Contributions
Abstract: EP1370
Type: ePoster
Abstract Category: Clinical aspects of MS - 7 MS symptoms
Introduction: Recent studies propose that patients with Multiple Sclerosis (MS) are at increased risk for sleep disturbances and they are undiagnosed. Fatigue is perceived as one of the most disabling symptoms in MS. The relation between fatigue and sleep disturbances is a subject of study due to it is not yet fully understood.
The primary endpoint of this study is to analyze the prevalence of sleep disorders in a cohort of adult patients with MS evaluating the link between these disorders and their clinical features (type of MS, disease duration, clinical severity, presence of spinal demyelinating lesions and presence or absence of Interferon).
The other main objective is to evaluate the relations between sleep disturbances and fatigue of the MS patients enrolled in the study.
Methods: Fifty-nine patients with MS took part in this cross-sectional study. Participants completed standardized validated questionnaires related fatigue (Modified Fatigue Impact Scale-MFIS) and sleep disturbances (Insomnia Severity Index-ISI, STOP-BANG questionnaire, Pittsburgh Sleep Quality Index -PSQI and patients who meet International Restless Legs Syndrome Study Group criteria for the diagnosis of Restless Legs Syndrome completed Restless Legs Syndrome Rating Scale-RLS).
Results: As concerns sleep evaluation, 35.6% patients suggesting RLS, 54.2% have insomnia (ISI score>5), 10.2% have a high or medium risk of Sleep Apnea Syndrome (SAS) according to the STOP-BANG questionnaire and 35.6% patients were considered fatigued (MFIS>45).
Statistical analysis showed that clinical findings are not associated whit sleep quality and sleep disturbances; except high risk of OSAS which was associated with disease duration (U-test=77.500; p=0.041).
Patients with fatigue show higher prevalence of poor sleep quality (p=0.012) and sleepiness (p=0.001) whit higher PSQI scores (U-test=225.000; p=0.006) and sleepiness score (U-test=201.000; p=0.001). They have higher prevalence of RLS (p=0.022), insomnia (p=0.000), and OSAS (p=0.018), with higher severity of symptom: U-test=235.500, p=0.002; U-test=170.500, p=0.000 and U-test=245.500, p=0.009 respectively.
Conclusions: The present study demonstrates the association between MS and a higher prevalence of sleep disorders. Besides, it shows the close link between insomnia, sleepiness, sleep quality, OSAS presence, RLS and fatigue. On the contrary, sleep quality and sleep disorder are not related with the analyzed clinical findings.
Disclosure:
Irene Gómez-Estévez: nothing to disclose
Yasmina El Berdei Montero: nothing to disclose
Marta Fiz Santelesforo: nothing to disclose
José C. Gómez-Sánchez: nothing to disclose
Abstract: EP1370
Type: ePoster
Abstract Category: Clinical aspects of MS - 7 MS symptoms
Introduction: Recent studies propose that patients with Multiple Sclerosis (MS) are at increased risk for sleep disturbances and they are undiagnosed. Fatigue is perceived as one of the most disabling symptoms in MS. The relation between fatigue and sleep disturbances is a subject of study due to it is not yet fully understood.
The primary endpoint of this study is to analyze the prevalence of sleep disorders in a cohort of adult patients with MS evaluating the link between these disorders and their clinical features (type of MS, disease duration, clinical severity, presence of spinal demyelinating lesions and presence or absence of Interferon).
The other main objective is to evaluate the relations between sleep disturbances and fatigue of the MS patients enrolled in the study.
Methods: Fifty-nine patients with MS took part in this cross-sectional study. Participants completed standardized validated questionnaires related fatigue (Modified Fatigue Impact Scale-MFIS) and sleep disturbances (Insomnia Severity Index-ISI, STOP-BANG questionnaire, Pittsburgh Sleep Quality Index -PSQI and patients who meet International Restless Legs Syndrome Study Group criteria for the diagnosis of Restless Legs Syndrome completed Restless Legs Syndrome Rating Scale-RLS).
Results: As concerns sleep evaluation, 35.6% patients suggesting RLS, 54.2% have insomnia (ISI score>5), 10.2% have a high or medium risk of Sleep Apnea Syndrome (SAS) according to the STOP-BANG questionnaire and 35.6% patients were considered fatigued (MFIS>45).
Statistical analysis showed that clinical findings are not associated whit sleep quality and sleep disturbances; except high risk of OSAS which was associated with disease duration (U-test=77.500; p=0.041).
Patients with fatigue show higher prevalence of poor sleep quality (p=0.012) and sleepiness (p=0.001) whit higher PSQI scores (U-test=225.000; p=0.006) and sleepiness score (U-test=201.000; p=0.001). They have higher prevalence of RLS (p=0.022), insomnia (p=0.000), and OSAS (p=0.018), with higher severity of symptom: U-test=235.500, p=0.002; U-test=170.500, p=0.000 and U-test=245.500, p=0.009 respectively.
Conclusions: The present study demonstrates the association between MS and a higher prevalence of sleep disorders. Besides, it shows the close link between insomnia, sleepiness, sleep quality, OSAS presence, RLS and fatigue. On the contrary, sleep quality and sleep disorder are not related with the analyzed clinical findings.
Disclosure:
Irene Gómez-Estévez: nothing to disclose
Yasmina El Berdei Montero: nothing to disclose
Marta Fiz Santelesforo: nothing to disclose
José C. Gómez-Sánchez: nothing to disclose