Contributions
Abstract: EP1303
Type: ePoster
Abstract Category: Clinical aspects of MS - 2 MS Variants
The 'atypical' myelitis of multiple sclerosis (MS), are characterised by longitudinally extensive myelitis (≥3 vertebral segments), transverse myelitis (> 50% of spinal cord in the axial plane), or pseudovascular (anterior or central) cord lesions.
This study is observational, retrospective, multicentric, and includes incident cases between 2012 and 2017. Sixteen patients were included in the University Hospital of Strasbourg, Nice, Poitiers and Montpellier in France.
We collected demographic information, clinical and radiological characteristics of myelitis, laboratory results including CSF, brain and spinal cord MRI, treatment, and clinical follow-up.
The aim of this study was to collect atypical cases of myelitis related to MS to better characterise this population.
All patients fulfilled 2010 Macdonald criteria without any other alternative diagnosis. The mean age of onset was 39,1 +/- 12,4 years, the sex ratio was 1,6 women for 1 man. The myelitis was the first relapse for 12 patients, the second for 2 patients and the third for 1 patient. The intrathecal synthesis of immunoglobulin was found in all cases. On spinal cord MRI, we observed 3 longitudinally extensive myelitis, 9 transverse myelitis, 3 transverse and longitudinally extensive myelitis and 3 patients have an association with a central cord lesion. The median EDSS was 4,75 [1-8] during the relapse, 4,5 [0-6,5] after 6 months and 3,5 [0-7] after 3,9 +/- 3,1 years of follow-up.
Myelitis occurred as a second relapse for 2 patients and 5 patients experienced a progressive course of the disease. The small size of our cohort is a consequence of the rarity of this clinical manifestation in MS. These atypical myelitis are the first relapse for 12 of 16 patients, it seems to be the starter of the pathology in this form.
A better recovery than in the NMO spectrum disorders or systemic diseases seems to emerge at the beginning of the pathology but also a quicker evolution towards progressive form.
The atypical myelitis are not frequent in MS and seem to be an entity which have a medullary tropism, during the first relapse and the recurrences.
Disclosure: Nothing to disclose
Abstract: EP1303
Type: ePoster
Abstract Category: Clinical aspects of MS - 2 MS Variants
The 'atypical' myelitis of multiple sclerosis (MS), are characterised by longitudinally extensive myelitis (≥3 vertebral segments), transverse myelitis (> 50% of spinal cord in the axial plane), or pseudovascular (anterior or central) cord lesions.
This study is observational, retrospective, multicentric, and includes incident cases between 2012 and 2017. Sixteen patients were included in the University Hospital of Strasbourg, Nice, Poitiers and Montpellier in France.
We collected demographic information, clinical and radiological characteristics of myelitis, laboratory results including CSF, brain and spinal cord MRI, treatment, and clinical follow-up.
The aim of this study was to collect atypical cases of myelitis related to MS to better characterise this population.
All patients fulfilled 2010 Macdonald criteria without any other alternative diagnosis. The mean age of onset was 39,1 +/- 12,4 years, the sex ratio was 1,6 women for 1 man. The myelitis was the first relapse for 12 patients, the second for 2 patients and the third for 1 patient. The intrathecal synthesis of immunoglobulin was found in all cases. On spinal cord MRI, we observed 3 longitudinally extensive myelitis, 9 transverse myelitis, 3 transverse and longitudinally extensive myelitis and 3 patients have an association with a central cord lesion. The median EDSS was 4,75 [1-8] during the relapse, 4,5 [0-6,5] after 6 months and 3,5 [0-7] after 3,9 +/- 3,1 years of follow-up.
Myelitis occurred as a second relapse for 2 patients and 5 patients experienced a progressive course of the disease. The small size of our cohort is a consequence of the rarity of this clinical manifestation in MS. These atypical myelitis are the first relapse for 12 of 16 patients, it seems to be the starter of the pathology in this form.
A better recovery than in the NMO spectrum disorders or systemic diseases seems to emerge at the beginning of the pathology but also a quicker evolution towards progressive form.
The atypical myelitis are not frequent in MS and seem to be an entity which have a medullary tropism, during the first relapse and the recurrences.
Disclosure: Nothing to disclose