Abstract: 176
Type: Oral
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Background: Progressive Multiple Sclerosis (PrMS) represents a population of high medical and social burden. Cognitive impairment is a relevant contributor, including, among others, memory and processing speed deficits. Social Cognition (SC), the ability to understand the mind of others, has been recently explored in early MS and it directly influences social support and quality of life of patients and families.
Goals: To explore SC by means of the mini-Social Cognition and Emotional Assessment (mini-SEA) in a cohort of PrMS patients and its correlation with brain atrophy, depression, fatigue, quality of life (QOL), physical and cognitive impairment.
Methods: A prospective cohort of PrMS patients was evaluated using Theory of the Mind tasks (mini-SEA): Faux Pas and Face Emotion Recognition. Disability was assessed by a trained neurologist using the Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Functional Composite (MSFC); Cognitive evaluations included memory (visual/verbal), processing speed, working memory, and cognitive shifts; Brain Atrophy measures included Structural Image Evaluation using Normalization of Atrophy (SIENAX-normalized brain volume-NBV; normalized grey matter volume-NGMV; normalized white matter volume-NWMV) and Corpus Callosum Index (CCI) using volumetric T1-weighted images. Depression, fatigue and QOL scales were also performed.
Results: Thirty nine (39) PrMS were recruited (21 primary, 18 secondary progressive), mean age 56.2 years, 24 women, mean disease duration 15.5 years, median EDSS 6.0. Mean mini-SEA Z-score was -1.5 (range -6.3 to 1.8) and was correlated with MSFC (p=0.05), visual memory (p=0.008), cognitive shifts (p< 0.001), posterior CCI (p=0.003) and NGMV (p=0.004). Patients with SC impairment represented the 38.4% of the sample (15/39), and these patients also had lower NGMV (p=0.02), verbal and visual memory scores (p=0.005), and lower MSFC scores (p=0.03) compared to normal mini-SEA score patients. No differences were found in age, gender, primary/secondary progression, disease duration, EDSS, depression, fatigue, QOL, NBV and NWMV, or other cognitive tests between these groups. In this cohort, QOL was mainly influenced by EDSS, fatigue and depression.
Conclusions: In PrMS patients, Social Cognition is associated with selective cognitive impairment and grey matter and posterior corpus callosum atrophy. Its impact on daily activities and social burden may represent a new area to explore in PrMS patients.
Disclosure:
Macarena Vasquez declare no conflict of interest
Ethel Ciampi declare no conflict of interest
Reinaldo Uribe declare no conflict of interest
Tomás Labbe declare no conflict of interest
Diego Reyes declare no conflict of interest
Karolyn Molnar declare no conflict of interest
Juan Pablo Cruz declare no conflict of interest
Patricia Lillo declare no conflict of interest
Andrea Slachevsky declare no conflict of interest
Amparo Ruiz Tagle declare no conflict of interest
Carmen Pinto declare no conflict of interest
Ana Reyes declare no conflict of interest
Elizabeth Vergara declare no conflict of interest
Daniella Weaver declare no conflict of interest
Patricia Feliu declare no conflict of interest
Claudia Carcamo declare no conflict of interest
Abstract: 176
Type: Oral
Abstract Category: Pathology and pathogenesis of MS - Neuropsychology
Background: Progressive Multiple Sclerosis (PrMS) represents a population of high medical and social burden. Cognitive impairment is a relevant contributor, including, among others, memory and processing speed deficits. Social Cognition (SC), the ability to understand the mind of others, has been recently explored in early MS and it directly influences social support and quality of life of patients and families.
Goals: To explore SC by means of the mini-Social Cognition and Emotional Assessment (mini-SEA) in a cohort of PrMS patients and its correlation with brain atrophy, depression, fatigue, quality of life (QOL), physical and cognitive impairment.
Methods: A prospective cohort of PrMS patients was evaluated using Theory of the Mind tasks (mini-SEA): Faux Pas and Face Emotion Recognition. Disability was assessed by a trained neurologist using the Expanded Disability Status Scale (EDSS) and Multiple Sclerosis Functional Composite (MSFC); Cognitive evaluations included memory (visual/verbal), processing speed, working memory, and cognitive shifts; Brain Atrophy measures included Structural Image Evaluation using Normalization of Atrophy (SIENAX-normalized brain volume-NBV; normalized grey matter volume-NGMV; normalized white matter volume-NWMV) and Corpus Callosum Index (CCI) using volumetric T1-weighted images. Depression, fatigue and QOL scales were also performed.
Results: Thirty nine (39) PrMS were recruited (21 primary, 18 secondary progressive), mean age 56.2 years, 24 women, mean disease duration 15.5 years, median EDSS 6.0. Mean mini-SEA Z-score was -1.5 (range -6.3 to 1.8) and was correlated with MSFC (p=0.05), visual memory (p=0.008), cognitive shifts (p< 0.001), posterior CCI (p=0.003) and NGMV (p=0.004). Patients with SC impairment represented the 38.4% of the sample (15/39), and these patients also had lower NGMV (p=0.02), verbal and visual memory scores (p=0.005), and lower MSFC scores (p=0.03) compared to normal mini-SEA score patients. No differences were found in age, gender, primary/secondary progression, disease duration, EDSS, depression, fatigue, QOL, NBV and NWMV, or other cognitive tests between these groups. In this cohort, QOL was mainly influenced by EDSS, fatigue and depression.
Conclusions: In PrMS patients, Social Cognition is associated with selective cognitive impairment and grey matter and posterior corpus callosum atrophy. Its impact on daily activities and social burden may represent a new area to explore in PrMS patients.
Disclosure:
Macarena Vasquez declare no conflict of interest
Ethel Ciampi declare no conflict of interest
Reinaldo Uribe declare no conflict of interest
Tomás Labbe declare no conflict of interest
Diego Reyes declare no conflict of interest
Karolyn Molnar declare no conflict of interest
Juan Pablo Cruz declare no conflict of interest
Patricia Lillo declare no conflict of interest
Andrea Slachevsky declare no conflict of interest
Amparo Ruiz Tagle declare no conflict of interest
Carmen Pinto declare no conflict of interest
Ana Reyes declare no conflict of interest
Elizabeth Vergara declare no conflict of interest
Daniella Weaver declare no conflict of interest
Patricia Feliu declare no conflict of interest
Claudia Carcamo declare no conflict of interest