Contributions
Abstract: EP1375
Type: ePoster
Abstract Category: Clinical aspects of MS - 7 MS symptoms
Multiple sclerosis (MS) is the most common cause of non-traumatic neurological disability affecting mainly young adults during their best working years. For the past couple of decades fatigue as well as neuropsychological deficits have been recognized to be crucial symptoms in majority of the patients. It seems that majority of the patients are unable to retain employment long term and retire soon after the diagnosis is made. We have previously reported the median time for the disability pension to be 6 years. Therefore, we aimed to evaluate the role of cognitive impairment and fatigue in the risk of early retirement due to MS in a community dwelling MS cohort.
Patients diagnosed with MS between 2000 and 2016 where collected from the electronic patient records. The retention rate of retirement was evaluated by Kapplan Maier method. The presence of fatigue was collected from the patient files and the presence of cognitive impairment from the neuropsychological assessments. Both results were analysed by the Cox proportional hazard regression analysis.
Altogether 260 patients were identified (63 males and 197 females). 56/260(21.5%) patients were retired by the time of the analysis and 66/260(25.3%) patients had gone through a neuropsychological assessment. 115/260(44.2%) patients suffered from fatigue and 59/260(22.7%) patients from other neuropsychological symptoms. Fatigue was a risk factor for the retirement (age adjusted HR 2.78 (95% CI 1.59-4.34)) but the presence of cognitive dysfunction or deficit in any of the domains in neuropsychological testing showed no statistical significance (age adjusted HR 1.22 (95% CI 0.73-2.1).
Fatigue in patients with MS is a major risk factors for early retirement. There is a clear unmet need to find effective therapies for fatigue to prevent early retirement. We did not find the presence of neuropsychological deficits to be an independent risk factor for early retirement due to MS. This might be due to the previously found correlation to the EDSS and disease duration.
Disclosure:
Tommi Heinonen: nothing to disclose
Kati Mäkinen: nothing to disclose
Elina Castren: nothing to disclose
Päivi Hämäläinen: consultation fees and travel grants (Teva, Merck, Biogen, Genzyme, Novartis, Roche)
Hanna Kuusisto: consultation fees and travel grants (Teva, Merck, Biogen, Genzyme, Novartis, Roche)
Abstract: EP1375
Type: ePoster
Abstract Category: Clinical aspects of MS - 7 MS symptoms
Multiple sclerosis (MS) is the most common cause of non-traumatic neurological disability affecting mainly young adults during their best working years. For the past couple of decades fatigue as well as neuropsychological deficits have been recognized to be crucial symptoms in majority of the patients. It seems that majority of the patients are unable to retain employment long term and retire soon after the diagnosis is made. We have previously reported the median time for the disability pension to be 6 years. Therefore, we aimed to evaluate the role of cognitive impairment and fatigue in the risk of early retirement due to MS in a community dwelling MS cohort.
Patients diagnosed with MS between 2000 and 2016 where collected from the electronic patient records. The retention rate of retirement was evaluated by Kapplan Maier method. The presence of fatigue was collected from the patient files and the presence of cognitive impairment from the neuropsychological assessments. Both results were analysed by the Cox proportional hazard regression analysis.
Altogether 260 patients were identified (63 males and 197 females). 56/260(21.5%) patients were retired by the time of the analysis and 66/260(25.3%) patients had gone through a neuropsychological assessment. 115/260(44.2%) patients suffered from fatigue and 59/260(22.7%) patients from other neuropsychological symptoms. Fatigue was a risk factor for the retirement (age adjusted HR 2.78 (95% CI 1.59-4.34)) but the presence of cognitive dysfunction or deficit in any of the domains in neuropsychological testing showed no statistical significance (age adjusted HR 1.22 (95% CI 0.73-2.1).
Fatigue in patients with MS is a major risk factors for early retirement. There is a clear unmet need to find effective therapies for fatigue to prevent early retirement. We did not find the presence of neuropsychological deficits to be an independent risk factor for early retirement due to MS. This might be due to the previously found correlation to the EDSS and disease duration.
Disclosure:
Tommi Heinonen: nothing to disclose
Kati Mäkinen: nothing to disclose
Elina Castren: nothing to disclose
Päivi Hämäläinen: consultation fees and travel grants (Teva, Merck, Biogen, Genzyme, Novartis, Roche)
Hanna Kuusisto: consultation fees and travel grants (Teva, Merck, Biogen, Genzyme, Novartis, Roche)