Contributions
Abstract: EP1342
Type: ePoster
Abstract Category: Clinical aspects of MS - 5 Epidemiology
Introduction and objetives: Multiple sclerosis (MS) typically debut between the age of 20 and 40; however, the first symptoms can occur after age 50 and is classified as late-onset MS (LOMS). The purpose of the present study was to review the prevalence, presentation, and clinical characteristics of late-onset MS.
Methods: In this retrospective study what we include 450 patients with the diagnosis of MS established according to Poser or Mc Donald criteria, select those older than 50 years and review demographic characteristics, first onset symptom, diagnostic delay, disability at the time of diagnosis (EDSS), Progression Index (PI) disease course and findings in CSF, and MRI studies.
Results: We included 21 patients with LOMS (4,7%), of the total 450 MS patients, diagnosed between 1982 and 2016. 15 (71%) females and 6 (29%) males. Mean age at onset was 53(SD±3,4). The most frequent first symptoms were motor deficits (52%), followed by brainstem disorder (24%), and sensory deficits (10%). The clinical course was in 42% relapsing-remitting(RR), in 38% primary progressive(PP) and in 19% secondary progressive(SP). The initial EDSS score was 3,7 (SD ±1,8). The mean PI was 0, 48. The mean of diagnostic delay was 52 month. The brain MRI has ≥ nine lesions in 86%, and spine MRI has ≥ three lesions in 52%. IgG oligoclonal bands were positive in 71% of patients in the CSF study. In addition 5 out of 21 (31%) patients had suffered a major depressive episode and 44% had cognitive impairment. In six cases there was a previous wrong diagnosis, being the most frequent the spondyloartrhitic cervical myelopathy.
Conclusions: The onset of multiple sclerosis (LOMS) after age 50 is infrequent, in our series the most common type is RR but PP is more frequent than in another younger groups and motors symptoms are the most frequent initial neurological presentation.
Disclosure:
Gabriel Valero López: nothing to disclose
Ana E. Baidez Guerrero: nothing to disclose
Estefania García Molina: nothing to disclose
Ester Carreón Guarnizo: nothing to disclose
Rocio Hernández Clares: nothing to disclose
José Díaz Pérez: nothing to disclose
Luna Fuentes Rumí: nothing to disclose
José María Cabrera Maqueda: nothing to disclose
Jose E. Meca Lallana: nothing to disclose
Abstract: EP1342
Type: ePoster
Abstract Category: Clinical aspects of MS - 5 Epidemiology
Introduction and objetives: Multiple sclerosis (MS) typically debut between the age of 20 and 40; however, the first symptoms can occur after age 50 and is classified as late-onset MS (LOMS). The purpose of the present study was to review the prevalence, presentation, and clinical characteristics of late-onset MS.
Methods: In this retrospective study what we include 450 patients with the diagnosis of MS established according to Poser or Mc Donald criteria, select those older than 50 years and review demographic characteristics, first onset symptom, diagnostic delay, disability at the time of diagnosis (EDSS), Progression Index (PI) disease course and findings in CSF, and MRI studies.
Results: We included 21 patients with LOMS (4,7%), of the total 450 MS patients, diagnosed between 1982 and 2016. 15 (71%) females and 6 (29%) males. Mean age at onset was 53(SD±3,4). The most frequent first symptoms were motor deficits (52%), followed by brainstem disorder (24%), and sensory deficits (10%). The clinical course was in 42% relapsing-remitting(RR), in 38% primary progressive(PP) and in 19% secondary progressive(SP). The initial EDSS score was 3,7 (SD ±1,8). The mean PI was 0, 48. The mean of diagnostic delay was 52 month. The brain MRI has ≥ nine lesions in 86%, and spine MRI has ≥ three lesions in 52%. IgG oligoclonal bands were positive in 71% of patients in the CSF study. In addition 5 out of 21 (31%) patients had suffered a major depressive episode and 44% had cognitive impairment. In six cases there was a previous wrong diagnosis, being the most frequent the spondyloartrhitic cervical myelopathy.
Conclusions: The onset of multiple sclerosis (LOMS) after age 50 is infrequent, in our series the most common type is RR but PP is more frequent than in another younger groups and motors symptoms are the most frequent initial neurological presentation.
Disclosure:
Gabriel Valero López: nothing to disclose
Ana E. Baidez Guerrero: nothing to disclose
Estefania García Molina: nothing to disclose
Ester Carreón Guarnizo: nothing to disclose
Rocio Hernández Clares: nothing to disclose
José Díaz Pérez: nothing to disclose
Luna Fuentes Rumí: nothing to disclose
José María Cabrera Maqueda: nothing to disclose
Jose E. Meca Lallana: nothing to disclose