Contributions
Abstract: EP1353
Type: ePoster
Abstract Category: Clinical aspects of MS - 6 MS and gender
Background: Cortical demyelination and gray matter atrophy are more prominent to occur in primary progressive multiple sclerosis (PPMS) than in relapsing-remitting multiple sclerosis (RRMS) patients. PPMS course is more common in males while RRMS course is more common in females.
Objectives: To identify the differences regarding changes in cortical grey matter thickness (CGMT) between males and females PPMS patients as compared with RRMS patients.
Methods: Cross sectional, paired study comparing brain measurements of PPMS and RRMS patients using high resolution 3D brain MRI. Patients were matched by age, gender, and disease duration. Freesurfer 5.3 software was applied to obtain whole brain volumetric segmentation of subcortical regions and cortical thickness measurements. Paired t-test was performed to assess differences between groups.
Results: Ninety two patients were included, divided into 46 pairs of PPMS and RRMS patients; 25 female pairs mean±SD age 50±12yr, range 22-65yr, disease duration 10.7±8.5yr, and 21 male pairs age 50±10yr, range 31-67yr, disease duration 10.6±9.9yr. Cortical analysis of the female pairs demonstrated an overall decreased CGMT of the left hemisphere in PPMS as compared to RRMS patients (-11.67%, p=0.032), and no significant differences in the right hemisphere. Surface based analysis revealed focal clusters of decreased CGMT in the PPMS female group in the inferior-parietal and entorhinal in the left hemisphere and precuneus, superior-frontal and pre-central gyri in the right hemispheres as compared to RRMS female patients (-11% to -15%, p< 0.03). Cortical analysis of male patients demonstrated no significant difference between the groups.
Conclusion: Gender specific patterns of CGMT differ between female PPMS and RRMS patients.
Disclosure:
K. Pardo: nothing to disclose.
Or-Bach L: nothing to disclose.
Menascu S: Consulting fees: (Genzyme); contracted research (Bayer, Biogen Idec, EMD Serono, Genzyme, Roche).
Dolev M: Consulting fees: (Genzyme); contracted research (Bayer, Biogen Idec, EMD Serono, Genzyme, Roche).
Magalashvili D: Consulting fees: (Genzyme); contracted research (Bayer, Biogen Idec, EMD Serono, Genzyme, Roche).
Achiron Anat: Consulting fees: (EMD Serono, Genzyme, Roche); contracted research (Bayer, Biogen Idec, EMD Serono, Genzyme, Roche)
Abstract: EP1353
Type: ePoster
Abstract Category: Clinical aspects of MS - 6 MS and gender
Background: Cortical demyelination and gray matter atrophy are more prominent to occur in primary progressive multiple sclerosis (PPMS) than in relapsing-remitting multiple sclerosis (RRMS) patients. PPMS course is more common in males while RRMS course is more common in females.
Objectives: To identify the differences regarding changes in cortical grey matter thickness (CGMT) between males and females PPMS patients as compared with RRMS patients.
Methods: Cross sectional, paired study comparing brain measurements of PPMS and RRMS patients using high resolution 3D brain MRI. Patients were matched by age, gender, and disease duration. Freesurfer 5.3 software was applied to obtain whole brain volumetric segmentation of subcortical regions and cortical thickness measurements. Paired t-test was performed to assess differences between groups.
Results: Ninety two patients were included, divided into 46 pairs of PPMS and RRMS patients; 25 female pairs mean±SD age 50±12yr, range 22-65yr, disease duration 10.7±8.5yr, and 21 male pairs age 50±10yr, range 31-67yr, disease duration 10.6±9.9yr. Cortical analysis of the female pairs demonstrated an overall decreased CGMT of the left hemisphere in PPMS as compared to RRMS patients (-11.67%, p=0.032), and no significant differences in the right hemisphere. Surface based analysis revealed focal clusters of decreased CGMT in the PPMS female group in the inferior-parietal and entorhinal in the left hemisphere and precuneus, superior-frontal and pre-central gyri in the right hemispheres as compared to RRMS female patients (-11% to -15%, p< 0.03). Cortical analysis of male patients demonstrated no significant difference between the groups.
Conclusion: Gender specific patterns of CGMT differ between female PPMS and RRMS patients.
Disclosure:
K. Pardo: nothing to disclose.
Or-Bach L: nothing to disclose.
Menascu S: Consulting fees: (Genzyme); contracted research (Bayer, Biogen Idec, EMD Serono, Genzyme, Roche).
Dolev M: Consulting fees: (Genzyme); contracted research (Bayer, Biogen Idec, EMD Serono, Genzyme, Roche).
Magalashvili D: Consulting fees: (Genzyme); contracted research (Bayer, Biogen Idec, EMD Serono, Genzyme, Roche).
Achiron Anat: Consulting fees: (EMD Serono, Genzyme, Roche); contracted research (Bayer, Biogen Idec, EMD Serono, Genzyme, Roche)