Contributions
Abstract: 200
Type: Oral
Abstract Category: Pathology and pathogenesis of MS - Imaging
Background: The presence of cardiovascular (CV) comorbidities such as arterial hypertension (AHT) or hyperlipidemia (HLP) in multiple sclerosis (MS) patients has been associated with a more severe disease course. Less is known about the impact of those conditions on temporal changes of lesion load and brain volume.
Aim: To explore the influence of comorbidities on changes in brain volume and lesion load in patients with early MS.
Methods: We identified 120 patients with early MS according to the McDonald criteria 2005 (n=63) or a clinically isolated syndrome (CIS) (n=57) suggestive of MS in our MS-database who had a fully documented clinical history including comorbidities, smoking status and repeated 3-Tesla cerebral MRI examinations.
CV comorbidities assessed were AHT, HLP, diabetes mellitus and smoking.
Imaging parameters included T2-lesion load (T2-LL), normalized brain volume (NBV), cortical grey (cGMV) and white matter volume (WMV). The percentage of brain volume change (PBVC) over time was assessed using the semi-automated software SIENA.
Results: The study population consisted of 78 (65%) women and 42 (35%) men; their mean age at baseline was 33.7 (±9.3) years. The mean follow-up (FU) period was 43 (±15) months. 39 patients (32.5%) had one or more CV comorbidities (CV+; absent: CV-) that were independent of age and disease course at baseline. Neither the EDSS at baseline (mean CV+: 1.9 vs CV-: 1.5; p=0.26) nor at last FU (mean CV+: 2.0 vs. CV-: 1.7) significantly differed between patients with and those without CV comorbidities. CV+ patients however had lower NBV and lower cGMV at baseline (1514.6cm3 vs. CV-: 1564.8cm3, p=0.023; 628.7cm3 vs. CV-: 652.8cm3, p=0.019) and at last follow-up (1495.9cm3 vs. CV-: 1541.8cm3, p=0.036; 619.6cm3 vs. CV-: 638.8cm3, p=0.045). Lesion load at baseline (CV+: 6.3cm3 ± 12.03cm3 vs. CV-: 5.9cm3 ± 10.6cm3; p=0.87) and follow-up (CV+: 6.6cm3 ± 12.6cm3 vs CV-: 5.4 cm3 ± 10.2cm3; p=0.49) was similar in both groups. PBVC and the accrual of lesion load were comparable during the observation period between these groups.
Conclusion: CV comorbidities are quite frequent in young adults in early stages of MS and their presence appears to be associated with a lower brain volume. A larger patient number and longer follow-up is needed to address the contribution of individual risk factors and to substantiate longitudinal changes.
Disclosure: nothing to disclose
Abstract: 200
Type: Oral
Abstract Category: Pathology and pathogenesis of MS - Imaging
Background: The presence of cardiovascular (CV) comorbidities such as arterial hypertension (AHT) or hyperlipidemia (HLP) in multiple sclerosis (MS) patients has been associated with a more severe disease course. Less is known about the impact of those conditions on temporal changes of lesion load and brain volume.
Aim: To explore the influence of comorbidities on changes in brain volume and lesion load in patients with early MS.
Methods: We identified 120 patients with early MS according to the McDonald criteria 2005 (n=63) or a clinically isolated syndrome (CIS) (n=57) suggestive of MS in our MS-database who had a fully documented clinical history including comorbidities, smoking status and repeated 3-Tesla cerebral MRI examinations.
CV comorbidities assessed were AHT, HLP, diabetes mellitus and smoking.
Imaging parameters included T2-lesion load (T2-LL), normalized brain volume (NBV), cortical grey (cGMV) and white matter volume (WMV). The percentage of brain volume change (PBVC) over time was assessed using the semi-automated software SIENA.
Results: The study population consisted of 78 (65%) women and 42 (35%) men; their mean age at baseline was 33.7 (±9.3) years. The mean follow-up (FU) period was 43 (±15) months. 39 patients (32.5%) had one or more CV comorbidities (CV+; absent: CV-) that were independent of age and disease course at baseline. Neither the EDSS at baseline (mean CV+: 1.9 vs CV-: 1.5; p=0.26) nor at last FU (mean CV+: 2.0 vs. CV-: 1.7) significantly differed between patients with and those without CV comorbidities. CV+ patients however had lower NBV and lower cGMV at baseline (1514.6cm3 vs. CV-: 1564.8cm3, p=0.023; 628.7cm3 vs. CV-: 652.8cm3, p=0.019) and at last follow-up (1495.9cm3 vs. CV-: 1541.8cm3, p=0.036; 619.6cm3 vs. CV-: 638.8cm3, p=0.045). Lesion load at baseline (CV+: 6.3cm3 ± 12.03cm3 vs. CV-: 5.9cm3 ± 10.6cm3; p=0.87) and follow-up (CV+: 6.6cm3 ± 12.6cm3 vs CV-: 5.4 cm3 ± 10.2cm3; p=0.49) was similar in both groups. PBVC and the accrual of lesion load were comparable during the observation period between these groups.
Conclusion: CV comorbidities are quite frequent in young adults in early stages of MS and their presence appears to be associated with a lower brain volume. A larger patient number and longer follow-up is needed to address the contribution of individual risk factors and to substantiate longitudinal changes.
Disclosure: nothing to disclose