Contributions
Abstract: EP1366
Type: ePoster
Abstract Category: Clinical aspects of MS - 7 MS symptoms
Cognitive dysfunction(CD) in multiple sclerosis(MS) is one of the most disabling symptoms of the disease, affecting 30-65% of patients. Most commonly affected cognitive domains are memory, attention and processing speed. The protective effect of cognitive reserve(CR) has been demonstrated. We aim to analyze the prevalence of CD and the type of domain impairment in a Spanish MS cohort. In addition, we examine the effect of CR, mood disorders, fatigue, psychiatric drugs, demographic and clinical variables on cognitive performance(CP).
We enrolled MS patients over 24 years old diagnosed according to the McDonald Criteria 2011. We excluded patients with other neurologic diseases or conditions that may affect CP(relapses, corticoid treatment or changes in disease modifying therapies in the last 4 weeks, psychiatric disorder...).We used Rao abbreviated Neuropsychological battery to analyse the prevalence of CD; educational level, years of education, professional complexity, vocabulary knowledge and leisure activities to evaluate CR; and validated questionnaires for demographic variables, clinical forms of MS, EDSS, fatigue, anxiety and depression.
We included 62 MS patients(74.2% women) with a mean age of 39.98 years. The prevalence of cognitive dysfunction was 38.7%. Verbal memory (64.5%) and processing speed(32.2%) were the most affected domains. Educational level(p=0.014), years of education(p=0.004), professional complexity(p=0.005), vocabulary knowledge(p=0.006), and leisure activities(p=0.014) were associated with a better CP in univariate analyses. Disability(p=0.045) and the usage of psychiatric drugs(p=0.002) were associated with worse CP in univariate analyses. Multivariate logistical regression model showed that low scores in leisure activities(p=0.031) and vocabulary knowledge (p=0.047) were independent variables for prediction of CD in MS.
Our results confirm a similar prevalence of CD and the type of domain impairment in a Spanish MS cohort as previously described in the literature. We also confirm a protective value of CR(measured by leisure activities and vocabulary knowledge) in the appearance of CD in MS.
Disclosure:
Cerdá Fuertes N: nothing to disclose
Díaz Sánchez M: nothing to disclose
Lebrato Hernández L: nothing to disclose
Prieto León M: nothing to disclose
Casado Chocán JL: nothing to disclose
Uclés Sánchez AJ: nothing to disclose
Abstract: EP1366
Type: ePoster
Abstract Category: Clinical aspects of MS - 7 MS symptoms
Cognitive dysfunction(CD) in multiple sclerosis(MS) is one of the most disabling symptoms of the disease, affecting 30-65% of patients. Most commonly affected cognitive domains are memory, attention and processing speed. The protective effect of cognitive reserve(CR) has been demonstrated. We aim to analyze the prevalence of CD and the type of domain impairment in a Spanish MS cohort. In addition, we examine the effect of CR, mood disorders, fatigue, psychiatric drugs, demographic and clinical variables on cognitive performance(CP).
We enrolled MS patients over 24 years old diagnosed according to the McDonald Criteria 2011. We excluded patients with other neurologic diseases or conditions that may affect CP(relapses, corticoid treatment or changes in disease modifying therapies in the last 4 weeks, psychiatric disorder...).We used Rao abbreviated Neuropsychological battery to analyse the prevalence of CD; educational level, years of education, professional complexity, vocabulary knowledge and leisure activities to evaluate CR; and validated questionnaires for demographic variables, clinical forms of MS, EDSS, fatigue, anxiety and depression.
We included 62 MS patients(74.2% women) with a mean age of 39.98 years. The prevalence of cognitive dysfunction was 38.7%. Verbal memory (64.5%) and processing speed(32.2%) were the most affected domains. Educational level(p=0.014), years of education(p=0.004), professional complexity(p=0.005), vocabulary knowledge(p=0.006), and leisure activities(p=0.014) were associated with a better CP in univariate analyses. Disability(p=0.045) and the usage of psychiatric drugs(p=0.002) were associated with worse CP in univariate analyses. Multivariate logistical regression model showed that low scores in leisure activities(p=0.031) and vocabulary knowledge (p=0.047) were independent variables for prediction of CD in MS.
Our results confirm a similar prevalence of CD and the type of domain impairment in a Spanish MS cohort as previously described in the literature. We also confirm a protective value of CR(measured by leisure activities and vocabulary knowledge) in the appearance of CD in MS.
Disclosure:
Cerdá Fuertes N: nothing to disclose
Díaz Sánchez M: nothing to disclose
Lebrato Hernández L: nothing to disclose
Prieto León M: nothing to disclose
Casado Chocán JL: nothing to disclose
Uclés Sánchez AJ: nothing to disclose