Contributions
Abstract: EP1332
Type: ePoster
Abstract Category: Clinical aspects of MS - 5 Epidemiology
Background and objective: Clustering of autoimmune diseases (AIDs) has been described in individuals with multiple sclerosis (MS) and their first-degree family members. However to what extent MS and other AIDs co-occur in MS multiplex families with two or more affected individuals is still controversial. We aimed to evaluate co-existing AIDs in MS patients and their first-degree family members from the Dutch MS multiplex families and compare them to spousal controls.
Methods: A total of 155 multiplex families (155 MS probands, 789 first-degree relatives and 212 spouses) were characterized for a history of 11 AIDs by means of a self-administered questionnaire.
Results: An AID was reported in 17 (11%) MS probands. In 67 (43.2%) MS multiplex families at least one AID was present in the first-degree relatives. Overall frequency of AIDs was similar in MS probands (11%), their first-degree family members (11%) and in spousal controls (5.2%). After correction for age at inclusion and gender, the odd ratios (OR) for AIDs were not significant for MS probands compared to spouses (OR=1.8, 0.77-4.34, p=0.17), and for first-degree family members compared to spouses (OR=2.0, 0.98-4.10, p = 0.06). Frequency of AIDs in mothers of MS index cases was more than twice of that in fathers (19% vs 8%, p= 0.0052). Maternal second-degree relatives reported more often a presence of AIDs than paternal second-degree relatives (23% vs 10%, p=0.0020).
Conclusion: Although nearly half of the Dutch MS multiplex families reported an AID, no excess of AIDs was present in MS patients from multiplex families or their first degree family members compared to their spouses. Increased autoimmunity in mothers and maternal relatives of MS index cases suggest that there might be a maternal parent-of-origin effect for AID in MS patients from multiplex families.
Disclosure:
JY Mescheriakova reports no disclosures.
RQ Hintzen reports no disclosures.
Abstract: EP1332
Type: ePoster
Abstract Category: Clinical aspects of MS - 5 Epidemiology
Background and objective: Clustering of autoimmune diseases (AIDs) has been described in individuals with multiple sclerosis (MS) and their first-degree family members. However to what extent MS and other AIDs co-occur in MS multiplex families with two or more affected individuals is still controversial. We aimed to evaluate co-existing AIDs in MS patients and their first-degree family members from the Dutch MS multiplex families and compare them to spousal controls.
Methods: A total of 155 multiplex families (155 MS probands, 789 first-degree relatives and 212 spouses) were characterized for a history of 11 AIDs by means of a self-administered questionnaire.
Results: An AID was reported in 17 (11%) MS probands. In 67 (43.2%) MS multiplex families at least one AID was present in the first-degree relatives. Overall frequency of AIDs was similar in MS probands (11%), their first-degree family members (11%) and in spousal controls (5.2%). After correction for age at inclusion and gender, the odd ratios (OR) for AIDs were not significant for MS probands compared to spouses (OR=1.8, 0.77-4.34, p=0.17), and for first-degree family members compared to spouses (OR=2.0, 0.98-4.10, p = 0.06). Frequency of AIDs in mothers of MS index cases was more than twice of that in fathers (19% vs 8%, p= 0.0052). Maternal second-degree relatives reported more often a presence of AIDs than paternal second-degree relatives (23% vs 10%, p=0.0020).
Conclusion: Although nearly half of the Dutch MS multiplex families reported an AID, no excess of AIDs was present in MS patients from multiplex families or their first degree family members compared to their spouses. Increased autoimmunity in mothers and maternal relatives of MS index cases suggest that there might be a maternal parent-of-origin effect for AID in MS patients from multiplex families.
Disclosure:
JY Mescheriakova reports no disclosures.
RQ Hintzen reports no disclosures.