Contributions
Abstract: EP1275
Type: ePoster
Abstract Category: Clinical aspects of MS - 1 Diagnosis and differential diagnosis
Introduction: The central vein sign (CVS) is a new finding in MS studies, which could help improve MS diagnosis. This sign has yet to be studied on 3D isotropic sequences at different magnetic fields, especially on 1.5T for everyday clinical practice. Our purpose was to evaluate the central vein across 1.5T, 3T, and 7T MRI scanners.
Methods: Three MS patients from the NINDS (National Institute of Neurological Disorders and Stroke) cohort underwent brain imaging on 3 different MRI scanners (1.5T, 3T, and 7T). Three MS plaques detected on the different scans were selected for each patient. Central vein assessment used a whole-brain high-resolution isotropic T2*-weighted sequence acquired in under 6 minutes at the three different field strengths. At 1.5T and 3T, this sequence was acquired during, or shortly after, the injection of gadolinium-based contrast agent (GBCA). Assessment of MS plaques and veins were made using the definitions from the 2016 North American Imaging in MS Cooperative consensus statement.
Results: Eight out of 9 lesions were central vein-positive on the 3 scanners. Four were located in the deep white matter and 5 were periventricular. Only one lesion had a vein that was visible at 3T and 7T but not at 1.5T.
Conclusion: This pilot study indicates that it is possible to detect central veins in MS plaques on 1.5T images with a good reproducibility compared to 3T and 7T images. More MS patients will undergo the same imaging protocol to confirm these initial findings and investigate whether GBCA injection is required at 1.5T and 3T when assessing CVS.
Disclosure:
Alix Fechner: nothing to disclose
Julien Savatovsky: nothing to disclose
Jean-Claude Sadik: nothing to disclose
Daniel S. Reich: nothing to disclose
Pascal Roux: nothing to disclose
Pascal Sati: nothing to disclose
Abstract: EP1275
Type: ePoster
Abstract Category: Clinical aspects of MS - 1 Diagnosis and differential diagnosis
Introduction: The central vein sign (CVS) is a new finding in MS studies, which could help improve MS diagnosis. This sign has yet to be studied on 3D isotropic sequences at different magnetic fields, especially on 1.5T for everyday clinical practice. Our purpose was to evaluate the central vein across 1.5T, 3T, and 7T MRI scanners.
Methods: Three MS patients from the NINDS (National Institute of Neurological Disorders and Stroke) cohort underwent brain imaging on 3 different MRI scanners (1.5T, 3T, and 7T). Three MS plaques detected on the different scans were selected for each patient. Central vein assessment used a whole-brain high-resolution isotropic T2*-weighted sequence acquired in under 6 minutes at the three different field strengths. At 1.5T and 3T, this sequence was acquired during, or shortly after, the injection of gadolinium-based contrast agent (GBCA). Assessment of MS plaques and veins were made using the definitions from the 2016 North American Imaging in MS Cooperative consensus statement.
Results: Eight out of 9 lesions were central vein-positive on the 3 scanners. Four were located in the deep white matter and 5 were periventricular. Only one lesion had a vein that was visible at 3T and 7T but not at 1.5T.
Conclusion: This pilot study indicates that it is possible to detect central veins in MS plaques on 1.5T images with a good reproducibility compared to 3T and 7T images. More MS patients will undergo the same imaging protocol to confirm these initial findings and investigate whether GBCA injection is required at 1.5T and 3T when assessing CVS.
Disclosure:
Alix Fechner: nothing to disclose
Julien Savatovsky: nothing to disclose
Jean-Claude Sadik: nothing to disclose
Daniel S. Reich: nothing to disclose
Pascal Roux: nothing to disclose
Pascal Sati: nothing to disclose