Contributions
Abstract: EP1299
Type: ePoster
Abstract Category: Clinical aspects of MS - 2 MS Variants
Background: Tumefactive demyelinating lesion (TDL) is a rare form of demyelinating disorder, which recently has received more attention. TDL is defined as a demyelinating lesion larger than 2 cm. In most cases, although TDL represents a form of multiple sclerosis(MS), according to current knowledge TDL refers a heterogeneous group of inflammatory central nervous system demyelination. The pathogenesis of TDL is unknown. But, recent case reports demonstrated the presence of aquaporin 4(AQP4) IgG in cases with TDLs.
Objective: To reveal if there is any relation between the occurrence of TDL and antibodies against myelin-oligodendrocyte glycoprotein(MOG) and AQP4.
Methods: All patients were seen in Istanbul University Cerrahpasa School of Medicine Neuroimmunology Unit. Twenty-four patients with TDL which larger than 2 cm were included. All serum samples were analyzed at Tohoku University. The cell-based assays (CBA) were used to test AQP4 and MOG antibodies.
Results: Most of the patients were female (17 female). The mean age of the patients was 34.26 (range:16-56). The mean age at the time of first symptom was 27.66 (range: 11-40). No patients were receiving any treatment such as natalizumab or fingolimod during or before the development of TDL. The mean follow-up duration was 46.89 months. During follow-up, patients with TDL either converted to MS or didn't have any further attack. None of them diagnosed as neuromyelitis optica or Balo's concentric sclerosis. All patients with TDL were found to be negative regarding to anti-aquaporin-4 IgG and anti MOG IgG.
Conclusions: Our study did not reveal any relation between TDL and the presence of antibodies against MOG and AQP4.
Disclosure:
Ayse Altintas:nothing to disclose
Toshiyuki Takahashi:nothing to disclose
Aksel Siva:nothing to disclose
Sabahattin Saip:nothing to disclose
Ugur Uygunoglu:nothing to disclose
Cengiz Yalcinkaya:nothing to disclose
Kazuo Fujihara:nothing to disclose
Abstract: EP1299
Type: ePoster
Abstract Category: Clinical aspects of MS - 2 MS Variants
Background: Tumefactive demyelinating lesion (TDL) is a rare form of demyelinating disorder, which recently has received more attention. TDL is defined as a demyelinating lesion larger than 2 cm. In most cases, although TDL represents a form of multiple sclerosis(MS), according to current knowledge TDL refers a heterogeneous group of inflammatory central nervous system demyelination. The pathogenesis of TDL is unknown. But, recent case reports demonstrated the presence of aquaporin 4(AQP4) IgG in cases with TDLs.
Objective: To reveal if there is any relation between the occurrence of TDL and antibodies against myelin-oligodendrocyte glycoprotein(MOG) and AQP4.
Methods: All patients were seen in Istanbul University Cerrahpasa School of Medicine Neuroimmunology Unit. Twenty-four patients with TDL which larger than 2 cm were included. All serum samples were analyzed at Tohoku University. The cell-based assays (CBA) were used to test AQP4 and MOG antibodies.
Results: Most of the patients were female (17 female). The mean age of the patients was 34.26 (range:16-56). The mean age at the time of first symptom was 27.66 (range: 11-40). No patients were receiving any treatment such as natalizumab or fingolimod during or before the development of TDL. The mean follow-up duration was 46.89 months. During follow-up, patients with TDL either converted to MS or didn't have any further attack. None of them diagnosed as neuromyelitis optica or Balo's concentric sclerosis. All patients with TDL were found to be negative regarding to anti-aquaporin-4 IgG and anti MOG IgG.
Conclusions: Our study did not reveal any relation between TDL and the presence of antibodies against MOG and AQP4.
Disclosure:
Ayse Altintas:nothing to disclose
Toshiyuki Takahashi:nothing to disclose
Aksel Siva:nothing to disclose
Sabahattin Saip:nothing to disclose
Ugur Uygunoglu:nothing to disclose
Cengiz Yalcinkaya:nothing to disclose
Kazuo Fujihara:nothing to disclose