Contributions
Abstract: EP1338
Type: ePoster
Abstract Category: Clinical aspects of MS - 5 Epidemiology
Background: Neuromyelitys optica is an infrequent demyelinating disease and epidemiological information on NMO is rare. The aim of this study was to estimate the prevalence, clinical features and serology of NMO in Caucasian population in Tehran, Iran.
Method: A cross sectional study was performed during 2015 to 2016 in Tehran among patients registered with NMO diagnosis based on international 2015 consensus criteria in Sina hospital a tertiary care referral center in Tehran. A structured questionnaire was design in MS Research Center of Tehran university of medical sciences to measure the baseline characteristic, severity of symptoms and significant epidemiological variables which were associated for NMO.
The goals of study were described for 103 registered patients and data were collected from hospital database registry system and patient's information through face to face interview.
The logistic regression was applying in analysis by software package SPSS.
Result: The prevalence of NMO in Tehran was 0.86 per 100,000 in 2016 with point prevalence for females and males rate of 1.35 and 0.26 per 100,000 respectively.
Female to male ratio was 5:1. The mean age at the disease onset was 31.54 years old. NMO-IgG was positive in 44 (46.8%) and first presenting symptoms among patients were TM 29 (28.2%), ON in (23.3%), (17.47%) had unilateral declined visual acuity, TM + ON in (46.6%) and 2 (1.9%) of them presented NMO with other appearances. Based on our study, ON had significant association with female gender.
The adjusted odds ratio for sex was estimated for depression (OR = 6.83; 95% CI: 1.47, 31.71), migraine (OR = 1.27; 95% CI: 1.13, 1.42) and hypothyroidism (OR = 1.25; 95% CI: 1.12, 1.39).
Conclusions: We indicated that the risk of NMO is significantly higher among females and younger age group and patients who had background of depression, migraine and hypothyroidism.
Disclosure: Funding Source: This study was funded by Tehran University of medical sciences.
Conflict of Interest: Authors declare no conflict of interest.
Although this study (the largest population based study) provides important current epidemiological data and we believe that our results provide crude minimum estimate rates of prevalence then are expected to rise dramatically in future studies.The outcomes of this study examined some significant epidemiological factors and clinical features for NMO. We indicated that the risk of NMO is significantly higher among females, younger age and patients who had history of depression, migraine and hypo toroid.
Abstract: EP1338
Type: ePoster
Abstract Category: Clinical aspects of MS - 5 Epidemiology
Background: Neuromyelitys optica is an infrequent demyelinating disease and epidemiological information on NMO is rare. The aim of this study was to estimate the prevalence, clinical features and serology of NMO in Caucasian population in Tehran, Iran.
Method: A cross sectional study was performed during 2015 to 2016 in Tehran among patients registered with NMO diagnosis based on international 2015 consensus criteria in Sina hospital a tertiary care referral center in Tehran. A structured questionnaire was design in MS Research Center of Tehran university of medical sciences to measure the baseline characteristic, severity of symptoms and significant epidemiological variables which were associated for NMO.
The goals of study were described for 103 registered patients and data were collected from hospital database registry system and patient's information through face to face interview.
The logistic regression was applying in analysis by software package SPSS.
Result: The prevalence of NMO in Tehran was 0.86 per 100,000 in 2016 with point prevalence for females and males rate of 1.35 and 0.26 per 100,000 respectively.
Female to male ratio was 5:1. The mean age at the disease onset was 31.54 years old. NMO-IgG was positive in 44 (46.8%) and first presenting symptoms among patients were TM 29 (28.2%), ON in (23.3%), (17.47%) had unilateral declined visual acuity, TM + ON in (46.6%) and 2 (1.9%) of them presented NMO with other appearances. Based on our study, ON had significant association with female gender.
The adjusted odds ratio for sex was estimated for depression (OR = 6.83; 95% CI: 1.47, 31.71), migraine (OR = 1.27; 95% CI: 1.13, 1.42) and hypothyroidism (OR = 1.25; 95% CI: 1.12, 1.39).
Conclusions: We indicated that the risk of NMO is significantly higher among females and younger age group and patients who had background of depression, migraine and hypothyroidism.
Disclosure: Funding Source: This study was funded by Tehran University of medical sciences.
Conflict of Interest: Authors declare no conflict of interest.
Although this study (the largest population based study) provides important current epidemiological data and we believe that our results provide crude minimum estimate rates of prevalence then are expected to rise dramatically in future studies.The outcomes of this study examined some significant epidemiological factors and clinical features for NMO. We indicated that the risk of NMO is significantly higher among females, younger age and patients who had history of depression, migraine and hypo toroid.