Contributions
Abstract: EP1278
Type: ePoster
Abstract Category: Clinical aspects of MS - 1 Diagnosis and differential diagnosis
Background: Acute Myelitis (AM) could be infectious/ para-infectious or secondary to conditions like multiple sclerosis (MS), neuromyelitis optica (NMO), systemic lupus erythematous, etc. Besides, AM may be idiopathic where the underlying etiology is undetermined.
Objective: In this multi-centric study from India, we aim to determine
(1) the distribution of AM on the basis of etiology and
(2) rate of conversion of AM to MS.
Method: In the period 2009-2016, consecutive AM cases were recruited from several centers in the city of Kolkata, India. Compressive, toxic, metabolic, vascular, hereditary and paraneoplastic myelopthies were excluded. Following careful history and examination, all had baseline routine blood, anti-nuclear antibody, angiotensin-converting enzyme and serum NMO-IgG (cell-based method). Routine CSF analysis and identification of oligoclonal band by iso-electric focusing method were performed. Cerebrospinal MRI with contrast were carried out in all cases. Idiopathic AM cohorts were followed up with cerebrospinal MRI performed annually or earlier if required.
Results: Out of the total 64 (men 37, women 27) AM cohorts (age range, 18-54 years; mean ± SD, 37.27 ± 9.98 years), there were 12 (18.7%) post-infectious/ infectious and 4 (6.2%) NMO spectrum disorders. In a ≥ 2 year follow up of 24 idiopathic AM cohorts, 8 (33.3%) converted to MS. Six individuals had recurrent AM but they had no evidence of MS or NMO. All who converted to MS had 1 or more cerebral lesions at baseline, whereas none of those who failed to convert had any cerebral lesion.
Conclusion: The conversion rate from idiopathic ON to MS in our study is similar to that in the Western countries. On the other hand, NMO spectrum disorder is more prevalent in our country.
Disclosure:
1. TK Banerjee: The study is funded by Biogen
2. Ghosh E: nothing to disclose
3. Saha M: nothing to disclose
4. Das A: nothing to disclose
5. Chowdhury D: nothing to disclose
6. Ojha S: nothing to disclose
7. Nandi SS:nothing to disclose
8. Halder A: nothing to disclose
9. Ghosh A: nothing to disclose
10. Dutta A: nothing to disclose
11. Purakayastha S: nothing to disclose
Abstract: EP1278
Type: ePoster
Abstract Category: Clinical aspects of MS - 1 Diagnosis and differential diagnosis
Background: Acute Myelitis (AM) could be infectious/ para-infectious or secondary to conditions like multiple sclerosis (MS), neuromyelitis optica (NMO), systemic lupus erythematous, etc. Besides, AM may be idiopathic where the underlying etiology is undetermined.
Objective: In this multi-centric study from India, we aim to determine
(1) the distribution of AM on the basis of etiology and
(2) rate of conversion of AM to MS.
Method: In the period 2009-2016, consecutive AM cases were recruited from several centers in the city of Kolkata, India. Compressive, toxic, metabolic, vascular, hereditary and paraneoplastic myelopthies were excluded. Following careful history and examination, all had baseline routine blood, anti-nuclear antibody, angiotensin-converting enzyme and serum NMO-IgG (cell-based method). Routine CSF analysis and identification of oligoclonal band by iso-electric focusing method were performed. Cerebrospinal MRI with contrast were carried out in all cases. Idiopathic AM cohorts were followed up with cerebrospinal MRI performed annually or earlier if required.
Results: Out of the total 64 (men 37, women 27) AM cohorts (age range, 18-54 years; mean ± SD, 37.27 ± 9.98 years), there were 12 (18.7%) post-infectious/ infectious and 4 (6.2%) NMO spectrum disorders. In a ≥ 2 year follow up of 24 idiopathic AM cohorts, 8 (33.3%) converted to MS. Six individuals had recurrent AM but they had no evidence of MS or NMO. All who converted to MS had 1 or more cerebral lesions at baseline, whereas none of those who failed to convert had any cerebral lesion.
Conclusion: The conversion rate from idiopathic ON to MS in our study is similar to that in the Western countries. On the other hand, NMO spectrum disorder is more prevalent in our country.
Disclosure:
1. TK Banerjee: The study is funded by Biogen
2. Ghosh E: nothing to disclose
3. Saha M: nothing to disclose
4. Das A: nothing to disclose
5. Chowdhury D: nothing to disclose
6. Ojha S: nothing to disclose
7. Nandi SS:nothing to disclose
8. Halder A: nothing to disclose
9. Ghosh A: nothing to disclose
10. Dutta A: nothing to disclose
11. Purakayastha S: nothing to disclose