Contributions
Abstract: EP1352
Type: ePoster
Abstract Category: Clinical aspects of MS - 5 Epidemiology
Introduction: Multiple sclerosis (MS) is known to accumulate within families. It's a complexe neurological disorder resulting from an interaction between environnemental and genetic risk factor 0A lot of loci have been identified that playing arole in MS disease suceptibility Although most MS cases occur sporadically,. While this accumulation of cases clearly suggests that first-degree relatives of MS patients are at increased risk of MS, previous attempts to assess the magnitude of the familial MS risk have arrived at variable estimates.
Aims: To report the frequency of familial MS .To compare the demographic and clinical characteristics between those with and without a positive family history of MS .Evaluate the prognosis
Patients and methods: All patients with MS are included in the study, the diagnosis is made according to the McDonald 2010 criteria. The family history of MS is obtained by the interview, demographic data including information on immediate family member and degree of relationship. clinical information was sourced By neurological examination. The disability was appreciated by the EDSS .
Results: 450 MS patients were monitored at the Tlemcen University Hospital Neurology Department in 2017, 57 of them had a family history of MS. The prevalence of MS was 12.6%. They reported at least one first-degree relative . There was no significant demographic and clinical difference between FMS compared to the non-familial form. In 36% EDSS Iis greater than 6. 12% died 25-50 years. The familial form of MS is more severe, EDSS 6 is reached more rapidly than NSE.
Conclusion: The evolution is more severe in the familial form probably of the genetic context with the Maghrebian profile considered as severe
Disclosure: No conflit of interest
Abstract: EP1352
Type: ePoster
Abstract Category: Clinical aspects of MS - 5 Epidemiology
Introduction: Multiple sclerosis (MS) is known to accumulate within families. It's a complexe neurological disorder resulting from an interaction between environnemental and genetic risk factor 0A lot of loci have been identified that playing arole in MS disease suceptibility Although most MS cases occur sporadically,. While this accumulation of cases clearly suggests that first-degree relatives of MS patients are at increased risk of MS, previous attempts to assess the magnitude of the familial MS risk have arrived at variable estimates.
Aims: To report the frequency of familial MS .To compare the demographic and clinical characteristics between those with and without a positive family history of MS .Evaluate the prognosis
Patients and methods: All patients with MS are included in the study, the diagnosis is made according to the McDonald 2010 criteria. The family history of MS is obtained by the interview, demographic data including information on immediate family member and degree of relationship. clinical information was sourced By neurological examination. The disability was appreciated by the EDSS .
Results: 450 MS patients were monitored at the Tlemcen University Hospital Neurology Department in 2017, 57 of them had a family history of MS. The prevalence of MS was 12.6%. They reported at least one first-degree relative . There was no significant demographic and clinical difference between FMS compared to the non-familial form. In 36% EDSS Iis greater than 6. 12% died 25-50 years. The familial form of MS is more severe, EDSS 6 is reached more rapidly than NSE.
Conclusion: The evolution is more severe in the familial form probably of the genetic context with the Maghrebian profile considered as severe
Disclosure: No conflit of interest