Contributions
Abstract: EP1282
Type: ePoster
Abstract Category: Clinical aspects of MS - 1 Diagnosis and differential diagnosis
Aim: The main purpose of this study was to investigate demographic and clinical characteristics of patients with multiple sclerosis (MS) diagnosed according to different criteria between 1986 and 2015.
Material and methods: We analysed medical records of patients with MS diagnosed between 1986 and 2015. The patients were divided into 4 separate subgroups according to following criteria: A) Poser, n=145, B) McDonald 2000, n=66, C) McDonald 2005, n=62, and D) McDonald 2010, n=60. We aimed to investigate: 1) demographic characteristics, including sex and age, 2) the time between first symptoms suggestive of MS and confirmed diagnosis of MS, 3) severity of impairment at diagnosis assessed with the EDSS and symptoms that prompted workup for MS.
Results: We included 333 patients with definite MS. The female-to-male ratio for the whole group was 2.3:1, whereas in subgroups it differed significantly (A - 1.9; B - 1.6; C - 4.6; D - 3.6, A vs D, p=0.001).
The mean age at diagnosis decreased gradually in subsequent groups (A - 39.6±13.3; B - 37.7±12.8; C - 35.4±13.0; D - 29.9±9.3 years, p< 0.001). Moreover, the time from the first symptom suggestive of MS to confirmed diagnosis shortened significantly (A - 88.9 ±80.2; B - 39.1±68.4; C - 36.2 ±58.4; D - 33.5±68.2 months, p< 0.0001). The disability level measured at diagnosis on the EDSS decreased in consecutive subgroups (A - 4.4±2.2; B - 3.1 ±1.7; C - 2.7 ±1.3; D - 2.8±1.4). Pyramidal symptoms remained the most common manifestation of the disease at diagnosis regardless of the diagnostic criteria (A - 50.34%, B - 54.55%, C - 32.26%, D - 31.67). However, an increasing trend for visual dysfunction was observed (A - 15.9%, B - 14%, C - 19%, D - 23.3%; A vs. D, p< 0.0001).
Conclusions: Our study indicates a significant change in demographic and clinical characteristics of patients with MS diagnosed according to the relevant criteria. Over the analysed period, the diagnosis was made at a younger age and more often in women, the time gap between first symptoms suggestive of MS and confirmed diagnosis shortened, and disability at diagnosis decreased.
Disclosure: Nothing to disclose
Abstract: EP1282
Type: ePoster
Abstract Category: Clinical aspects of MS - 1 Diagnosis and differential diagnosis
Aim: The main purpose of this study was to investigate demographic and clinical characteristics of patients with multiple sclerosis (MS) diagnosed according to different criteria between 1986 and 2015.
Material and methods: We analysed medical records of patients with MS diagnosed between 1986 and 2015. The patients were divided into 4 separate subgroups according to following criteria: A) Poser, n=145, B) McDonald 2000, n=66, C) McDonald 2005, n=62, and D) McDonald 2010, n=60. We aimed to investigate: 1) demographic characteristics, including sex and age, 2) the time between first symptoms suggestive of MS and confirmed diagnosis of MS, 3) severity of impairment at diagnosis assessed with the EDSS and symptoms that prompted workup for MS.
Results: We included 333 patients with definite MS. The female-to-male ratio for the whole group was 2.3:1, whereas in subgroups it differed significantly (A - 1.9; B - 1.6; C - 4.6; D - 3.6, A vs D, p=0.001).
The mean age at diagnosis decreased gradually in subsequent groups (A - 39.6±13.3; B - 37.7±12.8; C - 35.4±13.0; D - 29.9±9.3 years, p< 0.001). Moreover, the time from the first symptom suggestive of MS to confirmed diagnosis shortened significantly (A - 88.9 ±80.2; B - 39.1±68.4; C - 36.2 ±58.4; D - 33.5±68.2 months, p< 0.0001). The disability level measured at diagnosis on the EDSS decreased in consecutive subgroups (A - 4.4±2.2; B - 3.1 ±1.7; C - 2.7 ±1.3; D - 2.8±1.4). Pyramidal symptoms remained the most common manifestation of the disease at diagnosis regardless of the diagnostic criteria (A - 50.34%, B - 54.55%, C - 32.26%, D - 31.67). However, an increasing trend for visual dysfunction was observed (A - 15.9%, B - 14%, C - 19%, D - 23.3%; A vs. D, p< 0.0001).
Conclusions: Our study indicates a significant change in demographic and clinical characteristics of patients with MS diagnosed according to the relevant criteria. Over the analysed period, the diagnosis was made at a younger age and more often in women, the time gap between first symptoms suggestive of MS and confirmed diagnosis shortened, and disability at diagnosis decreased.
Disclosure: Nothing to disclose