Contributions
Abstract: EP1354
Type: ePoster
Abstract Category: Clinical aspects of MS - 6 MS and gender
Introduction: Postpartum disease and MRI activation is common among MS patients. In this study we tried to investigate the relation between Gd-enhancing lesions before and after pregnancy in Iranian MS patients.
Patients and methods: During a retrospective study between 2011 to 2016, we evaluated the medical records of all women patients with MS in our MS outpatient clinic in Shiraz Southern Iran. We detected that 75 patients had history of pregnancy in this period. These patients were selected. Demographic data, clinical findings, history of relapse, brain MRI findings and Gd-enhancing lesions during one year prior to pregnancy, type of medication, time of withdrawal of medications before pregnancy in one hand and history of relapse, MRI Gd-enhancing lesions, history of lactation during 9 months after pregnancy in the other hand were collected via a questionnaire . Statistical analysis was performed under supervision of statistical specialist.
Results: Seventy five MS patients were enrolled in the study. The mean age of the patients at the onset of pregnancy was 33.2±4.5 years. 76%, 86.7% and 70.7% of the patients were relapse-free in one year duration before, during and 9 months follow up after pregnancy. After pregnancy the rate of relapse increased significantly and 29.3% of patients had at least one relapse. (P value < .001)
Presence of Gd-enhancing lesions in brain MRI during one year before pregnancy was significantly correlated with new Gd-enhancing lesions in brain MRI in 9 months follow up after pregnancy. (P value< 0.001)
Other factors such as type of medications and history of lactation did not have any significant correlation with MRI Gd-enhancing lesions or relapse after pregnancy.
Conclusion: Post-partum activation of the disease is common phenomenon among mothers with MS. In this study we showed that presence of Gd-enhancing lesions in MRI before pregnancy is correlated with MRI activity after delivery.
Keywords: Pregnancy, Multiple sclerosis, MRI, Gd-enhancing lesions
Disclosure: There is no Conflict of interest.
Abstract: EP1354
Type: ePoster
Abstract Category: Clinical aspects of MS - 6 MS and gender
Introduction: Postpartum disease and MRI activation is common among MS patients. In this study we tried to investigate the relation between Gd-enhancing lesions before and after pregnancy in Iranian MS patients.
Patients and methods: During a retrospective study between 2011 to 2016, we evaluated the medical records of all women patients with MS in our MS outpatient clinic in Shiraz Southern Iran. We detected that 75 patients had history of pregnancy in this period. These patients were selected. Demographic data, clinical findings, history of relapse, brain MRI findings and Gd-enhancing lesions during one year prior to pregnancy, type of medication, time of withdrawal of medications before pregnancy in one hand and history of relapse, MRI Gd-enhancing lesions, history of lactation during 9 months after pregnancy in the other hand were collected via a questionnaire . Statistical analysis was performed under supervision of statistical specialist.
Results: Seventy five MS patients were enrolled in the study. The mean age of the patients at the onset of pregnancy was 33.2±4.5 years. 76%, 86.7% and 70.7% of the patients were relapse-free in one year duration before, during and 9 months follow up after pregnancy. After pregnancy the rate of relapse increased significantly and 29.3% of patients had at least one relapse. (P value < .001)
Presence of Gd-enhancing lesions in brain MRI during one year before pregnancy was significantly correlated with new Gd-enhancing lesions in brain MRI in 9 months follow up after pregnancy. (P value< 0.001)
Other factors such as type of medications and history of lactation did not have any significant correlation with MRI Gd-enhancing lesions or relapse after pregnancy.
Conclusion: Post-partum activation of the disease is common phenomenon among mothers with MS. In this study we showed that presence of Gd-enhancing lesions in MRI before pregnancy is correlated with MRI activity after delivery.
Keywords: Pregnancy, Multiple sclerosis, MRI, Gd-enhancing lesions
Disclosure: There is no Conflict of interest.