalaby. Nothing to disclose
Abstract: EP1379
Type: ePoster
Abstract Category: Clinical aspects of MS - 7 MS symptoms
Background: There is increasing evidence that environmental factors play a role in the development and may be progression of multiple sclerosis (MS).
Objectives: To assess MS severity and progression in MS Egyptian patients who have been residing in Gulf area in their early life.
Patients and methods: The study design was retrospective case-control approved by the Review Board of Neurology Department, Cairo University. The medical records of 21 patients with relapsing remitting MS (RRMS) in a tertiary referral center in Cairo were reviewed. Those patients were residing in Gulf in their early life (15 patients were born in Gulf and stayed till adolescence and 6 started living there since their early childhood and settled for at least 10 years) (group 1). The clinical and radiological parameters of these patients were compared with age and gender matched 21 RRMS patients who lived their entire life in Egypt (group 2).
Results: There were no significant differences between the two groups regarding age of disease onset, time from onset to diagnosis, or from diagnosis to treatment. The most frequent presenting symptom was motor dysfunction in group 1 (38.09%); and optic neuritis (ON) in group 2 (33.33%). The median Expanded Disability Status Scale (EDSS) was significantly higher in group 1 than in group 2
(5 vs. 3.5; P 0.03). Median durations from disease onset to EDSS of 4 and 6 were significantly shorter in group 1 compared with group 2 (3 and 6.5 years vs. 5.5 and 8 years; P 0.02 and 0.001 respectively). Number of infra-tentorial lesions was higher in group 1 (P 0.04); otherwise no differences in the number of black holes, supratentorial lesion load or contrast enhancement on initial MRI brain between both groups.
Conclusions: More rapid progression of MS course is observed among Egyptian RRMS patients who had their early life in Gulf, which points to a possible role of environmental factors characteristic of Gulf region in disease severity and progression.
Disclosure:
Sherif Hamdy. Nothing to disclose
Maged Abdel-Naseer. Nothing to disclose
Hatem Shehata. Nothing to disclose
Alaa Elmazny. Nothing to disclose
Amr Hassan. Nothing to disclose
Nevin Shalaby. Nothing to disclose